Article
Biochemistry & Molecular Biology
Kaushik Chakravarty, Victor G. Antontsev, Maksim Khotimchenko, Nilesh Gupta, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Neha Maharao, Jyotika Varshney
Summary: The COVID-19 pandemic has affected over 100 million people worldwide, prompting the need for accelerated development of anti-viral drugs. Studies have shown that a combination of ACE inhibitors and CCBs may have therapeutic relevance in COVID-19.
Review
Biochemistry & Molecular Biology
Christine Shing Wei Law, Keng Yoon Yeong
Summary: This literature review discusses the potential of repurposing antihypertensives to treat Alzheimer's disease. The relationship between mid-life hypertension and AD has been established, leading to the hypothesis that antihypertensives could be beneficial in managing the disease. Four classes of antihypertensives, along with their potential limitations and prospects in serving as AD therapeutics, are explored in the review.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Tianyi Huang, Mary K. Townsend, Robert L. Dood, Anil K. Sood, Shelley S. Tworoger
Summary: The study did not find clear relationships between the use of antihypertensive medications and ovarian cancer mortality. However, pre-diagnostic use of calcium channel blockers and post-diagnostic use of ACE inhibitors may affect survival rates.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Clinical Neurology
Jonne Lintunen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: This study found that the use of calcium-channel blockers and adenosine modulators is associated with a decreased risk of hospitalization in patients with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Cassia Emanuella Nobrega Malta, Joyce Ohana de Lima Martins, Anna Clara Aragao Matos Carlos, Milena Oliveira Freitas, Iana Aragao Magalhaes, Herica Cristina Alves de Vasconcelos, Isabelly Joyce De Lima Silva-Fernandes, Paulo Goberlanio de Barros Silva
Summary: This study found that factors such as chemotherapy cycles, sex, location of primary tumor, and specific chemotherapy drugs increase the risk of dysgeusia after chemotherapy treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Peripheral Vascular Disease
Yiyun Hu, Ling Liang, Shuang Liu, Janice Y. Kung, Hoan Linh Banh
Summary: Studies have found that angiotensin converting enzyme inhibitors (ACEIs) are more effective than angiotensin receptor blockers (ARBs) in preventing cardiac mortality and morbidity. However, ACEI can cause dry cough as a side effect. This systematic review and network meta-analysis aimed to rank the risk of cough induced by different ACEIs and compared it with placebo, ARB or calcium channel blockers (CCB). The analysis of 135 randomized controlled trials revealed that ACEI had a higher risk of cough compared to ARB and CCB. Moexipril was found to have the highest risk while spirapril had the lowest risk of inducing cough. It is recommended to avoid ACEI in patients at risk of developing cough and consider alternative medications based on the patient's comorbidity.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Nutrition & Dietetics
Bricia Lopez-Plaza, Angel Gil, Adrian Menendez-Rey, Loan Bensadon-Naeder, Thomas Hummel, Jaime Feliu-Batlle, Samara Palma-Milla
Summary: Taste disorders are prevalent among cancer patients undergoing chemotherapy and can lead to reduced food consumption and malnutrition. The consumption of a food supplement containing miraculin from the miracle berry is expected to improve taste perception and nutritional status in malnourished cancer patients. A clinical trial protocol has been designed to evaluate the effects of the supplement on various parameters and determine the optimal dosage.
Article
Neurosciences
Michal Wronski, Jerzy Samochowiec, Justyna Pelka-Wysiecka, Pawel Liskiewicz, Przemyslaw Bienkowski, Blazej Misiak
Summary: This study found a possible relationship between deficit symptoms of schizophrenia and taste disturbances caused by monosodium glutamate (MSG). The intensity of taste perception was negatively correlated with the number of deficit symptoms. Clinicians should monitor and differentiate between actual taste perception deficits and taste hallucinations as symptoms of psychosis.
Article
Peripheral Vascular Disease
Marc D. Basson, William E. Newman, Marilyn G. Klug
Summary: The study found that the possible deleterious effects of thiazides should be considered within the context of the study population, while CCBs may ameliorate BPV over time, but this study does not support choosing CCB over other agents specifically to lessen BPV-associated risk.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Article
Oncology
Ken Ito, Satoshi Yuki, Hiroshi Nakatsumi, Yasuyuki Kawamoto, Kazuaki Harada, Shintaro Nakano, Rika Saito, Takayuki Ando, Kentaro Sawada, Masataka Yagisawa, Atsushi Ishiguro, Masayoshi Dazai, Ichiro Iwanaga, Kazuteru Hatanaka, Atsushi Sato, Ryusuke Matsumoto, Yoshiaki Shindo, Miki Tateyama, Tetsuhito Muranaka, Masaki Katagiri, Isao Yokota, Yuh Sakata, Naoya Sakamoto, Yoshito Komatsu
Summary: This study found that treatment with polaprezinc during chemotherapy can effectively improve dysgeusia in patients with gastrointestinal cancer. There was no significant correlation between the degree of serum zinc elevation and improvement in dysgeusia.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Pharmacology & Pharmacy
Liqiong Ding, Ping Jiang, Xinfeng Xu, Wanzhen Lu, Chan Yang, Lin Li, Pingzheng Zhou, Shuwen Liu
Summary: The study identified T-type calcium channel blockers as potential inhibitors of HSV-2 infection, while L-type calcium channel blockers showed no significant effect. Additionally, benidipine exerted antiviral effects by suppressing viral gene expression in the late stage of infection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Laura Semenzato, Jeremie Botton, Jerome Drouin, Berangere Baricault, Clementine Vabre, Francois Cuenot, Laetitia Penso, Philippe Herlemont, Emilie Sbidian, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik
Summary: Recent evidence suggests that hypertensive patients treated with ACE inhibitors or ARBs may have a lower risk of COVID-19 hospitalization and intubation/death compared to those treated with CCBs. This contradicts initial hypotheses regarding the association between renin-angiotensin-aldosterone system inhibitors and COVID-19 risk, raising new questions for further research.
Article
Dermatology
Laurent Azoulay, Audray St-Jean, Matthew Dahl, Jacqueline Quail, Wusiman Aibibula, James M. Brophy, An-Wen Chan, Lauren Bresee, Greg Carney, Sherif Eltonsy, Hala Tamim, J. Michael Paterson, Robert W. Platt
Summary: A study using Canadian databases found that long-term use and high cumulative doses of HCTZ are associated with an increased risk of keratinocyte carcinoma and melanoma, while there is no association with other medications such as angiotensin-converting enzyme inhibitors and calcium channel blockers.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Francesca Caspani, Antonino Carmelo Tralongo, Leonardo Campiotti, Riccardo Asteggiano, Luigina Guasti, Alessandro Squizzato
Summary: Cardioprotective drugs show a positive effect in preventing anthracycline-induced cardiac damage, with RAAS blockers, beta-blockers, and aldosterone antagonists demonstrating significant benefits in preventing left ventricular ejection fraction reduction based on echocardiographic parameters.
INTERNAL AND EMERGENCY MEDICINE
(2021)
