Review
Biochemistry & Molecular Biology
Lino Hernandez, Mary Lorena Araujo, Waleska Madden, Edgar Del Carpio, Vito Lubes, Giuseppe Lubes
Summary: This review focuses on the interaction between the essential element vanadium and 1,10-phenanthroline and polypyridyl ligands. It summarizes prior work on speciation studies for the vanadium-phenanthroline binary systems and hydrolytic studies of the metal ion. It also provides a comprehensive overview of different X-ray structures known to date and discusses the potential cytotoxic activity of vanadium-polypyridyl complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Hadi Amiri Rudbari, Arezoo Saadati, Mahnaz Aryaeifar, Isabel Correia, Fernanda Marques, Olivier Blacque, Nicola Micale
Summary: A series of oxidovanadium(IV) complexes were synthesized and characterized, showing good anticancer activity in ovarian and breast cancer cells. The newly synthesized V(IV)O complexes exhibited the highest cytotoxicity among all tested compounds.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Maynak Pal, Vanitha Ramu, Dulal Musib, Amit Kunwar, Arunima Biswas, Mithun Roy
Summary: Iron(III)-phenolate/carboxylate complexes have potential for photo-activated chemotherapy. A new red light-absorbing iron(III)-phenolate/carboxylate complex-functionalized gold nanocomposite showed remarkable photocytotoxicity in adenocarcinomic human immortalized keratinocytes and alveolar basal epithelial cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Annie B. McCullough, Jiaqi Chen, Nathaniel P. Valentine, Toney M. Franklin, Andrew P. Cantrell, Vayda M. Darnell, Qasim Qureshi, Kenneth Hanson, Steven M. Shell, Dennis L. Ashford
Summary: This study systematically analyzed the electrochemical, spectrochemical, and photophysical properties of a series of ruthenium polypyridyl complexes. The results showed that modifying the ligands can shift the absorption and emission energies, and revealed the interplay between red-shifting MLCT absorptions and accessing the dissociative (3)dd* states. This work provides important insights for the future design of ligands and complexes for photochemotherapies.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Kane T. McQuaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, James P. Hall, Naoki Sugimoto, Christine J. Cardin
Summary: The DNA G-quadruplex is a DNA structure with various topologies that forms transiently in live cells. This study demonstrates the enantiospecific binding of a ruthenium complex to G-quadruplex and highlights the importance of stabilizing a specific topology for therapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Wenyu Wu Klingler, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane Konig, Patrick Spielmann, Roland H. Wenger, Stefano Ferrari, Bernhard Spingler
Summary: This study reports the design of short PEG chain functionalized Pc photosensitizers to decrease aggregation and increase aqueous solubility. The best-performing photosensitizer, MLC31, showed high photocytotoxicity and mitochondrial targeting under near-infrared light, making it a potential candidate for cisplatin-resistant cancer cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
S. Gutorova, P. Matveev, P. S. Lemport, A. L. Trigub, A. S. Pozdeev, A. Yatsenko, B. N. Tarasevich, E. A. Konopkina, E. K. Khult, V. A. Roznyatovsky, Yu Nelyubina, K. L. Isakovskaya, V. N. Khrustalev, V. S. Petrov, A. S. Aldoshin, Yu A. Ustynyuk, V. G. Petrov, S. N. Kalmykov, V. G. Nenajdenko
Summary: Reprocessing of spent nuclear fuel is crucial for ecology and resource utilization. New extractants are being investigated to minimize solid radioactive waste generation. Promising ligands have been identified for strong complexation with f-elements and effective extraction capabilities.
INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Elizabeth T. Papish, Olaitan E. Oladipupo
Summary: This review discusses light-activated ruthenium anticancer compounds and the factors that influence the preferred pathway. Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) are two main light-activated treatment methods, which depend on the electronic properties of ligands and the characteristics of metal complexes.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shuhua Zhang
Summary: We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes. It was found that these complexes exhibited higher anticancer activity and lower cytotoxicity towards normal cells compared to other substances. Specifically, Cugdupt1 and Cugdupt8 induced cell death through ATP depletion and activation of mitophagy pathways.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Irina V. Krylova, Liliya D. Labutskaya, Mariya O. Markova, Victoriya A. Balycheva, Pavel G. Shangin, Anna Ya. Akyeva, Victoriya V. Golovina, Mikhail E. Minyaev, Andrey V. Lalov, Valery M. Pechennikov, Vasiliy T. Novikov, Mikhail P. Egorov, Mikhail A. Syroeshkin
Summary: Tin coordination derivatives have notable advantages in terms of availability, safety, and stability, making them promising for applications in medicine and materials science. The location and gap between frontier molecular orbitals are crucial factors in determining their properties. In this study, new penta-, hexa-, and hepta-coordinated tin(iv) derivatives were synthesized and characterized. The influence of hypercoordination and bond formation with N-donor ligands on the control and tuning of HOMO and LUMO levels was demonstrated through spectroscopic and electrochemical analyses.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Eli Skelton, Uriel Erasquin, Abhijit Sukul, Aoife Zuercher, Jessica White, Benjamin J. Bythell, Katherine Leslee Asetre Cimatu
Summary: Most photodynamic therapeutics (PDTs) used in cancer treatment require oxygen to efficiently terminate cancer cells, but they are not effective in hypoxic conditions. Rh(III) polypyridyl complexes have been found to have photodynamic therapeutic effect in hypoxic conditions when exposed to UV light. This study proposes the coordination of a BODIPY fluorophore to a rhodium metal center to enhance the reactivity of rhodium under visible light.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kalai Selvan Karumban, Rajnikant Raut, Parth Gupta, Arabinda Muley, Bishnubasu Giri, Sadananda Kumbhakar, Ashish Misra, Somnath Maji
Summary: Mononuclear cobalt(II) complexes were synthesized and characterized, showing strong DNA binding ability and efficient DNA cleavage. These complexes also induced apoptosis in human cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Magdalena Barwiolek, Dominika Jankowska, Mateusz Chorobinski, Anna Kaczmarek-Kedziera, Iwona Lakomska, Slawomir Wojtulewski, Tadeusz M. Muziol
Summary: Two Zn(ii) complexes were successfully synthesized through template reactions and characterized by various methods. The complexes exhibited significant differences in structure and fluorescence properties, with different quantum yields in different solvents. Additionally, DFT calculations were performed to explain the structural and electronic spectral properties of the complexes.
Article
Chemistry, Multidisciplinary
Salvador Celedon, Paul Hamon, Vania Artigas, Mauricio Fuentealba, Samia Kahlal, David Carrillo, Jean-Yves Saillard, Jean-Rene Hamon, Carolina Manzur
Summary: In this contribution, the synthesis, characterization, and electrochemical behavior of a series of chiral ferrocene-functionalized Schiff base compounds were described. The molecular structures and electronic features of these compounds were investigated through experimental and theoretical analyses. This study provides important insights for the synthesis and properties of chiral compounds.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sebastiano Masuri, Maria Grazia Cabiddu, Lukas Moran, Tereza Vessela, Martin Bartosik, Josef Havel, Francesca Meloni, Enzo Cadoni, Petr Vanhara, Tiziana Pivetta
Summary: We synthesized six complexes [Cu(phen)(2)(Lx)](ClO4)(x: 1-6), in which the auxiliary ligand Lx is a coumarin carboxylate derivative with an oxylacetate moiety at the 6th or 7th position and different substituents at the 3rd or 4th position. The complexes exhibit a pentacoordinated geometry around the metal ion. They show affinity towards DNA mainly through electrostatic interactions and groove binding, and the interactions with DNA base pairs are mediated by the auxiliary ligands. The Cu(II) complexes display cytotoxic activity in the micromolar concentration range and can induce the pro-apoptotic branch of the unfolded protein response (UPR) by interfering at the endoplasmic reticulum level. The actin-normalized CHOP to BiP density ratios suggest that the novel compounds preferentially induce the pro-apoptotic UPR signaling driven by CHOP, in a dose-dependent manner and depending on the substituents in the coumarin moiety.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Ai Ouyang, Jiaqi He, Juan Xie, Samya Banerjee, Qianling Zhang, Pingyu Zhang
Summary: A novel cyanine-rhenium(i) tricarbonyl complex has been developed as a potent sonosensitizer and sono-activatable CO-releasing agent for synergistic sonodynamic therapy and CO gas therapy of cancer. The complex induced ferroptosis as the mode of cell death.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhongxian Fan, Jiaen Xie, Tumpa Sadhukhan, Chao Liang, Can Huang, Wenqing Li, Tingxuan Li, Pingyu Zhang, Samya Banerjee, Krishnan Raghavachari, Huaiyi Huang
Summary: Four photo-catalysts were synthesized and characterized, showing strong visible light absorption and efficient photo-catalytic oxidation of cellular coenzymes. Among them, Ir2 exhibited superior anti-cancer activity against HeLa cells compared to a clinically used photosensitizer, and demonstrated in vivo photo-induced catalytic anticancer activity in mouse models.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Medicinal
Ashish Kumar Yadav, Narendra Kumar, Abdul Talim Khan, Rajesh Kushwaha, Samya Banerjee
Summary: Sonodynamic therapy (SDT) using ultrasound (US) as the drug stimulus has emerged as a potential alternative to photodynamic therapy (PDT) to treat deep-seated tumors with higher tissue penetration capacity. While organic molecules and nanomaterials are commonly used as sonosensitizers in SDT, the potential of metal complexes in this area remains underexplored. Recent literature reports have shown the high potential of metal complexes as sonosensitizers in SDT.
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Ai Ouyang, Zhuanglin Shen, Zhihao Pan, Samya Banerjee, Qianling Zhang, Yantao Chen, Pingyu Zhang
Summary: In this study, a sonosensitizer AuNPs@Ir1 was developed by hybridizing an organometallic Ir(III) complex with ultrasmall gold nanoparticles for efficient tumor sonodynamic therapy. AuNPs@Ir1 rapidly entered cancer cells under ultrasound irradiation and induced cancer cell oncosis. The results demonstrated the excellent in-vitro and in-vivo anticancer profile of AuNPs@Ir1, which has the potential to expand the scope of sonodynamic therapy for metal-based anticancer drugs.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Zhongxian Fan, Yi Rong, Tumpa Sadhukhan, Shaoxia Liang, Wenqing Li, Zhanxiang Yuan, Zilin Zhu, Shunwen Guo, Shaomin Ji, Jinquan Wang, Rajesh Kushwaha, Samya Banerjee, Krishnan Raghavachari, Huaiyi Huang
Summary: The uptake and retention of Ir-III photoredox catalysts were studied in single cancer cells using single-cell inductively coupled plasma mass spectrometry. The dinuclear catalyst showed significant synergism and high photocatalytic therapeutic efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Anyi Dao, Ashish Kumar Yadav, Li Wei, Samya Banerjee, Huaiyi Huang
Summary: This research introduces the latest studies on anti-tumor strategies achieved by the combination of immunotherapy and photodynamic therapy through photo-pyroptosis. Pyroptosis, a programmed cell death, is able to enhance anti-tumor immunity by producing inflammatory cytokines.
Article
Oncology
Imran Khan, Brunilde Gril, Ayuko Hoshino, Howard H. Yang, Maxwell P. Lee, Simone Difilippantonio, David C. Lyden, Patricia S. Steeg
Summary: This study demonstrates that tumor-derived exosomes can suppress metastasis by delivering the NME1 metastasis suppressor to recipient tumor cells, resulting in altered endocytic patterns and reduced cell motility and migration. Proteomic analysis of the exosomes identified differentially expressed proteins that may contribute to these effects. Liposomes containing rNME1 also exhibited similar suppressive effects. These findings expand our understanding of the functions of exosomes and liposomes and provide a novel approach to prevent metastasis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Chemistry, Inorganic & Nuclear
Bhabatosh Banik, Akash Ashokan, Joshua H. H. Choi, Bapurao Surnar, Shanta Dhar
Summary: Cisplatin, a key player in chemotherapy, has been improved by developing new platinum-based prodrugs with active ligands. Platin-C, a platinum(iv)-based prodrug tethered to curcumin, showed enhanced chemotherapeutic efficacy and targeted mitochondria of cancer cells. It also demonstrated the ability to attenuate cellular inflammation.
DALTON TRANSACTIONS
(2023)
Article
Computer Science, Information Systems
Akhtar Hussain, Van-Hai Bui, Hak-Man Kim
Summary: A dynamic pricing model is proposed to manage EV loads locally and mitigate equipment overloading in distribution systems. The model considers the sensitivity of EV owners to battery state of charge and urgency of recharge, and the welfare of the EV fleet operator in terms of net load and electricity price. The proposed method achieves privacy preservation and has shown effectiveness in mitigating transformer overloading during peak load hours.
Review
Computer Science, Information Systems
Masooma Nazari, Akhtar Hussain, Petr Musilek
Summary: The growing penetration of electric vehicles presents challenges for power systems, especially distribution systems, due to uncertain load. Clustering methods can address this problem, and previous studies have applied clustering methods to various aspects of electric vehicles. This contribution reviews existing clustering methods, discusses their application in different aspects of electric vehicles, and identifies gaps and future research directions.
Article
Chemistry, Inorganic & Nuclear
Alexandra Sink, Samya Banerjee, Juliusz A. Wolny, Cinzia Imberti, Edward C. Lant, Marc Walker, Volker Schuenemann, Peter J. Sadler
Summary: Activation of methyl C-H bonds in half-sandwich Rh(III) complexes and their catalytic properties were investigated, key steps in the catalytic mechanism were revealed via DFT calculations, providing new insights for the design of the next generation of molecular machines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Zilin Zhu, Li Wei, Yidan Lai, Oliver W. L. Carter, Samya Banerjee, Peter J. Sadler, Huaiyi Huang
Summary: Rationally-designed glucose-appended Ir(III) photocatalysts were found to exhibit visible light-induced catalytic NAD(P)H oxidation in aqueous solution. Among them, the highly in vivo biocompatible complex Ir3 showed lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids while remaining non-toxic in the dark.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Rajesh Kushwaha, Ashish Kumar, Souvik Saha, Sumit Bajpai, Ashish Kumar Yadav, Samya Banerjee
Summary: In response to the increasing mortality rate associated with cancer and the limitations of Pt-based chemotherapeutics, the concept of catalytic anticancer agents has been introduced, showing promising results with Os(ii) complexes in disrupting essential intracellular processes in cancer cells, ultimately leading to cell death. These complexes have the potential to be novel catalytic cancer drugs with unique anticancer mechanisms.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Feng Chen, Isolda Romero-Canelon, Abraha Habtemariam, Ji-Inn Song, Samya Banerjee, Guy J. Clarkson, Lijiang Song, Ivan Prokes, Peter J. Sadler
Summary: We synthesized a series of novel substituted sulfonyl ethylenediamine (en) Ru-II arene complexes, which showed antiproliferative activity against cancer cells and exhibited catalytic activity in transfer hydrogenation reactions and reactions with thiols.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Arun Kumar, Samya Banerjee, Nishant Sharma, Mohd Nazish, Nico Graw, Regine Herbst-Irmer, Dietmar Stalke, Upakarasamy Lourderaj, Herbert W. Roesky
Summary: Amidinate compounds with stabilized aluminium(II) and gallium(II) elements were synthesized by prepared their precursors, and insights into their bonding were gained through the study.
DALTON TRANSACTIONS
(2022)