期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 5, 页码 1483-1498出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.01.042
关键词
GABA-uptake inhibitor; mGAT3; Imidazole; Antiepileptic
A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the four GABA uptake transporters mGAT1-4 stably expressed in HEK cells. Further two bicyclic compounds with a rigidified carboxylic acid side chain were included in this study. The results of the biological tests indicated that most omega-imidazole alkanoic and alkenoic acid derivatives exhibit the highest potencies as GABA uptake inhibitors at mGAT3. (C) 2011 Elsevier Masson SAS. All rights reserved.
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