期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 41, 期 7, 页码 1850-1861出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201141472
关键词
Antigen processing and presentation; Apoptosis; B cell; CD4(+) T cell; Relocation
类别
资金
- Royal Victoria Infirmary Breast Cancer Appeal Ph.D. studentship
The induction of an effective immune response requires the activation of CD4(+) T lymphocytes by APCs. While DCs have been shown to be pivotal in this process, it is now apparent that optimal CD4(+) T-cell activation also requires B-lymphocyte APC function. Along with the acquisition of soluble antigens, it is known that B cells also acquire membrane-tethered antigens. Recent reports have described the relocation of intracellular antigens to the cell surface following immunogenic apoptosis. This study was designed to determine whether B cells can acquire and present such antigens to CD4(+) T cells. By targeting the model antigen tetanus toxin C fragment to various cellular locations, we show that antigen-specific B cells acquire intracellular antigens that have relocated to the surface of cells undergoing immunogenic apoptosis. Crucially, we also demonstrate that antigen-specific B cells acquiring relocated antigen from apoptotic targets are capable of efficiently inducing CD4(+) T-cell activation. We propose that the acquisition and presentation of intracellular antigens that have relocated to the cell surface during immunogenic apoptosis represents a novel means by which antigen-specific B cells contribute to the generation of immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据