4.5 Article

Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria

期刊

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 13, 页码 1739-1745

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.200801159

关键词

Silver; Carbenes; N-Heterocyclic carbenes; Burkholderia; Antibiotics; Nitrogen heterocycles

资金

  1. University of Akron
  2. Washington University School of Medicine
  3. National Institute of Allergies and Infectious Diseases [1 R01 A106785601]
  4. The National Institute of General Medical Sciences [1 R01 GM8689501]
  5. National Institutes of Health (NIH) [U54 A1057156]
  6. NIH/NIAID
  7. Task Order 19 (Part-C) [N01-AI-30065]
  8. National Science Foundation [CHE-0341701, DMR-0414599, 0116041]
  9. Ohio Board of Regents
  10. Division Of Chemistry
  11. Direct For Mathematical & Physical Scien [0116041] Funding Source: National Science Foundation

向作者/读者索取更多资源

A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of biosafety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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