期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 1, 页码 150-159出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.10.030
关键词
Thiosemicarbazone; Thiazoline; Crystal structure; Metal complexes; Antibacterial activity
资金
- Universidad de Extremadura
The new ligand 2-acetyl-2-thiazoline thiosemicarbazone (HATtsc) and the complexes [Co(ATtsc)(2)](2)[CoCl4]center dot 2H(2)O (1), [Co(ATtsc)(2)]NO3 center dot H2O (2), [Ni(HATtsc)(2)](NO3)(2) (3), [ZnCl2(HATtsc)]center dot CH3CN (4), [{CdCl(HATtsc)}(2)(mu-Cl)(2)]center dot 2H(2)O (5) and [{Cd(NO3)(HATtsc)}(2)(mu-NO3)(2)] (6) were isolated and characterized by a variety of physico-chemical techniques and X-ray diffraction. The structure of HATtsc in 1 and 2 presented a thiolate form while in 3-6 the thione form was present, as it was in free ligand. In addition, we studied the antibacterial activity of the ligand and complexes 2-6 against some representative bacteria. Cd(II) complexes were more active against Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Bacillus subtilis than organic ligand. Conversely, Cd(II) compounds seemed to interfere in the cell separation of B. subtilis. (C) 2010 Elsevier Masson SAS. All rights reserved.
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