Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zhussipbek Mukhatayev, Yekaterina O. Ostapchuk, Deyu Fang, I. Caroline Le Poole
Summary: Regulatory T cells (Tregs) play a crucial role in autoimmune skin diseases, and alterations in their numbers and functions can lead to various conditions. The use of antigen-specific Tregs engineered cells shows promise in improving treatment efficacy, though challenges in clinical applications need to be addressed.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
David W. Scott
Summary: The use of CAR transduced T cells and engineered Tregs with specific receptors show great promise in cancer immunotherapy. Methods involving retroviral transduction of specific T-cell receptors, scFv, or antigens for various diseases models are discussed for their potential clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Engineering, Multidisciplinary
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Summary: Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that redirect cells to specific targets. They have been shown to improve accuracy, potency, and reduce off-target effects in cancer therapy. Regulatory T cells (Tregs) are important in suppressing immune activation and regulating the immune response. CAR-Tregs hold potential for treating autoimmune diseases, GVHD, and organ transplant rejection.
Article
Chemistry, Multidisciplinary
Mungyo Jung, Songmin Lee, Sohui Park, Jihye Hong, Cheesue Kim, Illhwan Cho, Hee Su Sohn, Kyunghwan Kim, In Wook Park, Soljee Yoon, Sungpil Kwon, Jisu Shin, Donghee Lee, Mikyung Kang, Seokhyung Go, Sangjun Moon, Yeonseok Chung, YoungSoo Kim, Byung-Soo Kim
Summary: Alzheimer's disease, the most common cause of dementia, has multiple pathophysiological mechanisms. Current immunotherapy approaches targeting single mechanism have limitations. A nanovaccine has been developed to target multiple mechanisms and show higher efficacy in treating Alzheimer's disease in mice. The nanovaccine is easy-to-prepare and cost-effective, providing a novel treatment option for Alzheimer's disease.
ADVANCED MATERIALS
(2023)
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley, Howard E. Gendelman
Summary: The study showed that introducing antigen specificity into regulatory T cells (Tregs) through engineering T cell receptors (TCRs) can reduce amyloid-beta (Aβ) burden and improve learning and memory, suggesting the potential therapeutic benefit of antigen-specific Treg immunotherapy for Alzheimer's disease.
MOLECULAR NEURODEGENERATION
(2023)
Article
Allergy
Daniel Lozano-Ojalvo, Scott R. Tyler, Carlos J. Aranda, Julie Wang, Scott Sicherer, Hugh A. Sampson, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y. M. Leung, Maria Curotto de Lafaille, M. Cecilia Berin
Summary: This study observed that oral immunotherapy can increase the frequency of Tregs in individuals with lasting clinical tolerance. It also found that the release of IL-2 from Th2 effector cells can induce delayed and persistent activation of Tregs, which could be significant for improving current oral immunotherapy approaches.
Article
Immunology
Dorota Iwaszkiewicz-Grzes, Magdalena Piotrowska, Mateusz Gliwinski, Zuzanna Urban-Wojciuk, Piotr Trzonkowski
Summary: The study revealed that insulin beta chain peptide 9-23 favored specific Tregs expression, while whole insulin activated both Tregs and Teffs. Tregs SPECB:9-23 showed the highest level of expression in crucial genes and lower methylation levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
HyeJin Yang, Seon-Young Park, Hyunjung Baek, Chanju Lee, Geehoon Chung, Xiao Liu, Ji Hwan Lee, Byungkyu Kim, Minjin Kwon, Hyojung Choi, Hyung Joon Kim, Jae Yoon Kim, Younsub Kim, Ye-Seul Lee, Gaheon Lee, Sun Kwang Kim, Jin Su Kim, Young -Tae Chang, Woo Sang Jung, Kyung Hwa Kim, Hyunsu Bae
Summary: AP antigen-specific regulatory T cells can suppress microglial proinflammatory activity and modulate microglial phenotype via bystander suppression. Single adoptive transfer of AP+ Tregs is sufficient to ameliorate cognitive impairments, AP accumulation, hyper-phosphorylation of tau, and neuroinflammation during AD pathology. AP-specific Tregs effectively inhibit inflammation in primary microglia induced by AP exposure, indicating bystander suppression where AP-specific Tregs promote immune tolerance by secreting cytokines to modulate immune responses during neurodegeneration.
Review
Immunology
Claudia Selck, Margarita Dominguez-Villar
Summary: Regulatory T (Treg) cells are a diverse population of immunosuppressive T cells with therapeutic potential for treating autoimmune diseases and graft rejection. Antigen-specific Treg cells have shown to be more effective in disease-specific regulation, but face challenges such as the identification of disease-relevant antigens and the stability of cells post-transfer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Edgar Angelats, Pere Santamaria
Summary: TR1 cells are an immunosuppressive T cell subset that produces high levels of IL-10. Recent studies suggest that TR1 cells have potential therapeutic applications in immune-mediated diseases. However, the developmental biology of TR1 cells remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Navid Sobhani, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li
Summary: Immunotherapies have shown promise in cancer treatment but face challenges. Understanding the molecular mechanisms of immune checkpoint inhibitors and the role of regulatory T cells is crucial for improving cancer therapies.
Review
Biochemistry & Molecular Biology
Shuaifeng Yan, Konstantin Kotschenreuther, Shuya Deng, David M. Kofler
Summary: Rheumatoid arthritis is an autoimmune disease that affects joints and causes systemic inflammation. Regulatory T cells play a crucial role in disease onset, and their functions and frequency are reduced in autoimmune diseases. Therefore, increasing and restoring the functions of these cells is a promising strategy for the treatment of rheumatoid arthritis. Current research in this field focuses on RA patients and animal models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hee Su Sohn, Jeong Won Choi, JooYeon Jhun, Sung Pil Kwon, Mungyo Jung, Sangmin Yong, Hyun Sik Na, Jin-Hong Kim, Mi-La Cho, Byung-Soo Kim
Summary: This study describes an immunomodulating nanoparticle for the treatment of osteoarthritis. Injecting these nanoparticles into the joints of mice effectively suppressed inflammation, reduced inflammatory cells and cytokines, and improved the condition of chondrocytes, leading to pain relief.
Article
Biochemistry & Molecular Biology
Pervinder Sagoo, Zacarias Garcia, Beatrice Breart, Fabrice LemaOtre, David Michonneau, Matthew L. Albert, Yves Levy, Philippe Bousso
Article
Immunology
David Michonneau, Pervinder Sagoo, Beatrice Breart, Zacarias Garcia, Susanna Celli, Philippe Bousso
Editorial Material
Immunology
Ehsan Sharif-Paghaleh, John Leech, Kavitha Sunassee, Niwa Ali, Pervinder Sagoo, Robert I. Lechler, Lesley A. Smyth, Giovanna Lombardi, Gregory E. Mullen
EUROPEAN JOURNAL OF IMMUNOLOGY
(2014)
Article
Hematology
Cristiano Scotta, Marianna Esposito, Henrieta Fazekasova, Giorgia Fanelli, Francis C. Edozie, Niwa Ali, Fang Xiao, Mark Peakman, Behdad Afzali, Pervinder Sagoo, Robert I. Lechler, Giovanna Lombardi
Article
Immunology
Giovanna Lombardi, Pervinder Sagoo, Cristiano Scotta, Henrieta Fazekasova, Lesley Smyth, Julia Tsang, Behdad Afzali, Robert Lechler
Article
Medicine, Research & Experimental
Pervinder Sagoo, Esperanza Perucha, Birgit Sawitzki, Stefan Tomiuk, David A. Stephens, Patrick Miqueu, Stephanie Chapman, Ligia Craciun, Ruhena Sergeant, Sophie Brouard, Flavia Rovis, Elvira Jimenez, Amany Ballow, Magali Giral, Irene Rebollo-Mesa, Alain Le Moine, Cecile Braudeau, Rachel Hilton, Bernhard Gerstmayer, Katarzyna Bourcier, Adnan Sharif, Magdalena Krajewska, Graham M. Lord, Ian Roberts, Michel Goldman, Kathryn J. Wood, Kenneth Newell, Vicki Seyfert-Margolis, Anthony N. Warrens, Uwe Janssen, Hans-Dieter Volk, Jean-Paul Soulillou, Maria P. Hernandez-Fuentes, Robert I. Lechler
JOURNAL OF CLINICAL INVESTIGATION
(2010)
Article
Immunology
Lesley A. Smyth, Kulachelvy Ratnasothy, Aurelie Moreau, Sally Alcock, Pervinder Sagoo, Lucy Meader, Yakup Tanriver, Matthew Buckland, Robert Lechler, Giovanna Lombardi
JOURNAL OF IMMUNOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Ke Li, Henrieta Fazekasova, Naiyin Wang, Pervinder Sagoo, Qi Peng, Wafa Khamri, Chantelle Gomes, Steven H. Sacks, Giovanna Lombardi, Wuding Zhou
MOLECULAR IMMUNOLOGY
(2011)
Article
Multidisciplinary Sciences
Richard Tavare, Pervinder Sagoo, Gopal Varama, Yakup Tanriver, Alice Warely, Sandra S. Diebold, Richard Southworth, Tobias Schaeffter, Robert I. Lechler, Reza Razavi, Giovanna Lombardi, Gregory E. D. Mullen
Article
Cell Biology
Pervinder Sagoo, Niwa Ali, Garima Garg, Frank O. Nestle, Robert I. Lechler, Giovanna Lombardi
SCIENCE TRANSLATIONAL MEDICINE
(2011)
Article
Cell & Tissue Engineering
Sanja Bojic, Dean Hallam, Nuno Alcada, Ali Ghareeb, Rachel Queen, Sagoo Pervinder, Harley Buck, Aya Amitai Lange, Gustavo Figueiredo, Paul Rooney, Miodrag Stojkovic, Alex Shortt, Francisco C. Figueiredo, Majlinda Lako
Article
Immunology
Cees van Kooten, Giovanna Lombardi, Kyra A. Gelderman, Pervinder Sagoo, Matthew Buckland, Robert Lechler, Maria Cristina Cuturi
Review
Immunology
Pervinder Sagoo, Giovanna Lombardi, Robert I. Lechler
FRONTIERS IN IMMUNOLOGY
(2012)
Article
Urology & Nephrology
Esperanza Perucha, Irene Rebollo-Mesa, Pervinder Sagoo, Maria P. Hernandez-Fuentes
KIDNEY INTERNATIONAL SUPPLEMENTS
(2011)