Review
Allergy
Alison G. Stanbery, Shuchi Smita, Jakob von Moltke, Elia D. Tait Wojno, Steven F. Ziegler
Summary: The release of cytokines from epithelial and stromal cells plays a critical role in tissue immunity, with thymic stromal lymphopoietin, IL-33, and IL-25 being important regulators of type 2 immune responses. These tissue-associated cytokines not only contribute to canonical type 2 responses but also play roles in viral infections, cancer, and homeostasis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Arwa Al Kindi, Helen Williams, Kenshiro Matsuda, Abdullah M. Alkahtani, Charis Saville, Hayley Bennett, Yasmine Alshammari, Soo Y. Tan, Catherine O'Neill, Akane Tanaka, Hiroshi Matsuda, Peter D. Arkwright, Joanne L. Pennock
Summary: The study identified Sbi as a key virulence factor derived from Staphylococcus aureus, capable of inducing the release of IL-33 from human keratinocytes to promote type 2 immune responses underlying atopic dermatitis. This study sheds light on the mechanism of how S. aureus drives allergic pathology in AD patients in the absence of infection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Xiuju Dai, Jun Muto, Ken Shiraishi, Ryo Utsunomiya, Hideki Mori, Masamoto Murakami, Koji Sayama
Summary: Atopic dermatitis (AD) is an inflammatory skin disease characterized by skin barrier dysfunction. This study found that TSLP plays a promoting role in AD development by activating T helper type 2 responses and affecting the integrity of the epidermal barrier.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying-Yi Lu, Chun-Ching Lu, Chao-Lan Huang, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin Wu
Summary: This study found that linalyl acetate (LA) can alleviate mechanical hyperalgesia caused by neuropathic pain by modulating TSLP/TSLPR and IL-33 signaling. The findings provide a new potential approach for treating neuropathic pain.
NEUROCHEMICAL RESEARCH
(2022)
Article
Allergy
Eric B. Brandt, Brandy P. Ruff, Alyssa L. Filuta, Wan-Chi Chang, Dana Shik, Gurjit K. Khurana Hershey
Summary: The study evaluates the roles of TSLP and IL-33 in the development of AD and food allergy in mice models. The results suggest that TSLP and IL-33 have different contributions to the development of food allergy, and TSLP shows potential in early prevention of AD and food allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Eva Poveda, Wendy Fitzgerald, Cristina Reglero, Alexandre Perez-Gonzalez, Ana Marino, Hortensia Alvarez, Nieves Valcarce, Josep Maria Llibre, Santiago Moreno Guillen, Maria Angeles Munoz Fernandez, Ezequiel Ruiz-Mateos, Leonid Margolis, Michael M. Lederman, Michael L. Freeman
Summary: Elite controllers (EC) had higher levels of plasma extracellular vesicle (EV)-associated cytokines compared to other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 could distinguish EC from ART-treated individuals, while EV-associated IL-3 and TRAIL could distinguish PC from TC. Further investigation is needed to understand the role of EV-cytokines in intercellular communication and endogenous control of HIV expression.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Guiping Zhu, Hui Cai, Ling Ye, Yuqing Mo, Mengchan Zhu, Yingying Zeng, Xixi Song, Chengyu Yang, Xin Gao, Jian Wang, Meiling Jin
Summary: This study reveals the regulatory role of SPRR3 in allergic airway inflammation and identifies it as a potential novel therapeutic target for asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Jin, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Chang Ho Song, So-Yong Lee, Hee Soon Shin, Ok Hee Chai
Summary: This study found that Fallopia japonica root extract (FJE) has therapeutic effects on airway inflammation associated with allergic rhinitis and asthma. It reduces the production of inflammatory cells and pro-inflammatory cytokines, improves histopathological characteristics, and modulates the IL-33/TSLP/NF-B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang
Summary: The study discovered that by inhibiting thrombin, the maturation of IL-33 can be regulated, thus impacting ILC2s cells and treating lung inflammation.
Editorial Material
Immunology
Lewis W. Yu, Elaine Y. Hsiao
Summary: This study reveals how immune signals can indirectly modulate enteric function through neurotransmitter regulation, promoting gut motility by inducing intestinal serotonin.
Editorial Material
Immunology
Elizabeth A. Kennedy, Kellie Ann Jurado
Summary: This article investigates the unclear mechanisms of labor initiation and highlights the significance of timely labor for infant and maternal health. Siewiera et al. demonstrate the crucial role of innate type 2 immune responses in controlling uterus-intrinsic onset of labor in mice.
Editorial Material
Immunology
Hirohito Kita
Summary: This passage describes the transfer of IL-33 from the nucleus to the cytoplasm and its extracellular release through gasdermin D pores in airway epithelial cells exposed to allergen proteases.
Review
Immunology
Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and current immunotherapeutic interventions have limited effectiveness. Cytokines interleukin-25 (IL-25) and IL-33, expressed by barrier epithelial cells, play important roles in the intestinal immune responses and can influence tumorigenesis in CRC. IL-25 and IL-33 have different effects on different subtypes of CRC and can modulate various immune cell types and pathways, including angiogenesis, tumor stemness, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
