期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 -, 页码 138-142出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.10.034
关键词
Guanidinobenzimidazole; Dihydroimidazole; [1,3,5]Triazins; Halogenated active methylenes; Anti-bacterial
Reaction of 2-guanidinobenzimidazole with halogenated active methylenes and ketones gave dihydroimidazole and 3,4-dihydrobenzo[4,5]imidazo [1,2-a][1,3,5]triazin derivatives in very good yield. The anti-bacterial evaluation of the newly synthesized products against broad spectrum of bacteria was performed. Most of products showed high inhibitory effect. All compounds have been characterized based on IR, H-1 NMR. C-13 NMR and Mass spectra. (C) 2011 Elsevier Masson SAS. All rights reserved.
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