期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 43, 期 12, 页码 3156-3158出版社
WILEY
DOI: 10.1002/eji.201344131
关键词
C-type lectin; Mincle; Myeloid cells; Signaling adaptor
类别
Recently, C-type lectin receptors (CLRs) have been identified as a newly emerging family of pattern-recognition receptors for pathogen-associated molecular patterns. The ligand and function of many individual CLRs have been clarified in the past few years. A new report by Lobato-Pascual et al. in this issue of the European Journal of Immunology [Eur. J. Immunol. 2013. 43: 3167-3174] shows that a rat CLR, named macrophage C-type lectin (also called Clec4d), forms a heterodimer with another CLR, macrophage inducible C-type lectin (also called Clec4e). This finding sheds light on a possible synergistic regulation of different C-type lectin receptors by forming heterodimers: such heterodimers may amplify signaling, expand ligand specificity, or confer multiple functions.
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