Review
Immunology
Eoin N. Blythe, Lynne C. Weaver, Arthur Brown, Gregory A. Dekaban
Summary: CD11d/CD18 is a recently discovered and poorly understood β2 integrin, playing a crucial role in localizing white blood cells to inflammation sites. Although its adhesive mechanisms and signaling pathways have been investigated, further research is needed to fully understand its functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jane Arciszewski, Karine Auclair
Summary: Mechanoenzymology is an emerging field that utilizes mechanical mixing to sustain enzymatic reactions in low-solvent or solvent-free mixtures. It can be applied to the synthesis or depolymerization of polymeric materials, offering various advantages.
Article
Biochemistry & Molecular Biology
Angie de la Cruz, Aubrey Hargrave, Sri Magadi, Justin A. Courson, Paul T. Landry, Wanyu Zhang, Fong W. Lam, Monica A. Bray, C. Wayne Smith, Alan R. Burns, Rolando E. Rumbaut
Summary: Platelet extravasation during inflammation is influenced by CD18, PMNs, and mast cell degranulation. Injured corneas with deficiencies in CD18 or mast cells show reduced platelet and RBC extravasation, highlighting the importance of these factors in the process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Sofie Vandendriessche, Seppe Cambier, Paul Proost, Pedro E. Marques
Summary: The complement system plays a crucial role in controlling microorganisms and removing dead cells, while also stimulating adaptive immune responses and tissue regeneration. Complement receptors on leukocytes and parenchymal cells are essential for recognizing complement-derived molecules and promoting immune responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jingming Zhang, Chengkou Liu, Yaqi Qiao, Minghui Wei, Wenjing Guan, Ziren Mao, Hong Qin, Zheng Fang, Kai Guo
Summary: A new methodology was developed to obtain unusual cyclization products from regular migration substrates. Instead of the usual migration to di-functionalization products of olefins, highly complex and structurally important spirocyclic compounds were produced through radical addition, intramolecular cyclization, and ring opening. The proposed mechanism was supported by a series of mechanistic studies, including radical trapping, radical clock, verification experiments of intermediates, isotope labeling, and KIE experiments.
Article
Pharmacology & Pharmacy
Alexander Hamers, Christopher P. Primus, Charlotte Whitear, Nitin Ajit Kumar, Michael Masucci, Shanik A. Montalvo Moreira, Krishnaraj Rathod, Jianmin Chen, Kristen Bubb, Romain Colas, Rayomand S. Khambata, Jesmond Dalli, Amrita Ahluwalia
Summary: This study demonstrates that endogenously generated 20-HETE activates TRPV1, leading to C-fiber activation and edema formation, which may be a potential pathway for therapeutic intervention in conditions characterized by neurogenic inflammation, such as certain skin diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Rouven Schoppmeyer, Abraham C. van Steen, Lanette Kempers, Anne L. Timmerman, Martijn A. Nolte, Pleun Hombrink, Jaap D. van Buul
Summary: This study investigates how cytotoxic T lymphocytes (CTLs) efficiently leave the circulation to target cancer cells or contribute to inflammation by crossing the endothelium. The researchers found that human central memory CTLs predominantly cross the endothelium in a paracellular fashion, while effector and effector memory CTLs preferentially cross in a transcellular fashion. The study also reveals the mechanism of CTL-endothelium interaction and the involvement of ICAM-1 and CX3CL1:CX3CR1 in transcellular migration.
Review
Cell Biology
Ana-Maria Lennon-Dumenil, Helene D. Moreau
Summary: Cell migration plays a crucial role in physiological functions, being guided by both chemical and physical cues. Besides chemokines, the physical properties of tissues like hydraulic resistance also influence cell migration and may be involved in immune and cancer cell processes.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Rodrigo J. Gonzalez, Ulrich H. von Andrian
Summary: The interaction between GPR35 receptor and 5-HIAA serotonin metabolite promotes the recruitment of neutrophils from blood into inflamed tissues, which is significant for inflammation and anti-microbial host defense.
Review
Cell Biology
Maneesha Kunnathattil, Pedapudi Rahul, Tom Skaria
Summary: This article critically reviews the potential of soluble vascular endothelial glycocalyx proteoglycans in modulating pathological inflammatory responses. It discusses the beneficial anti-inflammatory effects of syndecan-1, syndecan-3, and biglycan, as well as the proinflammatory effects of versikine and decorin. It suggests that targeting these soluble proteoglycans may be a potential therapeutic strategy to suppress overstimulated cytokine and leukocyte responses in inflammatory diseases.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Virology
Wallace Pitanga Bezerra, Amanda Costa Ayres Salmeron, Anna Claudia Calvielli Castelo Branco, Ingryd Camara Morais, Valeria Soraya de Farias Sales, Paula Renata Lima Machado, Janeusa Trindade Souto, Joselio Maria Galvao de Araujo, Paulo Marcos da Matta Guedes, Maria Notomi Sato, Manuela Sales Lima Nascimento
Summary: This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to Congenital Zika Syndrome (CZS). The results showed decreased levels of CCL2 and CXCL8, and increased levels of IgE in the serum of these children, along with a high prevalence of allergies. These findings suggest a persistent systemic inflammation in children with microcephaly due to CZS, and possible impairment in leukocyte migration caused by low production of CCL2 and CXCL8.
Article
Multidisciplinary Sciences
Xiangdi Mao, Sainan Min, Qihua He, Xin Cong
Summary: Saliva plays a crucial role in oral and overall health, and alterations in the endothelial barrier function are related to salivary gland secretory disorders. This protocol describes an in vivo detection method to evaluate the function of endothelial tight junctions in mouse submandibular glands.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Multidisciplinary Sciences
Alessandra Marrella, Arianna Fedi, Gabriele Varani, Ivan Vaccari, Marco Fato, Giuseppe Firpo, Patrizia Guida, Nicola Aceto, Silvia Scaglione
Summary: This study developed a new multichannel microfluidic device to simulate different blood flow shear stresses and analyze their correlation with CTC cluster behavior. The results demonstrated that higher values of WSS decrease the viability of single CTCs and lead to the disaggregation of CTC clusters.
Article
Immunology
Anna Barkaway, Loic Rolas, Regis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods, Natalia Reglero-Real, Monja Stein, Laura Vazquez-Martinez, Tamara Girbl, Robin N. Poston, Matthew Golding, Rebecca S. Saleeb, Aude Thiriot, Ulrich H. von Andrian, Johan Duchene, Mathieu-Benoit Voisin, Cleo L. Bishop, David Voehringer, Axel Roers, Antal Rot, Tim Laemmermann, Sussan Nourshargh
Summary: Aging is associated with dysregulated immune functions, affecting neutrophil diapedesis. In aged mice, neutrophils exhibit reverse transendothelial migration, causing remote organ damage.
Review
Pharmacology & Pharmacy
Huayu Wu, Weishuo Li, Meixi Hao, Yujiao Wang, Lingjing Xue, Caoyun Ju, Can Zhang
Summary: This article reviews the concept and applications of leukocytes as drug delivery vehicles. Leukocytes have the ability to cross the vessel wall and crawl through tissue interstitium, making them a promising delivery carrier.
ADVANCED DRUG DELIVERY REVIEWS
(2022)