期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 -, 页码 370-376出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.11.005
关键词
Benzofurocoumarins; Benzopsoralen analogues; Antitumor activity; Docking; Computational studies
资金
- FCT
- FEDER, National NMR Network [REEQ/630/QUI/2005, SFRH/BD/48636/2008]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/48636/2008] Funding Source: FCT
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship. (C) 2011 Elsevier Masson SAS. All rights reserved.
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