期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 43, 期 8, 页码 2078-2088出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201343338
关键词
Age; Experimental autoimmune encephalomyelitis; Innate immunity; Multiple sclerosis; Susceptibility
类别
资金
- Else Kroner Fresenius Stiftung [A69/2010]
- Deutsche Forschungsgemeinschaft (DFG) [WE 3547/4-1]
- US National Multiple Sclerosis Society (NMSS) [PP 1660]
- ProFutura program of the University of Gottingen
MS is an inflammatory CNS disorder, which typically occurs in early adulthood and rarely in children. Here we tested whether functional maturation of innate immune cells may determine susceptibility to CNS autoimmune disease in EAE. Two-week-old mice were resistant to active EAE, which causes fulminant paralysis in adult mice; this resistance was associated with an impaired development of Th1 and Th17 cells. Resistant, young mice had higher frequencies of myeloid-derived suppressor cells and plasma-cytoid DCs. Furthermore, myeloid APCs and B cells from young mice expressed lower levels of MHC class II and CD40, produced decreased amounts of proinflammatory cytokines, and released enhanced levels of anti-inflammatory IL-10. When used as APCs, splenocytes from 2-week-old mice failed to differentiate naive T cells into Th1 and Th17 cells irrespective of the T-cell donor's age, and promoted development of Treg cells and Th2 cells instead. Adoptive transfer of adult APCs restored the ability of 2-week-old mice to generate encephalitogenic T cells and develop EAE. Collectively, these findings indicate that the innate immune compartment functionally matures during development, which may be a prerequisite for development of T-cell-mediated CNS autoimmune disease.
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