Article
Oncology
Guoying Wang, Richard Xu, Boyang Zhang, Xiumei Hong, Tami R. Bartell, Colleen Pearson, Liming Liang, Xiaobin Wang
Summary: This study aimed to investigate whether in utero exposure to diabetes was associated with a change in newborn DNA methylation, and whether the identified CpG sites mediate the association between diabetes and preterm birth. The results showed that newborns born to mothers with diabetes during pregnancy had different DNA methylation patterns compared to newborns of healthy mothers. Additionally, the differentially methylated CpG sites were found to mediate the link between diabetes during pregnancy and preterm birth.
CLINICAL EPIGENETICS
(2023)
Article
Medicine, General & Internal
Zhanqing Zhang, Wei Lu, Dong Zeng, Dan Huang, Weijia Lin, Li Yan, Yanling Feng
Summary: Quantitative HBsAg is more valuable than HBV DNA in predicting significant hepatitis activity of HBeAg-positive chronic HBV infection, with higher sensitivity and specificity levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yu Xiang, Yang Yang, Pu Chen, Xiaofei Lai, Shan Shi, Shuang Li, Wenxian You
Summary: This study examined levels of hepatitis B virus pgRNA in HBsAg and HBsAb copositive patients and found a positive correlation with HBV DNA, HBsAg, ALT, and AST levels. The study also demonstrated significant differences in HBV RNA, HBV DNA, HBsAg, ALT, and AST levels in different natural phases of HBV infection, and suggested that HBV RNA could be used as a virological indicator for antiviral therapy in HBsAg and HBsAb copositive hepatitis B patients.
Article
Chemistry, Analytical
Anna Imbriano, Angelo Tricase, Eleonora Macchia, Luisa Torsi, Paolo Bollella
Summary: This study demonstrates a novel sensing strategy based on double sensing/actuating pathway for the sensitive and selective detection of hepatitis B virus DNA (HBV-DNA). An enzymatic machinery logically operated using physiologically relevant biomarkers is used to trigger the DNA-based AND gate. The proposed biosensor can discriminate between the absence and presence of HBV-DNA with a threshold of 0.05 fM in model buffer solutions and 1 fM in human serum.
ANALYTICA CHIMICA ACTA
(2023)
Article
Pediatrics
Raimund Pechlaner, Anna Posod, Xiaoke Yin, Sean Anthony Burnap, Sophia Julia Kiechl, Manuel Mayr, Stefan Kiechl, Ursula Kiechl-Kohlendorfer
Summary: The study found that very preterm-born preschoolers have reduced levels of platelet activation markers, potentially persisting up to preschool age. Further research is needed to explore the clinical implications of these findings.
PEDIATRIC RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biotechnology & Applied Microbiology
Young-Ah You, Eun Jin Kwon, Han-Sung Hwang, Suk-Joo Choi, Sae Kyung Choi, Young Ju Kim
Summary: Results indicate that elevated methylation of the VTRNA2-1 promoter may lead to an increased risk of preterm birth, possibly caused by pro-inflammatory cytokines. Further studies are needed to confirm this association in a large population and to explore the underlying mechanism.
Review
Gastroenterology & Hepatology
Shiou-Hwei Yeh, Chiao-Ling Li, You-Yu Lin, Ming-Chih Ho, Ya-Chun Wang, Sheng-Tai Tseng, Pei-Jer Chen
Summary: Mechanistic studies of HBV integration-induced insertional mutagenesis have revealed the importance of monitoring residual HCC after therapy or the development of de novo recurrence. HBV integration provides valuable biomarkers for HCC diagnosis and treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Karen K. Kyuregyan, Vera S. Kichatova, Olga Isaeva, Ilya A. Potemkin, Elena Yu Malinnikova, Maria A. Lopatukhina, Anastasia A. Karlsen, Fedor A. Asadi Mobarhan, Eugeniy Mullin, Olga S. Slukinova, Margarita E. Ignateva, Snezhana S. Sleptsova, Elena E. Oglezneva, Elena Shibrik, Maria G. Isaguliants, Mikhail Mikhailov
Summary: The universal hepatitis B vaccination policy in Russia since 1998 has successfully reduced the incidence of acute hepatitis B. However, there are significant differences in vaccination coverage between regions, with parental refusal being a major reason for non-vaccination. Despite high HepB3 coverage by age one, there are still concerns about vaccine safety and necessity among both medical and non-medical students.
Article
Nutrition & Dietetics
Denise L. Jacobson, Daniela Neri, Audrey Gaskins, Lynn Yee, Armando J. Mendez, Kristy Hendricks, Suzanne Siminski, Rebecca Zash, Laurie Hyzy, Jennifer Jao
Summary: Women living with HIV have a higher prevalence of anemia during the third trimester of pregnancy, with anemia being associated with a higher risk of preterm births. These findings emphasize the importance of addressing underlying factors and clinical outcomes of anemia in this population.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Environmental Sciences
Elena Isaevska, Valentina Fiano, Federica Asta, Massimo Stafoggia, Giovenale Moirano, Maja Popovic, Costanza Pizzi, Morena Trevisan, Laura De Marco, Silvia Polidoro, Luigi Gagliardi, Franca Rusconi, Sonia Brescianini, Lorenza Nistico, Maria Antonietta Stazi, Luca Ronfani, Daniela Porta, Lorenzo Richiardi
Summary: Exposure to PM10 pollution during pregnancy can cause changes in cord blood DNA methylation. Exposure during early gestation is associated with more DNA methylation alterations. The study also demonstrates associations between exposure during different gestational periods and newborn telomere length.
ENVIRONMENTAL RESEARCH
(2022)
Article
Immunology
Debika Bhattacharya, Rong Guo, Chi-Hong Tseng, Lynda Emel, Ren Sun, Shih-Hsin Chiu, Lynda Stranix-Chibanda, Tsungai Chipato, Neaka Z. Mohtashemi, Kenneth Kintu, Karim P. Manji, Dhayendre Moodley, Chloe L. Thio, Yvonne Maldonado, Judith S. Currier
Summary: Limited information is available on perinatal outcomes of HIV-hepatitis B virus (HBV) coinfection. Women coinfected with HIV and HBV, especially with high HBV viral loads, are at increased risk of low birth weight and potentially HIV perinatal transmission.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Environmental Sciences
Yoshinori Okamoto, Miyuki Iwai-Shimada, Kunihiko Nakai, Nozomi Tatsuta, Yoko Mori, Akira Aoki, Nakao Kojima, Tatsuyuki Takada, Hiroshi Satoh, Hideto Jinno
Summary: This study aimed to evaluate the effects of five toxic metals and polychlorinated biphenyls (PCBs) on DNA methylation in umbilical cord blood. The results showed that levels of lead (Pb) and antimony (Sb) were positively correlated with DNA methylation content. This suggests that global DNA methylation may be a promising biomarker for prenatal exposure to Pb and Sb.
Article
Nutrition & Dietetics
Zhengyuan Wang, Shenglu Zhao, Xueying Cui, Qi Song, Zehuan Shi, Jin Su, Jiajie Zang
Summary: This study aimed to analyze dietary patterns during pregnancy in Shanghai and their impact on preterm birth. It found that the Animal Food Pattern was significantly associated with preterm birth risk, with higher scores indicating a higher risk.
Article
Biotechnology & Applied Microbiology
Wei Qin, Yao Wang, Xiaqing Zhang, Fan Pan, Kai Cheng, Haitian Sui, Shaoyu Xie
Summary: This study reviewed data from 24 hospitals in Lu'an, Anhui province, China, from 2016 to 2021, and found a high prevalence of preterm birth, low birth weight, and hepatitis B virus infection. The coverage of HepB vaccine and HBIG was high, but the timely vaccination rate of the HepB birth dose was low, and the recommended 4-dose HepB schedule was not fully implemented.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Obstetrics & Gynecology
Alexandros Rodolakis, Nikolaos Thomakos, Nikolaos Akrivos, Maria Sotiropoulou, Ioannis Ioannidis, Dimitrios Haidopoulos, George Vlachos, Aris Antsaklis
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2012)
Review
Obstetrics & Gynecology
Vasileios Pergialiotis, Dimitrios Vlachos, Alexandros Rodolakis, Dimitrios Haidopoulos, Dimitrios Christakis, Georgios Vlachos
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2014)
Article
Obstetrics & Gynecology
Nikolaos Thomakos, Dimitrios Zacharakis, Alexandros Rodolakis, Flora Zagouri, Christos A. Papadimitriou, Aristotle Bamias, Meletios-Athanassios Dimopoulos, Dimitrios Haidopoulos, Georgios Vlahos, Aris Antsaklis
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2014)
Article
Oncology
N. G. Gavalas, M. Tsiatas, O. Tsitsilonis, E. Politi, K. Ioannou, A. C. Ziogas, A. Rodolakis, G. Vlahos, N. Thomakos, D. Haidopoulos, E. Terpos, A. Antsaklis, M. A. Dimopoulos, A. Bamias
BRITISH JOURNAL OF CANCER
(2012)
Letter
Medical Laboratory Technology
Kleopatra H. Schulpis, George D. Vlachos, Aris Antsaklis, Charis Liapi, Vasileios Stolakis, Apostolos Zarros, Stylianos Tsakiris
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2011)
Article
Oncology
A. Bamias, M. Sotiropoulou, F. Zagouri, P. Trachana, K. Sakellariou, E. Kostouros, K. Kakoyianni, A. Rodolakis, G. Vlahos, D. Haidopoulos, N. Thomakos, A. Antsaklis, M. A. Dimopoulos
EUROPEAN JOURNAL OF CANCER
(2012)
Review
Obstetrics & Gynecology
Vasileios Pergialiotis, Dimitrios G. Vlachos, Alexandros Rodolakis, Dimitrios Haidopoulos, Nikolaos Thomakos, Georgios D. Vlachos
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2014)
Article
Oncology
Apostolos C. Ziogas, Nikos G. Gavalas, Marinos Tsiatas, Ourania Tsitsilonis, Ekaterini Politi, Evangelos Terpos, Alexandros Rodolakis, George Vlahos, Nikolaos Thomakos, Dimitrios Haidopoulos, Aristidis Antsaklis, Meletios A. Dimopoulos, Aristotle Bamias
INTERNATIONAL JOURNAL OF CANCER
(2012)
Review
Obstetrics & Gynecology
Vasileios Pergialiotis, Dimitrios Vlachos, Athanasios Protopapas, Kaliopi Pappa, Georgios Vlachos
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2014)
Article
Virology
Ioannis S. Elefsiniotis, Miltos Papadakis, George Vlachos, Elena Vezali, Konstantinos Tsoumakas, George Saroglou, Aristidis Antsaklis
Article
Obstetrics & Gynecology
Kalliopi I. Pappa, Maria Roubelakis, George Vlachos, Spyros Marinopoulos, Antonia Zissou, Nicholas P. Anagnou, Aris Antsaklis
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2011)
Review
Obstetrics & Gynecology
Vassileios Pergialiotis, Alexandros Rodolakis, Dimitrios Christakis, Nikolaos Thomakos, Georgios Vlachos, Aristides Antsaklis
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2013)
Article
Oncology
Aristotle Bamias, Christina Bamia, Alexandra Karadimou, Nikolaos Soupos, Flora Zagouri, Alexandros Rodolakis, Dimitrios Haidopoulos, George Vlahos, Nikos Thomakos, Aristidis Antsaklis, Meletios A. Dimopoulos
Article
Oncology
Aristotle Bamias, Christine Bamia, Flora Zagouri, Efthimios Kostouros, Konstantina Kakoyianni, Alexandros Rodolakis, George Vlahos, Dimitrios Haidopoulos, Nikolaos Thomakos, Aris Antsaklis, Meletios-Athanasios Dimopoulos
Review
Obstetrics & Gynecology
Georgios Vlachos, Athanasios V. Mousiolis, Athanasios Protopapas, Aris Antsaklis
JOURNAL OF GYNECOLOGIC SURGERY
(2012)