Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing alpha-aminopyrazines with alpha-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity. (C) 2010 Elsevier Masson SAS. All rights reserved.