Article
Immunology
Maulik Vyas, Marta Requesens, Thao H. Nguyen, Domitille Peigney, Marjan Azin, Shadmehr Demehri
Summary: Despite advances in cancer treatment, metastatic spread of malignant cells remains a major cause of cancer-related deaths. Natural killer (NK) cells and T cells play cooperative roles in the surveillance and control of melanoma metastasis. NK cells limit the seeding of melanoma cells in the lungs, while T cells restrict the growth of metastatic foci. The liver is a prominent site where NK cells clear melanoma cells to regulate their seeding in the lungs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Brenna Labere, Alan A. Nguyen, Saddiq B. Habiballah, Megan Elkins, Juliet Imperial, Betty Li, Sridevi Devana, Suraj Timilsina, Spencer B. Stubbs, Jill Joerger, Janet Chou, Craig D. Platt
Summary: This study identifies cTfh cells as potential markers for autoimmune disorders, with a specific percentage threshold distinguishing different types of immune dysregulation.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Immunology
Chen Dong
Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Ning Huang, Hao Dong, Yuqi Luo, Bin Shao
Summary: Periodontitis is a chronic disease driven by pathogens and inflammation, modulated by the immune system, particularly Th17 cells. Th17 cells play a key role in driving periodontal inflammation and their cytokines are major players in the pathogenesis of periodontitis. Understanding regulators of Th17 cells is crucial for potential clinical interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nana Zhang, Xiaoli Li, Junning Wang, Jinye Wang, Na Li, Yao Wei, Hua Tian, Yahong Ji
Summary: IPAF is a disease characterized by autoimmunity and pulmonary fibrosis, and the deficiency of Gal-9 in Tfh cells may lead to abnormal chronic lung fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Jiangshan Zhan, Markus Kipp, Wenling Han, Hannes Kaddatz
Summary: Ectopic lymphoid follicles (ELFs), similar to germinal center-like structures, are present in various infectious, autoimmune, and neoplastic diseases, and are associated with disease progression and cortical degeneration in progressive multiple sclerosis. However, the lack of a uniform definition of ELFs impedes reproducible and comparable neuropathological research in this field.
Article
Immunology
Angelina De Martin, Yves Stanossek, Mechthild Lutge, Nadine Cadosch, Lucas Onder, Hung-Wei Cheng, Joshua D. Brandstadter, Ivan Maillard, Sandro J. Stoeckli, Natalia B. Pikor, Burkhard Ludewig
Summary: Human tonsillar fibroblastic reticular cells undergo dynamic reprogramming during life and exhibit strong response to inflammation. The subset of PI16-expressing reticular cells plays a specialized role in mucosal immune responses.
Article
Cell Biology
Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban Jr, Keji Zhao, Warren J. Leonard, Jinfang Zhu
Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) play a protective role in helminth infection and allergies, but their importance and interaction in type 2 immune responses are still debated.
Article
Rheumatology
Johannes Fessler, Patrizia Fasching, Andrea Raicht, Sabrina Hammerl, Jennifer Weber, Angelika Lackner, Josef Hermann, Christian Dejaco, Winfried B. Graninger, Wolfgang Schwinger, Martin H. Stradner
Summary: In primary Sjogren's syndrome (pSS), peripheral lymphopenia is associated with decreased proliferation and signs of immune cell aging in naive CD4(+) T cells. Shortened telomeres, reduced telomerase activity, and low levels of T-cell receptor excision circles (TRECs) suggest a history of extensive post-thymic cell division. This senescent phenotype in naive CD4(+) T cells may contribute to the inability to sustain cell numbers and ultimately leads to lymphopenia in pSS.
Article
Pharmacology & Pharmacy
Zhiwen Liu, Huihui Chen, Chongqing Tan, Jie Zha, Hong Liu, Guochun Chen
Summary: This study investigated the effects of long-term glucocorticoid (GC) exposure on circulating T cells in patients with primary glomerular diseases. The results showed that GCs altered the composition and correlation of circulating leukocytes and lymphocytes, as well as the subsets of CD4 + T cells. Long-term GC exposure exacerbated apoptosis of CD4 + T cells and cytokine storm during sepsis, which was mechanistically linked to the increase of CD3 + TIM3 + T cells. CD3 + TIM3 + T cells expressed high levels of multiple cytokine genes during infections and engagement of anti-TIM3 treatment enhanced the inflammatory activity of CD3 + T cells.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake
Summary: Tregs play a protective role in atherosclerosis by regulating immune responses to prevent and treat the development of the disease. Enhancing regulatory immune responses may be an attractive approach to treating atherosclerotic diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Hanan E. Alrashidi, Amna A. Alotiby
Summary: This study found that zinc supplementation can increase the number of T regulatory cells (Tregs) and slightly decrease the number of T helper 17 cells (Th17). Zinc can reduce the production of IFN gamma, but its effect on IL10 is not significant. In mixed lymphocyte cultures, zinc supplementation significantly increases the expression of Tregs-specific transcription factors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Patricia Sole, Jun Yamanouchi, Josep Garnica, Muhammad Myn Uddin, Robert Clarke, Joel Moro, Nahir Garabatos, Shari Thiessen, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, Cesar Fandos, Julio Saez-Rodriguez, Yang Yang, Pau Serra, Pere Santamaria
Summary: Chronic antigenic stimulation can induce the differentiation of CD4(+) T cells into T regulatory type 1 (TR1) cells, which produce interleukin-10 and do not express FOXP3. The progenitors and transcriptional regulators of this T-cell subset are still unknown.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Immunology
Charles E. Egwuagu, Sahar A. Alhakeem, Evaristus C. Mbanefo
Summary: Understanding the etiology and clinical management of potentially blinding diseases is crucial due to the significant impact of vision loss on human activities and quality of life. The unique anatomical features and immune sequestration of the eye have provided insights into studying diseases in immune privileged sites, leading to foundational discoveries in immunology. Advances in molecular cell biology and immunology over the past 3 decades have contributed to unraveling the mechanisms underlying the immunopathogenesis of uveitis, with particular emphasis on the development of biologics and cell-based immunotherapies for uveitis and other neuroinflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Vanessa Chenouard, Severine Remy, Laurent Tesson, Severine Menoret, Laure-Helene Ouisse, Yacine Cherifi, Ignacio Anegon
Summary: This review discusses the extensive use of rats as small animal models in genetic engineering, focusing on their application in human genetic diseases and immune system analysis. It also highlights the competitive advantages of rat models over mouse models, particularly in addressing specific scientific questions.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Xin Yu, Linfeng Li, Matthew T. V. Chan, William Ka Kei Wu
Summary: Research suggests that there may be a correlation between herpes zoster and COVID-19 through similar subset of genes involved in cytokine-cytokine receptor interaction. Both diseases show augmented Th17 cell differentiation and IL-17 signaling.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Microbiology
Oluropo A. Apalowo, Adedapo O. Adediji, Olusegun S. Balogun, Temitope I. Fakolujo, Joy M. Archibong, Nkechi B. Izuogu, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Suleiman Mustapha, Fadi S. I. Qashqari, Gaber E. Batiha, Gabriel I. Atiri
Summary: This study describes the population structure of Cucumber mosaic virus (CMV) in Nigeria, revealing high genetic diversity and putative novel strains within the population. Recombination signals were detected within the CMV genome, and the Nigerian population showed higher diversity compared to isolates from other regions. Furthermore, this study highlights the prevalence of CMV subgroup IB strains across different hosts in Nigeria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tian Zhou, Chang He, Peilong Lai, Ziqi Yang, Yan Liu, Huiyi Xu, Xiaojing Lin, Biyan Ni, Rong Ju, Wei Yi, Lingyi Liang, Duanqing Pei, Charles E. Egwuagu, Xialin Liu
Summary: Exosomes from mesenchymal stromal cells administered as eye drops alleviate graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery. The study highlights the potential of miR-204 as a therapeutic agent.
Article
Medicine, General & Internal
Beatriz G. Galvez, Clara Martinez-Perez, Cesar Villa-Collar, Cristina Alvarez-Peregrina, Miguel Angel Sanchez-Tena
Summary: This study used citation networks to analyze the relationship between different publications on the impact of cytokines at an ocular level and their authors. The main research areas were identified and the most cited publications were determined.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Summary: Interleukin-27 (IL-27) and Interleukin-35 (IL-35) have different roles in neuroinflammation and uveitis. IL-27 can suppress encephalomyelitis and autoimmune uveitis, while IL-35 may have a protective role in the retina by constitutive secretion to counteract persistent low-grade inflammation. Decreased expression of IL-35 leads to increased severity of uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Can Lu, Xiaopeng Zhang, Yang Luo, Jingang Huang, Minhao Yu
Summary: This study identified CXCL10 and CXCL11 as candidate genes involved in the tumorigenesis of CAC and potential therapeutic targets to prevent the development of CAC from UC.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Shiheng Lu, Hui Wang, Jian Zhang
Summary: In this study, advanced machine learning methods were used to identify key functions and biological processes related to uveitis, providing a theoretical foundation for the clinical treatment of the disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Zhengrong Jiang, Linghong Huang, Lijun Chen, Jingxiong Zhou, Bo Liang, Xuefeng Bai, Lizhen Wu, Huibin Huang
Summary: This study identified 366 significantly differentially expressed circular RNAs in Graves' disease patients compared to healthy controls, and found that the elevation of hsa_circ_0090364 is positively correlated with thyroid-stimulating hormone receptor antibodies in Graves' disease patients. Further analysis suggested that hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth.
ENDOCRINE CONNECTIONS
(2022)
Review
Cell Biology
Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K. James, Niels Olsen Saraiva Camara, S. M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Zheng Liu, Chaohong Liu
Summary: In this article, the authors summarize the regulatory relationship between B cells and T cells, mainly focusing on T follicular regulatory cells and regulatory B cells. They introduce a new subset of regulatory T cells induced by B cells, and discuss the role of B cells in ensuring the survival of regulatory T cells. This review provides an updated overview of immunoregulatory networks and identifies potential targets for therapeutic interventions against cancer, autoimmune diseases, and allograft rejection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Breann Green, Travis W. Ford, Heather Goldsborrough, Mohamed Abdelmotalab, Andrew G. Ristvey, Deborah G. Sauder, Victoria V. Volkis
Summary: Antioxidants are crucial for defending cells from damage, and Aronia mitschurinii, a fruit with high levels of antioxidants, can be effectively extracted using resin technology for various applications, showcasing the importance of this research in the food industry.
Article
Immunology
Minkyung Kang, Manoj Kumar Yadav, Evaristus C. Mbanefo, Cheng-Rong Yu, Charles E. Egwuagu
Summary: IL-27 is a heterodimeric cytokine that can have proinflammatory or immune suppressive effects. This study identified a new population of B cells that produce IL-27 and suppress neuroinflammation by secreting IL-27-containing exosomes. These findings suggest that exosomes could be a promising therapeutic approach for CNS autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Qian Zhang, Fangyan Liu, Meng Zeng, Jinping Zhang, Yanfei Liu, Caiyan Xin, Yingyu Mao, Zhangyong Song
Summary: The study found that SNH may be a promising antifungal agent for the treatment of A. fumigatus infection, with significant anti-fungal activity. It interfered with the fungal cell steroid synthesis pathway and inhibited ergosterol synthesis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jin Kyeong Choi, Cheng-Rong Yu, So Jin Bing, Yingyos Jittayasothorn, Mary J. Mattapallil, Minkyung Kang, Seung Bum Park, Hyun-Su Lee, Lijin Dong, Guangpu Shi, Rachel R. Caspi, Charles E. Egwuagu
Summary: Natural regulatory B-1a cells producing IL-27 (i27-Bregs) have been identified in the peritoneal cavity and human umbilical cord blood, accumulating in the CNS during neuroinflammation to confer protection against autoimmune diseases. i27-Breg immunotherapy ameliorated encephalomyelitis and uveitis through up-regulating inhibitory receptors, suppressing immune responses, and converting conventional B cells to secrete IL-10 and/or IL-35.Mutation of irf4 in B cells resulted in increased i27-Bregs with few i35-Bregs, while loss of irf8 led to an abundance of i35-Bregs but impaired generation of i27-Bregs, suggesting the role of IRF8/BATF and IRF4/BATF axis in regulating B cell differentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)