Article
Environmental Sciences
Gabriel K. Innes, Keeve E. Nachman, Alison G. Abraham, Joan A. Casey, Andrew N. Patton, Lance B. Price, Sara Y. Tartof, Meghan F. Davis
Summary: The study found that organically produced and processed meat samples had a significantly lower prevalence of MDRO compared to conventionally produced and processed samples, while meat from split processors had a lower prevalence of any contamination than samples from conventional processors. Additional studies are needed to confirm these findings and identify specific production and processing practices that may explain them.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Review
Cell Biology
Yejin Cao, Lin Dong, Ying He, Xuelian Hu, Yueru Hou, Yingjie Dong, Qiuli Yang, Yujing Bi, Guangwei Liu
Summary: Follicular T helper (Tfh) cells are crucial for B-cell differentiation and immune responses in humoral immunity and immune-related inflammatory diseases. Tfh cell differentiation involves self-directed and APCs-driven mechanisms, with Bcl-6 as a key transcription factor. Metabolic signaling also plays a critical role in Tfh cell differentiation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Lin Dong, Ying He, Yejin Cao, Yuexin Wang, Anna Jia, Yufei Wang, Qiuli Yang, Wanjie Li, Yujing Bi, Guangwei Liu
Summary: Follicular T helper (T-FH) cells are specialized T cells that support B cells and play a crucial role in humoral immunity. The functional differentiation of T-FH cells is tightly regulated by intricate mechanisms, including metabolic processes, and is closely associated with immune-related diseases.
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Review
Immunology
Hiroyuki Yoshitomi, Hideki Ueno
Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Bartolo Tamburini, Giusto Davide Badami, Leila Mohammadnezhad, Francesco Dieli, Nadia Caccamo
Summary: This article examines the heterogeneity of the memory T cell compartment, with a particular focus on the emerging role of CD8(+) T-RM and T-SCM cells in the immune metabolism or modulation in chronic infections or autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amania A. Sheikh, Joanna R. Groom
Summary: During viral infection, CD4(+) T cells differentiate into Th1 cells for inflammation and pathogen clearance, or Tfh cells for enhancing germinal center reactions. The lineage-defining transcription factors T-bet and Bcl6 play key roles in determining the fate of CD4(+) T cells toward Th1 or Tfh. Transcriptional networks guided by cytokine cues dynamically shape the fate and function of these cells during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Isabell Hollmann, Jan Berend Lingens, Bussarakam Chuppava, Volker Wilke, Amr Abd El-Wahab, Juhle Buch, Julia Hankel, Marwa F. E. Ahmed, Christian Visscher
Summary: This in vitro study investigates the effect of sodium butyrate on the growth of Salmonella enterica. The results suggest that sodium butyrate concentrations of 5-20 mM can suppress Salmonella growth within 6 hours, while concentrations of 40 and 80 mM can suppress growth within 24 hours.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Immunology
Julia Ritzau-Jost, Andreas Hutloff
Summary: This review discusses the optimization of Tfh cell generation and their interaction with B cells for therapeutic purposes. It also summarizes different T cell subsets, including Tph cells, and highlights the importance of T cell/B cell interaction in non-lymphoid tissues for the generation of protective antibodies.
Article
Chemistry, Analytical
Hiroki Ide, Wilfred Villariza Espulgar, Masato Saito, Taiki Aoshi, Shohei Koyama, Hyota Takamatsu, Eiichi Tamiya
Summary: The report discusses the development of an open-type PDMS microfluidic device to mimic the microenvironment of a lymph node for T cells to interact with APC. By measuring the Ca2+ flux of T cells interacting with APC, the threshold for specific T cell activation has been calculated. This new tool is expected to provide new insights and strategies for basic biology.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Immunology
Yao Huang, Xin Ba, Liang Han, Hui Wang, Weiji Lin, Zhe Chen, Shenghao Tu
Summary: The interactions between T cells and B cells play a crucial role in antibody responses and the development of autoimmune diseases. A recent discovery of a distinct subset of T cells called peripheral helper T (Tph) cells in synovial fluid has shed light on their potential roles in autoimmune diseases. Tph cells express high levels of CXCL13, which drive the formation of lymphoid aggregates and tertiary lymphoid structures, ultimately promoting the production of pathogenic autoantibodies. Further investigation of Tph cells may provide valuable insights into the pathogenesis of autoimmune diseases and identify novel therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Takehiro Ura, Masaki Takeuchi, Tatsukata Kawagoe, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada
Summary: This article discusses the importance and role of T cell-mediated immunity in vaccine development. It also introduces methods to enhance the immunogenicity of vaccines and the selection of viral vectors, as well as the advantages and applications of mRNA vaccines.
Review
Biochemistry & Molecular Biology
Gwenaelle Le Menn, Agnieszka Jablonska, Zhi Chen
Summary: Regulatory T (Treg) cells and Th17 cells play essential roles in immune homeostasis and infection. Dysregulation of the Th17/Treg cell balance contributes to the development of various diseases. Multiple factors influence the balance, including signaling, cytokines, metabolism, and epigenetic regulators.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Immunology
Lin Dong, Yejin Cao, Hui Yang, Yueru Hou, Ying He, Yufei Wang, Qiuli Yang, Yujing Bi, Guangwei Liu
Summary: This study reveals the critical role of MST1 in T-FH cell differentiation, germinal center formation, and antibody production. MST1 deficiency enhances T-FH cell differentiation and germinal center reaction. The mTOR and HIF1α signaling pathways play a role in this process, while upregulated Foxo3 expression is essential for MST1 deficiency-directed T-FH cell differentiation.
Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Article
Biology
Christopher Icke, Freya J. Hodges, Karthik Pullela, Samantha A. McKeand, Jack Alfred Bryant, Adam F. Cunningham, Jeff A. Cole, Ian R. Henderson
Summary: Protein acylation is essential for cellular functions and bacterial virulence, with lipoproteins being secreted and acylated through pathways like Sec and Lol. The Aat secretion system represents a novel composite system that showcases lipoproteins on the surface of bacterial cells.
Article
Microbiology
Jessica L. Rooke, Christopher Icke, Timothy J. Wells, Amanda E. Rossiter, Douglas F. Browning, Faye C. Morris, Jack C. Leo, Monika S. Schuetz, Ingo B. Autenrieth, Adam F. Cunningham, Dirk Linke, Ian R. Henderson
Summary: In this study, it was demonstrated that the efficient secretion of trimeric autotransporters requires BamA and BamD proteins, while BamB, C, E are not necessary. Unlike classical autotransporter secretion, neither trimeric autotransporter tested required TamA or B proteins for functional secretion.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Alisha Chetty, Matthew G. Darby, Pia M. Vornewald, Mara Martin-Alonso, Anna Filz, Manuel Ritter, Henry J. McSorley, Lindi Masson, Katherine Smith, Frank Brombacher, Matthew K. O'Shea, Adam F. Cunningham, Bernhard Ryffel, Menno J. Oudhoff, Benjamin G. Dewals, Laura E. Layland, William G. C. Horsnell
Summary: Research has shown that acute helminth infection induces a type 2 immune profile in the female genital tract, leading to increased epithelial ulceration and pathology during subsequent herpes simplex virus infection. This is mediated by an inflammatory circuit involving eosinophils, IL-33, and IL-5, which enhances the risk of vaginal epithelial necrosis and pathology.
CELL HOST & MICROBE
(2021)
Article
Immunology
Nadezhda Wall, Alexandra Godlee, Daniel Geh, Charlotte Jones, Sian Faustini, Ruth Harvey, Rebecca Penn, Dimitrios Chanouzas, Peter Nightingale, Matthew O'Shea, Alex Richter, Paul Moss, Adam Cunningham, Lorraine Harper
Summary: Patients with non-dialysis CKD can respond similarly to vaccines as healthy individuals in terms of immune response, despite displaying an immune signature independent of vaccine responsiveness. Prior immunization with PPV23 and CMV infection may influence CKD patients' responsiveness to vaccination.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Sian E. Faustini, Sian E. Jossi, Marisol Perez-Toledo, Adrian M. Shields, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Alex Cook, Carrie R. Willcox, Mahboob Salim, Margaret Goodall, Jennifer L. Heaney, Edith Marcial-Juarez, Gabriella L. Morley, Barbara Torlinska, David C. Wraith, Tonny V. Veenith, Stephen Harding, Stephen Jolles, Mark J. Ponsford, Tim Plant, Aarnoud Huissoon, Matthew K. O'Shea, Benjamin E. Willcox, Mark T. Drayson, Max Crispin, Adam F. Cunningham, Alex G. Richter
Summary: Detecting antibody responses during and after SARS-CoV-2 infection is crucial in determining the seroepidemiology of the virus and the potential role of antibody in disease. Developing sensitive and specific serological assays, as well as detecting antibody responses in both saliva and serum, can contribute to understanding virus exposure and immune responses after infection.
Letter
Allergy
Marisol Perez-Toledo, Sian E. Faustini, Sian E. Jossi, Adrian M. Shields, Edith Marcial-Juarez, Hari Krishnan Kanthimathinathan, Joel D. Allen, Yasunori Watanabe, Margaret Goodall, Benjamin E. Willcox, Carrie R. Willcox, Mahboob Salim, David C. Wraith, Tonny V. Veenith, Eleni Syrimi, Mark T. Drayson, Deepthi Jyothish, Eslam Al-Abadi, Ashish Chikermane, Steven B. Welch, Kavitha Masilamani, Scott Hackett, Max Crispin, Barnaby R. Scholefield, Adam F. Cunningham, Alex G. Richter
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Immunology
Alex G. Richter, Adrian M. Shields, Abid Karim, David Birch, Sian E. Faustini, Lora Steadman, Kerensa Ward, Timothy Plant, Gary Reynolds, Tonny Veenith, Adam F. Cunningham, Mark T. Drayson, David C. Wraith
Summary: The study revealed a higher frequency of autoantibodies associated with SARS-CoV-2 infection in COVID-19 patients, even detectable months post-infection. COVID-19 patients displayed a more restricted pattern of autoantibodies, including skin, skeletal muscle, and cardiac antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Ecology
Zhigang Yu, Yue Wang, Ian R. Henderson, Jianhua Guo
Summary: The study demonstrates that artificial sweeteners promote the horizontal transfer of antibiotic resistance genes among bacteria, increase plasmid persistence in transformants, and enhance cell envelope permeability by upregulating DNA uptake and translocation machinery. These findings highlight the need to evaluate the antibiotic-like side effects of environmental contaminants such as artificial sweeteners.
Article
Biochemistry & Molecular Biology
Himanshi Chawla, Sian E. Jossi, Sian E. Faustini, Firdaus Samsudin, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Edith Marcial-Juarez, Rachel E. Lamerton, Jason S. McLellan, Peter J. Bond, Alex G. Richter, Adam F. Cunningham, Max Crispin
Summary: The glycosylation of the expression-enhanced spike protein resembles that of an earlier version but with some differences; both HexaPro and 2P proteins are able to detect immune responses in infected individuals; variations in glycan processing do not impact serological assessments being performed globally.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Immunology
Claudia A. Freire, Rosa M. Silva, Rita C. Ruiz, Daniel C. Pimenta, Jack A. Bryant, Ian R. Henderson, Angela S. Barbosa, Waldir P. Elias
Summary: Escherichia coli uses strategies such as secretion of proteases to evade the host innate immune system. One member of the SPATE family, Sat, has been found to have proteolytic effects against complement proteins. This study demonstrates that Sat cleaves several proteins of the complement system and plays an important role in the establishment of bloodstream infections and sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Van Duc Dang, Elodie Mohr, Franziska Szelinski, Tuan Anh Le, Jacob Ritter, Timo Hinnenthal, Ana-Luisa Stefanski, Eva Schrezenmeier, Soeren Ocvirk, Christian Hipfl, Sebastian Hardt, Qingyu Cheng, Falk Hiepe, Max Loehning, Thomas Doerner, Andreia C. Lino
Summary: A large-scale protein screening identified twelve new molecules specifically expressed by murine ASCs, with stable expression of CD39, CD81, CD130, and CD326 offering improved resolution for ASC identification. Further analysis revealed a subpopulation of ASC in autoimmunity expressing high levels of CD39 and CD326.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Elodie Mohr, Timo Hinnenthal, Stefanie Gryzik, Yen Hoang, Timo Lischke, Jimmy Retzlaff, Ariana Mekonnen, Friedemann Paul, Angelo Valleriani, Andreas Radbruch, Julio Vera, Ria Baumgrass
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Mark S. Butler, Ian R. Henderson, Robert J. Capon, Mark A. T. Blaskovich
Summary: The global need for new antibacterial drugs to combat drug-resistant bacterial infections is receiving significant attention, leading to numerous funding, policy, and legislative initiatives to support antibacterial research and development. This review assesses the impact of these programs by analyzing the clinical development of various types of antibacterial drugs and the number of drug approvals in recent years. The findings show an increasing number of early-stage candidates and a presence of novel antibacterial compounds, particularly targeting Gram-negative bacteria.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Multidisciplinary Sciences
Ewan A. Ross, Lesley-Anne Turner, Hannah Donnelly, Anwer Saeed, Monica P. Tsimbouri, Karl V. Burgess, Gavin Blackburn, Vineetha Jayawarna, Yinbo Xiao, Mariana A. G. Oliva, Jennifer Willis, Jaspreet Bansal, Paul Reynolds, Julia A. Wells, Joanne Mountford, Massimo Vassalli, Nikolaj Gadegaard, Richard O. C. Oreffo, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: This study reveals that nanotopography can regulate the immunomodulatory capacity of MSCs by reducing intracellular tension and increasing oxidative glycolysis, providing an effective approach for large-scale expansion of functional MSCs for therapeutic purposes.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Emily C. A. F. Goodall, Camila Azevedo A. Antunes, Jens Moeller, Vartul R. Sangal, Von Vergel L. Torres, Jessica Gray, Adam F. Cunningham, Paul A. Hoskisson, Andreas Burkovski, Ian R. Henderson
Summary: This study constructed the densest library of mutants for any Corynebacterium species and identified the essential genome of Corynebacterium diphtheriae. The identification of highly conserved genes and species-specific genes provides a basis for the future development of therapeutic options. Additionally, the study discovered uncharacterized proteins in the proteome that are also represented in the vaccine, which could be potential targets for antimicrobial and vaccine development.