Article
Biochemistry & Molecular Biology
Janina Sponsel, Yubing Guo, Lutfir Hamzam, Alice C. Lavanant, Annia Perez-Riveron, Emma Partiot, Quentin Muller, Julien Rottura, Raphael Gaudin, Dirk Hauck, Alexander Titz, Vincent Flacher, Winfried Roemer, Christopher G. Mueller
Summary: Pseudomonas aeruginosa produces a virulence factor, LecB, that binds to endothelial cells and disrupts leukocyte passage, impairing immune response. The lecturer also impacts dendritic cell migration and T cell activation. Inhibiting LecB can restore immune response, highlighting its importance in combating P. aeruginosa infection.
Article
Immunology
Sina Tadayon, Johannes Dunkel, Akira Takeda, Dominik Eichin, Reetta Virtakoivu, Kati Elima, Sirpa Jalkanen, Maija Hollmen
Summary: Clever-1, a molecule expressed on certain macrophages and lymphatic endothelial cells, plays a role in regulating DC trafficking and immune responses. Despite hindering DC entry into lymphatics, Clever-1 knockout mice showed increased MHC II expression on DCs and less tolerogenic LEC phenotype in lymph nodes, leading to stronger antigen-specific immune responses. This suggests that Clever-1 facilitates immunosuppressive interactions with migrating DCs, modulating immune responses in the draining lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Di Peng, Koji Ando, Melina Hussmann, Marleen Gloger, Renae Skoczylas, Naoki Mochizuki, Christer Betsholtz, Shigetomo Fukuhara, Stefan Schulte-Merker, Nathan D. Lawson, Katarzyna Koltowska
Summary: In zebrafish, arterial mural cells have been identified as a crucial source of signals that guide the migration and survival of lymphatic endothelial cells (LECs), promoting the establishment of the lymphatic vascular network. The cooperative function of chemokine and growth factor signaling, particularly through the VEGFC-VEGFR3 pathway, plays a key role in LEC migration.
Article
Biochemistry & Molecular Biology
Susanna Fiorelli, Andrea Anesi, Benedetta Porro, Nicola Cosentino, Jose P. Werba, Alessandro Di Minno, Chiara Maria Manega, Simone Barbieri, Gualtiero Colombo, Giancarlo Marenzi, Viviana Cavalca, Elena Tremoli, Sonia Eligini
Summary: The study focused on investigating the migration capacity of monocytes isolated from patients with acute myocardial infarction (AMI) at hospital presentation and its correlation with cellular lipid profile. It was found that AMI patients' monocytes exhibited increased migration and a distinct lipidomic profile compared to controls, with lactosylceramide levels positively correlating with migration and lactosylceramide synthase inhibition significantly reducing monocyte migration induced by fetal bovine serum. These results suggest a potential mechanism involving lactosylceramide in the development of atherothrombosis and AMI.
Article
Biochemistry & Molecular Biology
Maria Jesus Vera, Francisco Guajardo, Felix A. Urra, Nicolas Tobar, Jorge Martinez
Summary: The influence of an inflammatory microenvironment on tumorigenesis, particularly in relation to breast cancer progression, is well-established. Under conditions of obesity, adipose tissue endocrine function plays a significant role in the production of local and systemic inflammatory mediators. However, the mechanisms by which these mediators stimulate tumorigenesis and recruit inflammatory cells remain unclear.
Editorial Material
Immunology
Remi Hatinguais, Gordon D. Brown
Summary: After internalizing an actin-bearing ligand, the C-type lectin receptor DNGR-1 promotes phagosome rupture, allowing antigens to enter the cytosol for processing through the MHC-I pathway.
Article
Immunology
Vyoma K. Patel, Helen Williams, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: The study found that dyslipidemia is associated with an increased potential of all monocyte subsets to extravasate, using a wider repertoire of recruitment markers. While monocyte subsets differed significantly in their expression of recruitment markers, considerable inter-participant differences played a larger role in influencing this difference.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Vanessa Chilunda, Jessica Weiselberg, Samuel Martinez-Meza, Lwidiko E. Mhamilawa, Laura Cheney, Joan W. Berman
Summary: HIV-associated neurocognitive impairment (HIV-NCI) persists in a significant percentage of people with HIV despite effective antiretroviral therapy. Using RNA-sequencing, this study found that methamphetamine increases the infiltration of mature monocytes into the central nervous system, leading to dysregulated inflammatory responses and viral reservoir establishment and persistence, both of which contribute to neuronal damage. The study highlights potential molecules that may be targeted for therapy to limit the effects of meth on HIV neuropathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chi Ho Wai, Jessica Jin, Marek Cyrklaff, Christel Genoud, Charlotta Funaya, Julia Sattler, Aleksandra Maceski, Stephanie Meier, Sabine Heiland, Michael Lanzer, Friedrich Frischknecht, Jens Kuhle, Martin Bendszus, Angelika Hoffmann
Summary: This study assessed whether serum levels of neurofilament light chain (NfL) can indicate the severity of cerebral malaria. The results showed that although NfL plasma levels were elevated during the disease, they were not able to reliably predict the final outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Christelle Damon-Soubeyrand, Antonino Bongiovanni, Areski Chorfa, Chantal Goubely, Nelly Pirot, Luc Pardanaud, Laurence Piboin-Fragner, Caroline Vachias, Stephanie Bravard, Rachel Guiton, Jean-Leon Thomas, Fabrice Saez, Ayhan Kocer, Meryem Tardivel, Joel R. Drevet, Joelle Henry-Berger
Summary: The epididymis plays a crucial role in male fertility and has both secretory and immune functions. However, the organization of blood and lymphatic networks in the epididymis is still largely unknown.
Article
Biochemistry & Molecular Biology
Jia Guo, Zeyu Xu, Rachel C. Gunderson, Baohui Xu, Sara A. Michie
Summary: In this study, the researchers found that ICAM-1 is expressed on the sinus endothelia of lymph nodes, but not on the lymphatic vessels of peripheral tissues. Memory CD4(+) T cells migrated to lymph nodes from peripheral tissues more efficiently than from blood vessels. ICAM-1 deficiency significantly inhibited the migration of lymphocytes from peripheral tissues into lymph nodes, and the absence of ICAM-1 or LFA-1 reduced the number of memory T cells in lymph nodes.
Review
Physiology
Natalie R. Harris, Laszlo Balint, Danielle M. Dy, Natalie R. Nielsen, Hernan G. Mendez, Amir Aghajanian, Kathleen M. Caron
Summary: This review investigates the complex relationship between cardiac lymphatics, myocardial edema, and cardiac disease. It covers the revised paradigm of microvascular forces and fluid movement, as well as the preclinical tools and animal models used to study myocardial edema and cardiac disease. Clinical studies and recent animal studies on the role of cardiac lymphatics in cardiovascular disease models are analyzed. The outstanding questions regarding the roles of cardiac lymphatics in health and disease are highlighted.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Jost B. Jonas, Rahul A. Jonas, Shefali B. Jonas, Songhomitra Panda-Jonas
Summary: This study found that the size of the ciliary body stroma (CBS) is significantly smaller in eyes with a chronically closed endothelialized anterior chamber angle than in eyes with open angles. The angle tightening in eyes with angle-closure may restrict the access of aqueous humor to the ciliary body and reduce the outflow pathway.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Michelle G. Pedler, J. Mark Petrash, Prem S. Subramanian
Summary: Brain cerebrospinal fluid outflow can be increased by nasal inhalation of ophthalmic prostaglandin F2alpha analogs, with the greatest effect observed with latanoprost. Further studies are required to assess the efficacy of these agents in reducing intracranial pressure in both short and long-term applications.
Review
Immunology
Woojong Lee, M. Suresh
Summary: This review focuses on recent insights into DC cross-presentation and the impact of clinically relevant vaccine adjuvants on DC cross-presentation efficiency. Understanding these mechanisms is crucial for the rational design of vaccines that elicit balanced antibody- and T cell-based immunity against infectious diseases and cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jose M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, Maria Isabel Cuartero, Maria Casanova-Acebes, Linnea A. Weiss, Hector Huerga-Encabo, Carlos Silvestre-Roig, Jan Rossaint, Itziar Cossio, Ana V. Lechuga-Vieco, Jaime Garcia-Prieto, Monica Gomez-Parrizas, Juan A. Quintana, Ivan Ballesteros, Sandra Martin-Salamanca, Alejandra Aroca-Crevillen, Shu Zhen Chong, Maximilien Evrard, Karl Balabanian, Jorge Lopez, Kiril Bidzhekov, Frangoise Bachelerie, Francisco Abad-Santos, Cecilia Munoz-Calleja, Alexander Zarbock, Oliver Soehnlein, Christian Weber, Lai Guan Ng, Cristina Lopez-Rodriguez, David Sancho, Maria A. Moro, Borja Ibanez, Andres Hidalgo
Editorial Material
Immunology
Carlos del Fresno, David Sancho
TRENDS IN IMMUNOLOGY
(2019)
Review
Immunology
Carlos del Fresno, Francisco J. Cueto, David Sancho
FRONTIERS IN IMMUNOLOGY
(2019)
Correction
Immunology
Jose M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, Maria Isabel Cuartero, Maria Casanova-Acebes, Linnea A. Weiss, Hector Huerga-Encabo, Carlos Silvestre-Roig, Jan Rossaint, Itziar Cossio, Ana V. Lechuga-Vieco, Jaime Garcia-Prieto, Monica Gomez-Parrizas, Juan A. Quintana, Ivan Ballesteros, Sandra Martin-Salamanca, Alejandra Aroca-Crevillen, Shu Zhen Chong, Maximilien Evrard, Karl Balabanian, Jorge Lopez, Kiril Bidzhekov, Francoise Bachelerie, Francisco Abad-Santos, Cecilia Munoz-Calleja, Alexander Zarbock, Oliver Soehnlein, Christian Weber, Lai Guan Ng, Cristina Lopez-Rodriguez, David Sancho, Maria A. Moro, Borja Ibanez, Andres Hidalgo
Editorial Material
Immunology
Carlos del Fresno, David Sancho
Review
Immunology
Francisco J. Cueto, Carlos del Fresno, David Sancho
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Mattia Gallizioli, Francesc Miro-Mur, Amaia Otxoa-de-Amezaga, Roger Cugota, Angelica Salas-Perdomo, Carles Justicia, Vanessa H. Brait, Francisca Ruiz-Jaen, Maria Arbaizar-Rovirosa, Jordi Pedragosa, Ester Bonfill-Teixidor, Mathias Gelderblom, Tim Magnus, Eva Cano, Carlos del Fresno, David Sancho, Anna M. Planas
Review
Immunology
Carlos del Fresno, David Sancho
Summary: Myeloid cells are an integral part of the immune system and play a crucial role in detecting tissue damage and initiating inflammatory responses to aid in resolution of the damage. They detect ligands released by dead cells through specific receptors, leading to diverse responses.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Oncology
Francisco J. Cueto, Carlos Del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernandez-Garcia, Alfonso R. Sanchez-Paulete, Michel Enamorado, Christian P. Bromley, Manuel J. Gomez, Ruth Conde-Garrosa, Santos Manes, Santiago Zelenay, Ignacio Melero, Salvador Iborra, Matthew F. Krummel, David Sancho
Summary: This study reveals that DNGR-1 restricts the accumulation of tumor-infiltrating cDC1s induced by Flt3L, and suggests that blocking DNGR-1 may enhance antitumor immunity in the context of high Flt3L expression in tumor therapy settings.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Karla Montalban-Hernandez, Ramon Cantero-Cid, Roberto Lozano-Rodriguez, Alejandro Pascual-Iglesias, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria Cristina Bonel Perez, Jenny Guevara, Cristobal Marcano, Cristina Barragan, Jaime Valentin, Carlos del Fresno, Luis Augusto Aguirre, Eduardo Lopez Collazo
Summary: Among colorectal cancer patients, the level of soluble SIGLEC5 may serve as a potential prognostic marker and predictor of patient outcomes.
Article
Biochemistry & Molecular Biology
Karla Montalban-Hernandez, Jose Carlos Casalvilla-Duenas, Patricia Cruz-Castellanos, Laura Gutierrez-Sainz, Roberto Lozano-Rodriguez, Jose Avendano-Ortiz, Carlos del Fresno, Javier de Castro-Carpeno, Eduardo Lopez-Collazo
Summary: The study demonstrates that the pre-operative sSIGLEC5 + sLAG3 score is a robust predictor of relapse in LC patients.
Article
Oncology
Eduardo Moreo, Santiago Uranga, Ana Pico, Ana Belen Gomez, Denise Nardelli-Haefliger, Carlos del Fresno, Ingrid Murillo, Eugenia Puentes, Esteban Rodriguez, Mar Vales-Gomez, Julian Pardo, David Sancho, Carlos Martin, Nacho Aguilo
Summary: By comparing the antitumoral efficacy of BCG and MTBVAC in a mouse model, this study found that MTBVAC can enhance bladder colonization by expressing specific absent proteins and stimulate cytotoxic responses to improve immune response against tumor antigens. Furthermore, intravesical bacterial immunotherapy using MTBVAC can lead to complete eradication of bladder tumors, either as a monotherapy or in combination with immune checkpoint inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Karla Montalban-Hernandez, Ramon Cantero-Cid, Jose Carlos Casalvilla-Duenas, Jose Avendano-Ortiz, Elvira Marin, Roberto Lozano-Rodriguez, Veronica Terron-Arcos, Marina Vicario-Bravo, Cristobal Marcano, Jorge Saavedra-Ambrosy, Julia Prado-Montero, Jaime Valentin, Rebeca Perez de Diego, Laura Cordoba, Elisa Pulido, Carlos del Fresno, Marta Duenas, Eduardo Lopez-Collazo
Summary: This study found that colorectal tumor hybrid cells (THCs) generated from in vitro co-culture of colorectal cancer stem cells and human monocytes showed enhanced migratory, proliferative, and immune evasion abilities compared to their parental cells. The number of THCs was found to be associated with prognosis and the spread of metastasis in colorectal cancer patients, indicating that the number of THCs could serve as a novel biomarker for metastasis prediction.
Article
Biochemistry & Molecular Biology
Karla Montalban-Hernandez, Cesar Casado-Sanchez, Jose Avendano-Ortiz, Jose Carlos Casalvilla-Duenas, Gloria C. Bonel-Perez, Julia Prado-Montero, Jaime Valentin-Quiroga, Roberto Lozano-Rodriguez, Veronica Terron-Arcos, Fatima Ruiz de la Bastida, Laura Cordoba, Fernando Laso-Garcia, Luke Diekhorst, Carlos del Fresno, Eduardo Lopez-Collazo
Summary: This study successfully generated a new hybrid cell population, named foam hybrid cell (FHC), through co-culture. The FHC exhibited enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. This finding is of great significance for stem cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Luis Augusto Aguirre, Karla Montalban-Hernandez, Jose Avendano-Ortiz, Elvira Marin, Roberto Lozano, Victor Toledano, Laura Sanchez-Maroto, Veronica Terron, Jaime Valentin, Elisa Pulido, Jose Carlos Casalvilla, Carolina Rubio, Luke Diekhorst, Fernando Laso-Garcia, Carlos del Fresno, Ana Collazo-Lorduy, Beatriz Jimenez-Munarriz, Paloma Gomez-Campelo, Emilio Llanos-Gonzalez, Maria Fernandez-Velasco, Carlos Rodriguez-Antolin, Rebeca Perez de Diego, Ramon Cantero-Cid, Enrique Hernadez-Jimenez, Enrique Alvarez, Rocio Rosas, Blanca Dies Lopez-Ayllon, Javier de Castro, Stefanie K. Wculek, Carolina Cubillos-Zapata, Inmaculada Ibanez de Caceres, Prudencio Diaz-Agero, Maria Gutierrez Fernandez, Maria Paz de Miguel, David Sancho, Leon Schulte, Rosario Perona, Cristobal Belda-Iniesta, Lisardo Bosca, Eduardo Lopez-Collazo