期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 46, 期 6, 页码 1997-2002出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.022
关键词
Panaxadiol; Anti-tumor; MTT
A series of panaxadiol derivatives have been synthesized by the simple acylation of the 3-hydroxy group of panaxadiol. The anti-tumor activities of the synthesized compounds were evaluated against a panel of human tumor cell lines by the standard MTT assay. Compounds 2,11, 12, 13, 14, 15 and 16 showed stronger antiproliferative activities than that of Rg3 and PD on the growth of the distinct cancer cell lines in vitro. (C) 2011 Elsevier Masson SAS. All rights reserved.
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