期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 1, 页码 364-369出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2010.10.022
关键词
Indole[1,2-c]-1,2,4-benzotriazine; Cyclization; Sandmeyer reaction; Antifungal activity; Phytopathogenic fungi
资金
- National Natural Science Foundation of China [31071737]
- Program for New Century Excellent University Talents, State Education Ministry of China [NCET-06-0868]
- Fok Ying Tong Education Foundation for Young Talents [121032]
- State Key Laboratory of Applied Organic Chemistry, Lanzhou University
A series of novel indole[1,2-c]-1,2,4-benzotriazine derivatives were obtained by a modified Sandmeyer reaction in the presence of tert-butylnitrite (t-BuONO). As compared with hymexazol, a commercially available agricultural fungicide, at the concentration of 50 mu g/mL, two indole[,2-c]-1,2,4-benzotriazines, 5h and 5k, exhibited the more promising and pronounced antifungal activities in vitro against five phytopathogenic fungi. It clearly demonstrated that introduction of appropriate substituents on the indolyl ring of indole[1,2-c]-1,2,4-benzotriazine (5a) would lead to the more potent derivatives. (C) 2010 Elsevier Masson SAS. All rights reserved.
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