Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Summary: Research on multiple sclerosis and autoimmune diseases has found that targeting deoxycytidine kinase (dCK) can limit the progression of symptoms, and dCK activity is essential for activation-induced proliferation in specific lymphocytes.
Article
Immunology
Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Laijun Lai
Summary: ERMAP has been identified as a novel T cell inhibitory molecule, with its fusion protein inhibiting T cell functions and ameliorating autoimmune diseases in vitro. Additionally, anti-ERMAP antibody enhances macrophage phagocytosis of cancer cells and inhibits tumor growth in mice, likely through blocking ERMAP's inhibitory effects on T cells and macrophages. Therapeutic targeting of the ERMAP inhibitory pathway may offer a novel strategy for treating patients with autoimmune disease or cancer.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhigang Chen, Rong Fan, Jie Liang, Zexiu Xiao, Junlong Dang, Jun Zhao, Ruihui Weng, Cansheng Zhu, Song Guo Zheng, Ying Jiang
Summary: This study found that NFIL3 deficiency could alleviate MOG35-55-induced EAE by regulating different immune cell subsets, especially the crosstalk between CD4+ T cells and CD11c+ dendritic cells.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Peripheral Vascular Disease
Akiko Hiramatsu, Yuichiro Izumi, Koji Eguchi, Naomi Matsuo, Qinyuan Deng, Hideki Inoue, Yushi Nakayama, Hiroshi Nonoguchi, Jose Aramburu, Cristina Lopez-Rodriguez, Yutaka Kakizoe, Masataka Adachi, Takashige Kuwabara, Shokei Kim-Mitsuyama, Masashi Mukoyama
Summary: The study showed that renal tubular NFAT5 plays an important role in regulating sodium reabsorption through the epithelial sodium channel under high-salt conditions, thereby preventing salt-dependent hypertension.
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gil-Ran Kim, Won-Ju Kim, Sangho Lim, Hong-Gyun Lee, Ja-Hyun Koo, Kyung-Ho Nam, Sung-Min Kim, Sung-Dong Park, Je-Min Choi
Summary: The study demonstrates that a novel chimeric CTLA-4 signaling peptide can induce regulatory T cells effectively in vivo, showing potential therapeutic effects for autoimmune diseases such as multiple sclerosis.
Article
Multidisciplinary Sciences
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Summary: This study demonstrates that age-associated B cells (ABC) play a crucial role in sex-specific autoimmune diseases, particularly in the development of lupus-like syndrome in females. The absence of certain guanine exchange factors in double-knock-out (DKO) mice leads to the accumulation of ABCs, which differentiate into pathogenic effector B cell populations with pro-inflammatory function. The upregulation of Tlr7 in DKO males further enhances the dissemination and pathogenicity of ABCs, resulting in severe pulmonary inflammation and early mortality.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Klara Ruppova, Jong-Hyung Lim, Georgia Fodelianaki, Avery August, Ales Neuwirth
Summary: This study found enhanced abundance of eosinophils in the inflamed spinal cord during EAE progression, but these cells were not essential for the development of EAE.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Ping Shen, Madlen Rother, Ulrik Stervbo, Vicky Lampropoulou, Elisabeth Calderon-Gomez, Toralf Roch, Ellen Hilgenberg, Steffi Ries, Anja A. Kuehl, Luc Jouneau, Pierre Boudinot, Simon Fillatreau
Summary: This study demonstrates the critical role of neutrophils in the regulation of antigen-specific CD4(+) T cell expansion in lymph nodes, and the counter-regulatory role of TLR signaling in this process.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
David W. Scott
Summary: The use of CAR transduced T cells and engineered Tregs with specific receptors show great promise in cancer immunotherapy. Methods involving retroviral transduction of specific T-cell receptors, scFv, or antigens for various diseases models are discussed for their potential clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li
Summary: Baicalein (BAI), a natural flavonoid, has been found to alleviate clinical symptoms, demyelination, and inflammatory response in EAE mice. It inhibits M1 microglia/macrophage activation, decreases the expression of proinflammatory cytokines, and targets STAT1 to inhibit polarization. These findings suggest the potential use of BAI in the treatment of MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Samuel J. Duesman, Sandra Ortega-Francisco, Roxana Olguin-Alor, Naray A. Acevedo-Dominguez, Christine M. Sestero, Rajeshwari Chellappan, Patrizia De Sarno, Nabiha Yusuf, Adrian Salgado-Lopez, Marisol Segundo-Liberato, Selina Montes de Oca-Lagunas, Chander Raman, Gloria Soldevila
Summary: The transforming growth factor receptor III (T beta RIII) is a co-receptor that regulates T cell development in the immune system and controls the pathogenicity of autoreactive T cells in neuroinflammation. T beta RIII null mice showed increased severity of autoimmune central nervous neuroinflammatory disease and expanded numbers of IFN gamma(+) CD4(+) T cells. This suggests that T beta RIII may be involved in regulating the conversion of encephalitogenic Th17 to Th1 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Stefan Rosenberger, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Gabriela Riemekasten, Jens Y. Humrich
Summary: Treg cells play a regulatory role in controlling the activation and expansion of autoreactive CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Minghao Gong, Seung-Chu Choi, Yuk Pheel Park, Xueyang Zou, Ahmed S. Elshikha, Valerie A. Gerriets, Jeffrey C. Rathmell, Mansour Mohamazadeh, Laurence Morel
Summary: The expansion of follicular helper T (Tfh) cells in lupus can be reversed by inhibiting glycolysis or glutaminolysis. In a mouse model of lupus, gene expression and metabolome analysis revealed enhanced signaling and effector programs in Tfh cells. Metabolically, Tfh cells showed defective mitochondrial functions and specific anabolic programs including enhanced glutamate metabolism. Targeting these specific metabolic programs can potentially limit the expansion of pathogenic Tfh cells in lupus.
Article
Hematology
Ludovic Belle, Kimberle Agle, Vivian Zhou, Cheng Yin-Yuan, Richard Komorowski, Daniel Eastwood, Brent Logan, Jie Sun, Nico Ghilardi, Daniel Cua, Calvin B. Williams, Melanie Gaignage, Reece Marillier, Jacques van Snick, William R. Drobyski
Article
Medicine, Research & Experimental
Vivian Zhou, Kimberle Agle, Xiao Chen, Amy Beres, Richard Komorowski, Ludovic Belle, Carolyn Taylor, Fenlu Zhu, Dipica Haribhai, Calvin B. Williams, James Verbsky, Wendy Blumenschein, Svetlana Sadekova, Eddie Bowman, Christie Ballantyne, Casey Weaver, David A. Serody, Benjamin Vincent, Jonathan Serody, Daniel J. Cua, William R. Drobyski
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Immunology
Dipica Haribhai, Jennifer Ziegelbauer, Shuang Jia, Kyle Upchurch, Ke Yan, Erica G. Schmitt, Nita H. Salzman, Pippa Simpson, Martin J. Hessner, Talal A. Chatila, Calvin B. Williams
JOURNAL OF IMMUNOLOGY
(2016)
Editorial Material
Cell Biology
Jonathan C. Jeschke, Calvin B. Williams
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Immunology
Nathaniel J. Schuldt, Jennifer L. Auger, Justin A. Spanier, Tijana Martinov, Elise R. Breed, Brian T. Fife, Kristin A. Hogquist, Bryce A. Binstadt
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Jonathan C. Jeschke, Christopher G. Mayne, Jennifer Ziegelbauer, Christopher L. DeCiantis, Selina Singh, Suresh N. Kumar, Mariko Suchi, Yoichiro Iwakura, William R. Drobyski, Nita H. Salzman, Calvin B. Williams
MUCOSAL IMMUNOLOGY
(2018)
Article
Rheumatology
Daniel J. Lovell, Anne L. Johnson, Bin Huang, Beth S. Gottlieb, Paula W. Morris, Yukiko Kimura, Karen Onel, Suzanne C. Li, Alexei A. Grom, Janalee Taylor, Hermine I. Brunner, Jennifer L. Huggins, James J. Nocton, Kathleen A. Haines, Barbara S. Edelheit, Michael Shishov, Lawrence K. Jung, Calvin B. Williams, Melissa S. Tesher, Denise M. Costanzo, Lawrence S. Zemel, Jason A. Dare, Murray H. Passo, Kaleo C. Ede, Judyann C. Olson, Elaine A. Cassidy, Thomas A. Griffin, Linda Wagner-Weiner, Jennifer E. Weiss, Larry B. Vogler, Kelly A. Rouster-Stevens, Timothy Beukelman, Randy Q. Cron, Daniel Kietz, Kenneth Schikler, Kara M. Schmidt, Jay Mehta, Dawn M. Wahezi, Tracy V. Ting, James W. Verbsky, B. Anne Eberhard, Steven Spalding, Chen Chen, Edward H. Giannini
ARTHRITIS & RHEUMATOLOGY
(2018)
Article
Immunology
Jerott R. Moore, Shane L. Hubler, Corwin D. Nelson, Faye E. Nashold, Justin A. Spanier, Colleen E. Hayes
JOURNAL OF NEUROIMMUNOLOGY
(2018)
Article
Rheumatology
Claas H. Hinze, Dirk Foell, Anne L. Johnson, Steven J. Spalding, Beth S. Gottlieb, Paula W. Morris, Yukiko Kimura, Karen Onel, Suzanne C. Li, Alexei A. Grom, Janalee Taylor, Hermine I. Brunner, Jennifer L. Huggins, James J. Nocton, Kathleen A. Haines, Barbara S. Edelheit, Michael Shishov, Lawrence K. Jung, Calvin B. Williams, Melissa S. Tesher, Denise M. Costanzo, Lawrence S. Zemel, Jason A. Dare, Murray H. Passo, Kaleo C. Ede, Judyann C. Olson, Elaine A. Cassidy, Thomas A. Griffin, Linda Wagner-Weiner, Jennifer E. Weiss, Larry B. Vogler, Kelly A. Rouster-Stevens, Timothy Beukelman, Randy Q. Cron, Daniel Kietz, Kenneth Schikler, Jay Mehta, Tracy V. Ting, James W. Verbsky, Anne B. Eberhard, Bin Huang, Edward H. Giannini, Daniel J. Lovell
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Immunology
Xiaofeng Luo, Juan Chen, Jocelyn A. Schroeder, Kenneth P. Allen, Christina K. Baumgartner, Subramaniam Malarkannan, Jianda Hu, Calvin B. Williams, Qizhen Shi
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
David L. Owen, Shawn A. Mahmud, Louisa E. Sjaastad, Jason B. Williams, Justin A. Spanier, Dimitre R. Simeonov, Roland Ruscher, Weishan Huang, Irina Proekt, Corey N. Miller, Can Hekim, Jonathan C. Jeschke, Praful Aggarwal, Ulrich Broeckel, Rebecca S. LaRue, Christine M. Henzler, Maria-Luisa Alegre, Mark S. Anderson, Avery August, Alexander Marson, Ye Zheng, Calvin B. Williams, Michael A. Farrar
Article
Immunology
Yongwei Zheng, Wen Zhu, Dipica Haribhai, Calvin B. Williams, Richard H. Aster, Renren Wen, Demin Wang
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Elena N. Naumova, Maryam B. Yassai, Wendy Demos, Erica Reed, Melissa Unruh, Dipica Haribhai, Calvin B. Williams, Yuri N. Naumov, Jack Gorski
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Jing Li, Juan Chen, Jocelyn A. Schroeder, Jianda Hu, Calvin B. Williams, Qizhen Shi
Summary: Platelet-specific gene therapy can achieve robust antigen-specific immune tolerance through peripheral clonal deletion of antigen-specific CD4 and CD8 T effector cells and induction of antigen-specific Treg cells. There is an antagonistic dynamic process between immune responses and immune tolerance after platelet-targeted gene therapy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Endocrinology & Metabolism
Justin A. Spanier, Nathanael L. Sahli, Joseph C. Wilson, Tijana Martinov, Thamotharampillai Dileepan, Adam L. Burrack, Erik B. Finger, Bruce R. Blazar, Aaron W. Michels, Antoinette Moran, Marc K. Jenkins, Brian T. Fife