期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 4, 页码 1267-1277出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2009.10.028
关键词
1(2H)-Oxo-phthalazine; 1,3,4-Triazole; 1,3,4-Oxadiazole; 1,34-Thiadiazol; Pyrazole; Anti-inflammatory
Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR. (1)H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin (R). (C) 2009 Elsevier Masson SAS. All rights reserved.
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