期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 6, 页码 2132-2140出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.066
关键词
Indolizines; Pyrrolo quinolines/isoquinolines; Amberlite-IRA-402 (OH); Dipolar cycloaddition; Antibacterial; Antifungal
资金
- Council of Scientific and Industrial Research, Government of India
A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived from the reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberlite IRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy. (C) 2011 Elsevier Masson SAS. All rights reserved.
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