Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

(2013) James D Mellor et al.   Journal of Hematology & Oncology

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor

(2012) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cell reprogramming by the hypoxic environment

(2012) Maria Carla Bosco et al.   IMMUNOBIOLOGY

Altered phenotype in peripheral blood and tumor-associated NK cells from colorectal cancer patients

(2012) Yamila S Rocca et al.   Innate Immunity

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

(2011) S. Platonova et al.   CANCER RESEARCH

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma

(2011) J. H. W. Pahl et al.   CLINICAL CANCER RESEARCH

Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines

(2011) N. Halama et al.   CLINICAL CANCER RESEARCH

Oxygen tension regulates NK cells differentiation from hematopoietic stem cells in vitro

(2011) Sohyun Yun et al.   IMMUNOLOGY LETTERS

NK cells and their receptors during viral infections

(2011) Emanuela Marcenaro et al.   Immunotherapy

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection

(2011) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural Killer Cells and Solid Tumors

(2011) Ana Stojanovic et al.   Journal of Innate Immunity

Hypoxia: a double-edged sword of immunity

(2011) Antonio Sica et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors

(2011) R. P. Veeranna et al.   JOURNAL OF VIROLOGY

Natural killer cells: fighting viruses and much more

(2011) Marco Colonna et al.   NATURE IMMUNOLOGY

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Activation of NK Cells by ADCC Responses During Early HIV Infection

(2011) Amy W. Chung et al.   VIRAL IMMUNOLOGY

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

(2010) G. Magri et al.   BLOOD

Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation

(2010) L. Moretta et al.   BLOOD

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

(2010) Paolo Fardin et al.   Molecular Cancer

Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators

(2010) Amber T Washington et al.   Virology Journal

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2

(2009) Jintang Sun et al.   Cellular & Molecular Immunology

Natural killer cells kill human melanoma cells with characteristics of cancer stem cells

(2009) G. Pietra et al.   INTERNATIONAL IMMUNOLOGY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

(2009) Tadepally Lakshmikanth et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced In Vivo Growth of Lymphoma Tumors in the Absence of the NK-Activating Receptor NKp46/NCR1

(2009) G. G. Halfteck et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Prolongs Monocyte/Macrophage Survival and Enhanced Glycolysis Is Associated with Their Maturation under Aerobic Conditions

(2009) J. Roiniotis et al.   JOURNAL OF IMMUNOLOGY

NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties

(2009) R. Castriconi et al.   JOURNAL OF IMMUNOLOGY

Natural killer cell-based immunotherapy in cancer: current insights and future prospects

(2009) T. Sutlu et al.   JOURNAL OF INTERNAL MEDICINE

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human natural killer cells

(2008) M. A. Caligiuri   BLOOD

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration

(2008) Maria Carla Bosco et al.   IMMUNOBIOLOGY

Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1  and -2 

(2008) M. Puppo et al.   MOLECULAR CANCER THERAPEUTICS

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE