Article
Multidisciplinary Sciences
Kathrin Koedderitzsch, Ekaterina Zezina, Lingzi Li, Matthias Herrmann, Nadine Biesemann
Summary: The study revealed a direct role of TNF in the glycolytic reprogramming of FLS, confirming the potency of immunometabolism in RA. TNF stimulation was shown to enhance glycolysis, reduce GLUT1 and GAPDH levels, which may be linked to treatment response in patients.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Jiajie Tu, Weile Chen, Yilong Fang, Dafei Han, Yizhao Chen, Haifeng Jiang, Xuewen Tan, Zhen Xu, Xuming Wu, Huihui Wang, Xiangling Zhu, Wenming Hong, Zhenbao Li, Chen Zhu, Xinming Wang, Wei Wei
Summary: This study investigates the function and mechanism of PU.1, a crucial transcription factor, in the development of rheumatoid arthritis (RA). The results demonstrate the role of PU.1 in RA and suggest that targeting PU.1 could be a potential therapeutic approach by repressing FLT3.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeno, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Summary: The mitochondrial binding of glucose metabolism enzyme HK2 plays a crucial role in regulating the phenotype of rheumatoid arthritis fibroblast-like synoviocytes (FLS). It was found that HK2 protects mitochondria against stress and regulates the aggressive phenotype of RA FLS. New therapeutic approaches focusing on dissociating HK2 from mitochondria offer a safer option for inhibiting the progression of RA FLS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Dorra Elhaj Mahmoud, Wajih Kaabachi, Nadia Sassi, Amel Mokhtar, Myriam Moalla, Lobna Ben Ammar, Samia Jemmali, Sonia Rekik, Lamjed Tarhouni, Maryam Kallel-Sellami, Elhem Cheour, Lilia Laadhar
Summary: RA td-FLS, fd-FLS, and fibrocytes from patients express similar levels of Wnt5a and its receptors/coreceptors. Wnt5a stimulates pro-inflammatory targets in RA td-FLS, especially IL1 beta, IL8, and IL6, and this inflammation is enhanced in the presence of SFRP5. Additionally, Wnt5a and SFRP5 inhibit the expression of TCF4 and the canonical coreceptor LRP5.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Summary: The study demonstrates that tofacitinib has the ability to modulate autophagy in fibroblast-like synoviocytes, contributing to its effectiveness in treating patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ji Hyeon Ryu, Jisu Park, Bo-Young Kim, Yeonye Kim, Nam Gyun Kim, Yong-Il Shin
Summary: This study investigates the effects and mechanisms of photobiomodulation (PBM) on fibroblast-like synoviocytes (FLSs) from rheumatoid arthritis (RA) patients and a mouse model of collagen-induced arthritis (CIA). PBM significantly reduced proliferation, migration, and invasion of RA-FLSs, and inhibited synovial inflammation and cartilage degradation in the CIA model. PBM therapy also showed a synergistic effect when combined with methotrexate (MTX), a disease-modifying anti-rheumatic drug (DMARD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ling-ling Zhang, Hui Xiao, Feng Zhang, Yu-jing Wu, Jin-ling Shu, Ying Li, Yu Tai, Sheng-qian Xu, Jian-hua Xu, Wei Wei
Summary: The study found that the serum BAFF level is significantly higher in rheumatoid arthritis patients, and is positively correlated with clinical variables, laboratory parameters, and X-ray scores. BAFF is involved in the differentiation, proliferation, and activation of B cells in rheumatoid arthritis through the NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Robin Caire, Estelle Audoux, Guillaume Courbon, Eva Michaud, Claudie Petit, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Arnaud Vanden-Bossche, Laurent Navarro, Marie-Therese Linossier, Sylvie Peyroche, Alain Guignandon, Laurence Vico, Stephane Paul, Hubert Marotte
Summary: The study indicates that YAP/TAZ play crucial roles in arthritis, and their transcriptional inhibition may be relevant for treating inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Dermatology
Renaud Felten, Dan Lipsker, Jean Sibilia, Francois Chasset, Laurent Arnaud
Summary: The term lupus has been used since the Middle Ages to refer to several diseases characterized by ulcerous lesions. In the 19th century, a distinction between different types of lupus emerged, and the systemic nature of the disease was recognized. Modern treatments such as glucocorticoids, hydroxychloroquine, and immunosuppressive agents emerged in the second half of the 20th century. In the 21st century, there has been a deeper understanding of the disease's pathogenesis and the development of biologic and targeted treatments.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Thierry Pelaccia, Jean Sibilia, Elodie Fels, Lucas Gauer, Audrey Musanda, Francois Severac, Milena Abbiati
Summary: The COVID-19 pandemic has led to increased staffing needs in emergency departments, sparking debates on whether medical students should assist. A study conducted at Strasbourg Medical School found that anxiety levels among medical students were higher in 2020 compared to 2018, especially for those who chose not to return to clinical settings. Gender and perceived clinical activity personal conditions were identified as main factors associated with anxiety, while working in clinical settings during the outbreak was not a risk factor for anxiety, suggesting it as an active coping strategy.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Rheumatology
Marc Scherlinger, Johanna Lutz, Gael Galli, Christophe Richez, Jacques-Eric Gottenberg, Jean Sibilia, Laurent Arnaud, Patrick Blanco, Thierry Schaeverbeke, Emmanuel Chatelus, Marie-Elise Truchetet
Summary: This study found significant differences in clinical characteristics and prognosis in patients with systemic sclerosis who have concomitant autoimmune diseases. Patients with overlap SgS/SSc had a higher risk of mortality, while those with RA/SSc received more medication treatments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Dan Levy, Benoit Nespola, Margherita Giannini, Renaud Felten, Francois Severac, Coralie Varoquier, Marina Rinagel, Anne-Sophie Korganow, Thierry Martin, Vincent Poindron, Francois Maurier, Haitham Chereih, Bastien Bouldoires, Baptiste Hervier, Cedric Lenormand, Emmanuel Chatelus, Bernard Geny, Jean Sibilia, Laurent Arnaud, Jacques-Eric Gottenberg, Alain Meyer
Summary: In myositis patients, Sjogren's syndrome is associated with inclusion body myositis and anti-cN1A antibodies, independently of the IBM diagnosis. As a consequence, anti-cN1A has limited specificity for IBM in myositis patients with Sjogren's syndrome.
Letter
Rheumatology
Renaud Felten, Pierre-Marie Duret, Elodie Bauer, Nathanael Sedmak, Julien H. Djossou, Massiva Bensalem, Marc Ardizzone, Marion Geoffroy, Angelique Fan, Marion Couderc, Jean Hugues Salmon, Laurent Messer, Rose-Marie Javier, Alain Meyer, Emmanuel Chatelus, Christelle Sordet, Luc Pijnenburg, Jeremy Fort, Marina Rinagel, Julia Walther, Cassandre Fabre, Laurent Arnaud, Jean Sibilia, Nicolas Meyer, Francis Berenbaum, Isabelle Chary-Valckenaere, Martin Soubrier, Jeremie Sellam, Jacques-Eric Gottenberg
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
L. Widawski, T. Fabacher, L. Spielmann, J. E. Gottenberg, J. Sibilia, P. M. Duret, L. Messer, R. Felten
Summary: This study aimed to investigate the effects of hyperuricemia on the clinical presentation, severity, and associated comorbidities of psoriatic arthritis (PsA). The results showed that patients with hyperuricemic PsA had a higher prevalence of male gender, higher body mass index, and more comorbidities compared to patients with normal uric acid levels. Hyperuricemic PsA was associated with older age at onset, more polyarticular and destructive joint involvement. Additionally, hyperuricemic PsA patients had a poorer response to treatment and more peripheral joint damage than normo-uricemic patients.
CLINICAL RHEUMATOLOGY
(2022)
Article
Cell Biology
Raphael Carapito, Richard Li, Julie Helms, Christine Carapito, Sharvari Gujja, Veronique Rolli, Raony Guimaraes, Jose Malagon-Lopez, Perrine Spinnhirny, Alexandre Lederle, Razieh Mohseninia, Aurelie Hirschler, Leslie Muller, Paul Bastard, Adrian Gervais, Qian Zhang, Francois Danion, Yvon Ruch, Maleka Schenck, Olivier Collange, Thien-Nga Chamaraux-Tran, Anne Molitor, Angelique Pichot, Alice Bernard, Ouria Tahar, Sabrina Bibi-Triki, Haiguo Wu, Nicodeme Paul, Sylvain Mayeur, Annabel Larnicol, Geraldine Laumond, Julia Frappier, Sylvie Schmidt, Antoine Hanauer, Cecile Macquin, Tristan Stemmelen, Michael Simons, Xavier Mariette, Olivier Hermine, Samira Fafi-Kremer, Bernard Goichot, Bernard Drenou, Khaldoun Kuteifan, Julien Pottecher, Paul-Michel Mertes, Shweta Kailasan, M. Javad Aman, Elisa Pin, Peter Nilsson, Anne Thomas, Alain Viari, Damien Sanlaville, Francis Schneider, Jean Sibilia, Pierre-Louis Tharaux, Jean-Laurent Casanova, Yves Hansmann, Daniel Lidar, Mirjana Radosavljevic, Jeffrey R. Gulcher, Ferhat Meziani, Christiane Moog, Thomas W. Chittenden, Seiamak Bahram
Summary: In this study, multi-omics analysis and artificial intelligence were used to examine the differences in biological factors between critical and non-critical COVID-19 patients in a young and otherwise healthy cohort. The study identified ADAM9 as a driver of disease severity and a potential therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Isis Benoit-Lizon, Elise Jacquin, Thaiz Rivera Vargas, Corentin Richard, Aurelie Roussey, Ludivine Dal Zuffo, Tiffany Martin, Andrea Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stephane Giorgiutti, Raphael Carapito, Romain Boidot, Frederique Vegran, Richard A. Flavell, Bernhard Ryffel, Eric R. Nelson, Pauline Soulas-Sprauel, Toby Lawrence, Lionel Apetoh
Summary: Activation of STING signaling enhances the differentiation and antitumor functions of T(H)1 and T(H)9 cells by increasing their production of IFN-gamma and interleukin-9, respectively. IRF3 and IFNARs are required for the enhancement of T(H)1 cell differentiation, while mTOR signaling is implicated in T(H)9 cell differentiation in response to STING activation. STING activation boosts the antitumor activity of T(H)1 and T(H)9 cells through their cytokine production, and enhances the efficacy of T(H)9 cells in adoptive transfer against melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Marc Scherlinger, Luc Pijnenburg, Emmanuel Chatelus, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Sibilia, Renaud Felten
Summary: This study suggests that SARS-CoV-2 vaccination is well tolerated and immunogenic in the majority of patients with long-COVID or post-acute sequelae of COVID-19 (PASC). Disseminating these reassuring data might prove crucial to increasing vaccine coverage in patients with PASC.
Editorial Material
Rheumatology
Renaud Felten, Floriane Gallais, Cedric Schleiss, Emmanuel Chatelus, Rose-Marie Javier, Luc Pijnenburg, Christelle Sordet, Jean Sibilia, Laurent Arnaud, Samira Fafi-Kremer, Jacques-Eric Gottenberg
LANCET RHEUMATOLOGY
(2022)
Editorial Material
Rheumatology
Jean-Marie Berthelot, Frederic Liote, Jean Sibilia
Letter
Immunology
Aurelien Guffroy, Yannick Dieudonne, Vincent Gies, Francois Danion
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Review
Rheumatology
Ghada Alsaleh, Felix C. Richter, Anna K. Simon
Summary: This review discusses the involvement of ageing hallmarks in rheumatic diseases and suggests that these chronic conditions can be considered as diseases of premature or accelerated ageing. It also proposes that targeting age-related pathways may provide new therapeutic interventions for patients with rheumatic diseases.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Felix Clemens Richter, Matthias Friedrich, Nadja Kampschulte, Klara Piletic, Ghada Alsaleh, Ramona Zummach, Julia Hecker, Mathilde Pohin, Nicholas Ilott, Irina Guschina, Sarah Karin Wideman, Errin Johnson, Mariana Borsa, Paula Hahn, Christophe Morriseau, Bruce D. Hammock, Henk Simon Schipper, Claire M. Edwards, Rudolf Zechner, Britta Siegmund, Carl Weidinger, Nils Helge Schebb, Fiona Powrie, Anna Katharina Simon
Summary: Lipids play a major role in inflammatory diseases through altering inflammatory cell functions. Autophagy, a lysosomal degradation pathway, is found to regulate lipid availability, which affects inflammation. Loss of autophagy gene Atg7 in adipocytes exacerbates intestinal inflammation by causing an imbalance of oxylipins, reducing IL-10 secretion, and exacerbating intestinal inflammation through the cytochrome P450-EPHX pathway.
Article
Rheumatology
Arthur Petitdemange, Renaud Felten, Jean Sibilia, Thierry Martin, Laurent Arnaud
Summary: The study reveals significant heterogeneity in antimalarial agent prescription among physicians treating lupus, with key unmet needs identified regarding this treatment approach. This highlights the importance of developing more comprehensive recommendations and promoting dissemination among healthcare providers.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)