Article
Multidisciplinary Sciences
Zhigang Chen, Rong Fan, Jie Liang, Zexiu Xiao, Junlong Dang, Jun Zhao, Ruihui Weng, Cansheng Zhu, Song Guo Zheng, Ying Jiang
Summary: This study found that NFIL3 deficiency could alleviate MOG35-55-induced EAE by regulating different immune cell subsets, especially the crosstalk between CD4+ T cells and CD11c+ dendritic cells.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Summary: Research on multiple sclerosis and autoimmune diseases has found that targeting deoxycytidine kinase (dCK) can limit the progression of symptoms, and dCK activity is essential for activation-induced proliferation in specific lymphocytes.
Article
Immunology
Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Laijun Lai
Summary: ERMAP has been identified as a novel T cell inhibitory molecule, with its fusion protein inhibiting T cell functions and ameliorating autoimmune diseases in vitro. Additionally, anti-ERMAP antibody enhances macrophage phagocytosis of cancer cells and inhibits tumor growth in mice, likely through blocking ERMAP's inhibitory effects on T cells and macrophages. Therapeutic targeting of the ERMAP inhibitory pathway may offer a novel strategy for treating patients with autoimmune disease or cancer.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gil-Ran Kim, Won-Ju Kim, Sangho Lim, Hong-Gyun Lee, Ja-Hyun Koo, Kyung-Ho Nam, Sung-Min Kim, Sung-Dong Park, Je-Min Choi
Summary: The study demonstrates that a novel chimeric CTLA-4 signaling peptide can induce regulatory T cells effectively in vivo, showing potential therapeutic effects for autoimmune diseases such as multiple sclerosis.
Article
Immunology
Ping Shen, Madlen Rother, Ulrik Stervbo, Vicky Lampropoulou, Elisabeth Calderon-Gomez, Toralf Roch, Ellen Hilgenberg, Steffi Ries, Anja A. Kuehl, Luc Jouneau, Pierre Boudinot, Simon Fillatreau
Summary: This study demonstrates the critical role of neutrophils in the regulation of antigen-specific CD4(+) T cell expansion in lymph nodes, and the counter-regulatory role of TLR signaling in this process.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
David W. Scott
Summary: The use of CAR transduced T cells and engineered Tregs with specific receptors show great promise in cancer immunotherapy. Methods involving retroviral transduction of specific T-cell receptors, scFv, or antigens for various diseases models are discussed for their potential clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Samuel J. Duesman, Sandra Ortega-Francisco, Roxana Olguin-Alor, Naray A. Acevedo-Dominguez, Christine M. Sestero, Rajeshwari Chellappan, Patrizia De Sarno, Nabiha Yusuf, Adrian Salgado-Lopez, Marisol Segundo-Liberato, Selina Montes de Oca-Lagunas, Chander Raman, Gloria Soldevila
Summary: The transforming growth factor receptor III (T beta RIII) is a co-receptor that regulates T cell development in the immune system and controls the pathogenicity of autoreactive T cells in neuroinflammation. T beta RIII null mice showed increased severity of autoimmune central nervous neuroinflammatory disease and expanded numbers of IFN gamma(+) CD4(+) T cells. This suggests that T beta RIII may be involved in regulating the conversion of encephalitogenic Th17 to Th1 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Meilang Xue, Haiyan Lin, Hai Po Helena Liang, Lara Bereza-Malcolm, Tom Lynch, Premarani Sinnathurai, Hartmut Weiler, Christopher Jackson, Lyn March
Summary: This study found that the deficiency of EPCR can ameliorate the onset and development of CIA by inhibiting the activation and migration of pathogenic Th cells and DCs. Therefore, targeting EPCR may constitute a novel strategy for future RA treatment.
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Aaron H. S. Heng, Caleb W. Han, Caitlin Abbott, Shaun R. McColl, Iain Comerford
Summary: Pro-inflammatory CD4(+) T helper cells play a crucial role in autoimmune diseases. Recent research has revealed the heterogeneity of chemokine receptors expressed by these cells, which are responsible for recruiting different subsets of pro-inflammatory Th cells in autoimmune inflammation. Understanding these receptors may lead to potential therapeutic targets for intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xuejun Zhang, Chuan Yu, Jin-Qing Liu, Xue-Feng Bai
Summary: CD24 is a cell surface glycoprotein that functions as a co-stimulatory molecule. However, its role on antigen presenting cells during T cell responses is not well understood. This study shows that CD24 deficiency in hosts leads to inefficient expansion and accelerated cell death of adoptively transferred CD4(+) T cells in lymph nodes, resulting in inadequate T cell priming. Transgenic expression of CD24 on dendritic cells restores T cell accumulation and survival in draining lymph nodes, suggesting a novel role of CD24 in optimal T cell priming.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Huan-Li Yang, Xiao-Wu Shi
Summary: Silybin effectively alleviated experimental autoimmune encephalomyelitis by inhibiting dendritic cell activation and Th17 cell differentiation, demonstrating potential for developing a novel therapeutic agent for the treatment of multiple sclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Noemi Anna Nagy, Fernando Lozano Vigario, Rinske Sparrius, Toni M. M. van Capel, Ronald W. van Ree, Sander Tas, I. Jolanda M. de Vries, Teunis B. H. Geijtenbeek, Bram C. Slutter, Esther de Jong
Summary: Nanomedicine offers a promising platform for manipulating dendritic cells (DCs) and the adaptive immune response. Liposomal vitamin D3 can induce the development of regulatory CD4+ T cells and inhibit the proliferation of memory T cells. It can also suppress the development of Th1 and Th17 cells and stimulate the migration of CD14+ skin DCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
David M. Chascsa, Elise M. N. Ferre, Yannis Hadjiyannis, Hawwa Alao, Mukil Natarajan, Mariam Quinones, David E. Kleiner, Thomas L. Simcox, Ehsan Chitsaz, Stacey R. Rose, Asa Hallgren, Olle Kampe, Jamie Marko, Rabab O. Ali, Sungyoung Auh, Christopher Koh, Yasmine Belkaid, Michail S. Lionakis, Theo Heller
Summary: The study found that APAH is more common than previously described, may present early before classic APECED manifestations, and most often manifests with milder, treatment-responsive disease. Several APECED-associated autoantibodies, but not standard AIH-associated biomarkers, correlate with APAH.
Article
Endocrinology & Metabolism
Sigridur Bjornsdottir, Bart Clarke, Outi Makitie, Anna Sandstrom, Eleonor Tiblad, Tim Spelman, Olle Kampe
Summary: The study found that pregnant women with chronic hypoPT are more likely to have accompanying diabetes and chronic kidney disease compared to the control group, and are at increased risk of induction of labor and slightly lower infant birth weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Jun-Hong Ch'ng, Kirsten Moll, Katja Wyss, Ulf Hammar, Mikael Ryden, Olle Kampe, Anna Farnert, Mats Wahlgren
Summary: The study reveals an association between type 2 diabetes and parasite growth and rosetting, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes.
Article
Immunology
Hassan Abolhassani, Ahmad Vosughimotlagh, Takaki Asano, Nils Landegren, Bertrand Boisson, Samaneh Delavari, Paul Bastard, Maribel Aranda-Guillen, Yating Wang, Fanglei Zuo, Fabian Sardh, Harold Marcotte, Likun Du, Shen-Ying Zhang, Qian Zhang, Nima Rezaei, Olle Kampe, Jean-Laurent Casanova, Lennart Hammarstrom, Qiang Pan-Hammarstrom
Summary: This study identified a unique case of a patient with a preexisting inborn error of immunity (IEI) who developed critical COVID-19 pneumonia. Genetic analysis revealed homozygous deleterious mutations in the ATM gene and a hemizygous deleterious mutation in the TLR7 gene, underlying Ataxia-Telangiectasia (A-T) and critical COVID-19 in this patient. Among other A-T patients evaluated, SARS-CoV-2 infection resulted in mild symptoms or asymptomatic cases, highlighting the importance of genetic factors in COVID-19 severity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Hassan Abolhassani, Nils Landegren, Paul Bastard, Marie Materna, Mohammadreza Modaresi, Likun Du, Maribel Aranda-Guillen, Fabian Sardh, Fanglei Zuo, Peng Zhang, Harold Marcotte, Nico Marr, Taushif Khan, Manar Ata, Fatima Al-Ali, Remi Pescarmona, Alexandre Belot, Vivien Beziat, Qian Zhang, Jean-Laurent Casanova, Olle Kampe, Shen-Ying Zhang, Lennart Hammarstrom, Qiang Pan-Hammarstrom
Summary: This study identified a rare case with concomitant critical COVID-19 pneumonia and MIS-C, and found a genetic variant associated with IFNAR1 deficiency through whole exome sequencing. It highlights the importance of type I interferon immunity and suggests that inherited or acquired dysregulation of this immune response may contribute to MIS-C.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jakob Skov, Ralf Kuja-Halkola, Patrik K. E. Magnusson, Soffia Gudbjornsdottir, Olle Kampe, Sophie Bensing
Summary: Type 1 diabetes and Hashimoto's thyroiditis often coexist in individuals and families, with shared genetic and environmental factors contributing to their etiology. Twins have a higher risk of developing both diseases compared to the general population. Genetic factors account for a portion of the overlap, while unique environmental factors also play a significant role.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Annelies van't Westeinde, Sara Strom, Tatja Hirvikoski, Per Dahlqvist, Jeanette Wahlberg, Anton Gezelius, Olle Kampe, Sophie Bensing, Svetlana Lajic
Summary: The study found that young adult female patients with autoimmune Addison's disease (AAD) experience problems with executive functions in daily life, despite performing normally in cognitive tests. Coping with mental fatigue and optimizing pharmacotherapy may be important factors to provide timely support for patients.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Rheumatology
Christian Lundtoft, Pascal Pucholt, Myriam Martin, Matteo Bianchi, Emeli Lundstrom, Maija-Leena Eloranta, Johanna K. Sandling, Christopher Sjowall, Andreas Jonsen, Iva Gunnarsson, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Dag Leonard, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Antonella Notarnicola, Helena Andersson, Oyvind Molberg, Louise Pyndt Diederichsen, Jonas Almlof, Ann-Christine Syvanen, Sergey Kozyrev, Kerstin Lindblad-Toh, Bo Nilsson, Anna M. Blom, Ingrid E. Lundberg, Gunnel Nordmark, Lina Marcela Diaz-Gallo, Elisabet Svenungsson, Lars Ronnblom
Summary: Copy number variation of C4A is associated with the autoimmune repertoire in systemic autoimmune diseases, with a low C4A copy number strongly linked to the presence of autoantibodies. These findings have implications for understanding the mechanisms of autoimmune diseases and patient stratification based on genetic profiles.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Oskar Swartling, Marie Evans, Tim Spelman, Wafa Kamal, Olle Kampe, Michael Mannstadt, Ylva Trolle Lagerros, Sigridur Bjornsdottir
Summary: Patients with chronic hypoparathyroidism treated with activated vitamin D and calcium supplementation may have a higher risk of kidney complications. This population-based cohort study found that patients with chronic hypoparathyroidism were at increased risk for developing chronic kidney disease, urolithiasis, and hospitalization compared to controls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Allergy
Hassan Abolhassani, Samaneh Delavari, Nils Landegren, Sima Shokri, Paul Bastard, Likun Du, Fanglei Zuo, Reza Hajebi, Farhad Abolnezhadian, Sara Iranparast, Mohammadreza Modaresi, Ahmad Vosughimotlagh, Fereshte Salami, Maribel Aranda-Guillen, Aurelie Cobat, Harold Marcotte, Shen-Ying Zhang, Qian Zhang, Nima Rezaei, Jean-Laurent Casanova, Olle Kampe, Lennart Hammarstrom, Qiang Pan-Hammarstrom
Summary: In most children with preexisting inborn errors of immunity (IEI), genetic causes that affect immune system function were identified. The severity of COVID-19 in these children was high, with a significant mortality rate. Therefore, it is crucial to develop strategies for the prevention and treatment of COVID-19 in children with IEI.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Emilie W. Borgstrom, Marie Edvinsson, Lucia P. Perez, Anna C. Norlin, Sara L. Enoksson, Susanne Hansen, Anders Fasth, Vanda Friman, Olle Kampe, Robert Mansson, Hernando Y. Estupinan, Qing Wang, Tan Ziyang, Tadepally Lakshmikanth, Carl Inge E. Smith, Petter Brodin, Peter Bergman
Summary: This study investigated the clinical effects and biomarker alterations in three patients with chronic mucocutaneous candidiasis (CMC) caused by gain-of-function mutations in the STAT1 gene during treatment with Janus kinase (JAK) inhibitors. The results showed that JAK inhibitors improved clinical symptoms of CMC, but also caused side effects. The treatment had a sustained effect on the populations of neutrophils, T cells, B cells, and NK cells. Additionally, the treatment enhanced cellular reactivity against Candida albicans and altered plasma biomarkers.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Biology
Sara E. Vazquez, Sabrina A. Mann, Aaron Bodansky, Andrew F. Kung, Zoe Quandt, Elise M. N. Ferre, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y. Chan, Veronica M. Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R. Wilson, Olle Kaempe, Kerry Dobbs, Ottavia M. Delmonte, Rosa Bacchetta, Luigi D. Notarangelo, Jane C. Burns, Jean-Laurent Casanova, Michail S. Lionakis, Troy R. Torgerson, Mark S. Anderson, Joseph L. DeRisi
Summary: Phage immunoprecipitation sequencing (PhIP-seq) is a unbiased method for discovering autoantibodies and studying immune dysregulation in various diseases. This study developed and validated a high throughput extension of PhIP-seq, which can be applied to autoimmune and inflammatory diseases, providing prediction of disease status and detection of autoantigens.
Review
Endocrinology & Metabolism
Johan G. Beun, Pia Burman, Olle Kampe, Eystein S. Husebye, Stephanie Hahner, Jette Kristensen, Alida Noordzij, Per Dahlqvist
Summary: Adrenal insufficiency is a life-threatening condition that requires long-term glucocorticoid replacement therapy and stress adaptation to prevent adrenal crises. Education on handling an adrenal crisis is crucial for improving patients' self-sustainability. All patients should carry the European Emergency Card.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Sara Oster, Daniela Esposito, Maribel Aranda-Guillen, Anna-Karin Akerman, Jeanette Wahlberg, Eystein Sverre Husebye, Olle Kampe, Ileana Ruxandra Botusan, Per Dahlqvist, Ragnhildur Bergthorsdottir, Sophie Bensing
Summary: This study aimed to investigate the incidence of COVID-19 in patients with autoimmune Addison's disease (AAD) in Sweden during the COVID-19 pandemic. The results showed that although approximately one-fifth of the patients contracted COVID-19, only a small percentage required hospital care. Despite limited communication with healthcare, the majority of patients followed recommended sick rules.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Immunology
Thea Sjogren, Eirik Bratland, Ellen C. Royrvik, Marianne Aa Grytaas, Andreas Benneche, Per M. Knappskog, Olle Kampe, Bergithe E. Oftedal, Eystein S. Husebye, Anette S. B. Wolff
Summary: Screening for cytokine autoantibodies can efficiently identify patients with previously unknown monogenic and possible oligogenic causes of autoimmune and immune deficiency diseases, providing crucial information for personalized treatment and follow-up.
JOURNAL OF AUTOIMMUNITY
(2022)