Article
Biochemistry & Molecular Biology
Marlena Typiak, Piotr Trzonkowski, Monika Skotarczak, Anna Dubaniewicz
Summary: Sarcoidosis (SA) is a granulomatous disorder that affects the lungs, resembling tuberculosis (TB) in clinical characteristics but with different treatment approaches. By studying the phagocytic activity of monocytes in the blood of SA and TB patients using flow cytometry, we found higher phagocytic activity in SA patients and an increased frequency of Fc?RIII (CD16) receptors but a decreased frequency of CR1 (CD35) receptors compared to TB patients. This study provides insights into the pathomechanisms and differential diagnosis of SA and TB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Guillaume Beaudoin-Bussieres, Ariana Arduini, Catherine Bourassa, Halima Medjahed, Gabrielle Gendron-Lepage, Jonathan Richard, Qinghua Pan, Zhen Wang, Chen Liang, Andres Finzi
Summary: Viruses employ various strategies to evade host immune responses, and SARS-CoV-2 uses Spike mutation and ORF8-mediated reduction of CD16 to escape immunity. ORF8 binds monocytes and NK cells, leading to decreased CD16 levels and impaired cellular cytotoxicity.
Article
Immunology
Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Summary: This study uses an ordinary differential equation model to quantitatively assess the influence of IgG1 allotypes and Fc gamma R polymorphisms on IgG-Fc gamma RIIIa complex formation in vaccine-relevant settings. The results demonstrate that specific vaccine interventions can enhance IgG-Fc gamma RIIIa complex formation in different genetic backgrounds.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rebekah Sherburn, William D. Tolbert, Suneetha Gottumukkala, Andrew P. Hederman, Guillaume Beaudoin-Bussieres, Sherry Stanfield-Oakley, Marina Tuyishime, Guido Ferrari, Andres Finzi, Margaret E. Ackerman, Marzena Pazgier
Summary: The research has shown that vaccination strategies inducing non-neutralizing or weakly neutralizing antibodies with potent Fc-effector functions have been partially successful in preventing and controlling HIV-1 infection. By incorporating V1V2 domain into the ID2 antigen, the newly generated ID2-V1V2 vaccine immunogen significantly enhances the Fc-mediated effector functions, showing promise as a candidate for HIV-1 vaccine development.
Article
Immunology
Carina Lynn Gehlert, Pegah Rahmati, Ammelie Svea Boje, Dorothee Winterberg, Steffen Krohn, Thomas Theocharis, Elisa Cappuzzello, Anja Lux, Falk Nimmerjahn, Ralf J. Ludwig, Marta Lustig, Thies Roesner, Thomas Valerius, Denis Martin Schewe, Christian Kellner, Katja Klausz, Matthias Peipp
Summary: This study engineered a CD19 antibody to enhance effector cell-mediated killing and CDC activity. The dual optimized CD19 antibody showed improved ADCC, ADCP, and CDC compared to the non-engineered antibody. This finding is crucial for improving CD19-directed cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bruce D. Wines, Halina M. Trist, Sandra Esparon, Rachael E. Impey, Graham A. Mackay, Robert K. Andrews, Tatiana P. Soares da Costa, Geoffrey A. Pietersz, Ross Baker, P. Mark Hogarth
Summary: The activation of Fc gamma RIIa by monoclonal antibodies requires interaction with both the Fab and Fc regions simultaneously on the same receptor molecules.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Da-Wei Chen, Tian Kang, Xiu-Zhang Xu, Wen-Jie Xia, Xin Ye, Yong-Bin Wu, Yao-Ri Xu, Jing Liu, Hui Ren, Jing Deng, Yang-Kai Chen, Hao-Qiang Ding, Muhammad Aslam, Wioleta M. Zelek, B. Paul Morgan, Rick Kapur, Sentot Santoso, Yong-Shui Fu
Summary: Anti-CD36 antibodies can cause transfusion-related acute lung injury (TRALI), especially in Asian populations. However, the pathological mechanism of anti-CD36 Ab-mediated TRALI and potential therapies are not well understood. In this study, a mouse model of anti-CD36 Ab-mediated TRALI was developed, and it was found that TRALI could be prevented and treated by targeting Fc and complement C5 activation. These findings suggest the potential for anti-C5 drugs in the treatment of TRALI caused by anti-CD36 antibodies.
Article
Immunology
Anna Louisa Thaller, Friederike Jonsson, Oriane Fiquet, Solenne Marie, Jean-Marc Doisne, Giulia Girelli-Zubani, Toshiki Eri, Priyanka Fernandes, Evgeny Tatirovsky, Francina Langa-Vives, Pierre Bruhns, Helene Strick-Marchand, James P. Di Santo
Summary: Human immune system (HIS) mice are used to study human immune responses in vivo. A new FcR-γ-deficient HIS mouse model was created to compare host (mouse) versus graft (human) effects in antibody-mediated immune responses in vivo.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J. Thompson, Peter A. Revill, P. Mark Hogarth, Bruce D. Wines, Renae Walsh, Nadia Warner
Summary: This study identified key anti-HBs profiles associated with either functional cure or failure to achieve functional cure in patients with chronic hepatitis B, suggesting a role for anti-HBs responses in functional cure.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Basudev Paudyal, William Mwangi, Pramila Rijal, John C. Schwartz, Alistair Noble, Andrew Shaw, Joshua E. Sealy, Marie Bonnet-Di Placido, Simon P. Graham, Alain Townsend, John A. Hammond, Elma Tchilian
Summary: The pig, an important agricultural species and biomedical model, has been established as a robust model for testing therapeutic antibodies due to its physiological similarities to humans. This study investigated the Fc-mediated functions of porcine IgG subclasses, and found that different subclasses exhibit variations in cell binding and mediating cellular cytotoxicity and phagocytosis. The results enhance the utility of the pig model in therapeutic antibody research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Muller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendeus, Ramsey Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Summary: Hypoxia in the tumor microenvironment can upregulate the expression of Fc gamma RIIb receptors on tumor-associated macrophages (TAMs), which leads to reduced antibody dependent cellular phagocytosis (ADCP) and decreased efficacy of monoclonal antibody (mAb) immunotherapy. This finding provides a mechanistic basis for targeting Fc gamma RIIb expression or blocking it as a promising strategy for enhancing mAb immunotherapies.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Neurosciences
Sanam Mustafa, Juliana E. Bajic, Benjamin Barry, Samuel Evans, Kariel R. Siemens, Mark R. Hutchinson, Peter M. Grace
Summary: The transition from acute to chronic pain is a major challenge in pain management, and the immune system plays a crucial role in this process. Understanding the dynamic and adaptable characteristics of the immune system is essential for developing new strategies to manage and treat chronic pain.
Article
Immunology
Adrian Elter, Desislava Yanakieva, David Fiebig, Kerstin Hallstein, Stefan Becker, Ulrich Betz, Harald Kolmar
Summary: This study introduces a novel Fc-tamed antibody format, which reduces off-target toxicity by blocking the Fc gamma R-binding sites of antibodies, resulting in decreased activation and improved safety profiles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Hannes Vietzen, Vera Danklmaier, Alexander Zoufaly, Elisabeth Puchhammer-Stockl
Summary: This study investigates the role of genetic variants in activating natural killer (NK) cell receptors in contributing to the severity of COVID-19. The study shows that the high-affinity variant of the Fc gamma RIIIa receptor is over-represented in hospitalized and deceased patients with COVID-19, while the low-affinity variant is more common in patients with mild COVID-19. Additionally, functional assays reveal that hospitalized patients with COVID-19 exhibit significantly higher proinflammatory ADCC responses, particularly in NK cells expressing the high-affinity variant of the Fc gamma RIIIa receptor.
GENETICS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Anurag Adhikari, Auda Eltahla, Andrew R. Lloyd, Chaturaka Rodrigo, David Agapiou, Rowena A. Bull, Nicodemus Tedla
Summary: This study established a flow-cytometry based ADCP assay for HCV infection using E2-protein coated microbeads and found that patients with genotype 1 and genotype 3 HCV infection had significantly higher levels of ADCP compared to healthy controls. There was a significant correlation between increase in ADCP and higher concentrations of anti-E2 IgG antibodies in the plasma of patients.
JOURNAL OF IMMUNOLOGICAL METHODS
(2021)
Letter
Immunology
Tim Niehues, Tuba Turul Oezguer, Marie Bickes, Rebecca Waldmann, Jennifer Schoening, Jan Braesen, Christian Hagel, Matthias Ballmaier, Jan-Henning Klusmann, Alexandra Niedermayer, Ulrich Pannicke, Anselm Enders, Gregor Dueckers, Kathrin Siepermann, Julyia Hempel, Klaus Schwarz, Dorothee Viemann
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Clinical Neurology
Nicole Moschny, Kirsten Jahn, Hannah Benedictine Maier, Abdul Qayyum Khan, Matthias Ballmaier, Kyra Liepach, Mareike Sack, Thomas Skripuletz, Stefan Bleich, Helge Frieling, Alexandra Neyazi
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Immunology
Abdul W. Ansari, Fareed Ahmad, Esaki M. Shankar, Yean K. Yong, Hong Y. Tan, Roland Jacobs, Marie Larsson, Vijayakumar Velu, Adeeba Kamarulzaman, Reinhold E. Schmidt
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2020)
Article
Medicine, General & Internal
Alexandra Jablonka, Haress Etemadi, Ignatius Ryan Adriawan, Diana Ernst, Roland Jacobs, Sabine Buyny, Torsten Witte, Reinhold Ernst Schmidt, Faranaz Atschekzei, Georgios Sogkas
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Catharina Melzer, Roland Jacobs, Thomas Dittmar, Andreas Pich, Juliane von der Ohe, Yuanyuan Yang, Ralf Hass
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Microbiology
Sebastian J. Theobald, Christoph Kreer, Sahamoddin Khailaie, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Michael Mach, Marija Backovic, Matthias Ballmaier, Johannes Koenig, Henning Olbrich, Andreas Schneider, Valery Volk, Simon Danisch, Lutz Gieselmann, Meryem Seda Ercanoglu, Martin Messerle, Constantin von Kaisenberg, Torsten Witte, Frank Klawonn, Michael Meyer-Hermann, Florian Klein, Renata Stripecke
Article
Psychiatry
Nicole Moschny, Kirsten Jahn, Malek Bajbouj, Hannah Benedictine Maier, Matthias Ballmaier, Abdul Qayyum Khan, Christoph Pollak, Stefan Bleich, Helge Frieling, Alexandra Neyazi
FRONTIERS IN PSYCHIATRY
(2020)
Article
Clinical Neurology
Dominica Ratuszny, Thomas Skripuletz, Florian Wegner, Matthias Gross, Christine Falk, Roland Jacobs, Heiner Ruschulte, Martin Stangel, Kurt-Wolfram Suehs
FRONTIERS IN NEUROLOGY
(2020)
Article
Biology
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy Koenig, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene
Summary: Expression levels of CX3CR1 on immune cells play a significant role in maintaining tissue homeostasis under physiological and pathological conditions. Recent studies suggest that misfolded proteins, such as polymers or amyloid fibrils, can regulate CX3CR1 expression, providing evidence for involvement in Z-AAT-related disorders. This highlights the importance of understanding the role of misfolded proteins in regulating CX3CR1.
Article
Hematology
Manuela Germeshausen, Matthias Ballmaier
Summary: CAMT is a rare inherited bone marrow failure syndrome characterized by mutations in the MPL gene. The disease has complex etiologies, with associations with radio-ulnar synostosis and the possibility of misdiagnosis with other IBMFS.
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
(2021)
Article
Immunology
Deepti Singh, Paul C. Guest, Henrik Dobrowolny, Veronika Vasilevska, Gabriela Meyer-Lotz, Hans-Gert Bernstein, Katrin Borucki, Alexandra Neyazi, Bernhard Bogerts, Roland Jacobs, Johann Steiner
Summary: This study found that levels of neutrophils and C-reactive protein were higher, while eosinophils were lower in patients with major depression compared to controls. The changes in neutrophil and eosinophil counts were smaller in major depression compared to schizophrenia. These findings suggest that innate immunity may be involved in early stages of major depression, while adaptive immunity may be involved in chronic disease.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Microbiology
Samuel A. A. Osanyinlusi, Jasmin Zischke, Roland Jacobs, Eva M. M. Weissinger, Thomas F. F. Schulz, Penelope C. C. Kay-Fedorov
Summary: Human cytomegalovirus (HCMV) inhibits T cell antiviral functions by interacting with CD45 on T cells via its pUL11 glycoprotein, leading to enhanced viral spread. This discovery provides insights into HCMV's immunomodulatory strategy and a new T cell regulatory mechanism.
Article
Medicine, General & Internal
Dominique Josephine Dimmek, Christoph Korallus, Sabine Buyny, Gutenbrunner Christoph, Ralf Lichtinghagen, Roland Jacobs, Boya Nugraha
Summary: The study found that BDNF levels are significantly lower in pain patients, and there are significant differences in subpopulations of immune cells between different groups. Compared to healthy subjects, all chronic pain patients showed significantly lower numbers of CD4(+) CD8(+) T cells, CD3(-) CD56(bright) NK cells, and CD20(+) CD3(-) cells.
MEDICINA-LITHUANIA
(2021)
Article
Clinical Neurology
Nora Mohn, Mike P. Wattjes, Ortwin Adams, Sandra Nay, Daria Tkachenko, Friederike Salge, Johanne Heine, Kaweh Pars, Gunter Hoglinger, Gesine Respondek, Martin Stangel, Thomas Skripuletz, Roland Jacobs, Kurt-Wolfram Suhs
Summary: Reactivation of human JC polyoma virus (JCPyV) leads to progressive multifocal leukoencephalopathy (PML) caused mainly by immunosuppression, resulting in various neurological deficits. Currently, there is no effective therapy for PML.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Editorial Material
Cell Biology
Stefan Gingele, Thomas Skripuletz, Roland Jacobs
NEURAL REGENERATION RESEARCH
(2020)