Article
Biochemistry & Molecular Biology
Federica Pierucci, Antony Chirco, Elisabetta Meacci
Summary: Irisin is a hormone-like myokine that is produced in skeletal muscle in response to exercise. Sphingosine-1-phosphate (S1P), a bioactive lipid, plays a crucial role in the formation and release of irisin. It also has autocrine and paracrine effects on myoblast proliferation and differentiation. These findings suggest that the S1P/S1PR axis could be a potential therapeutic target for muscle dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rachel S. Resop, Bradley Salvatore, Shawn J. Kim, Brent R. Gordon, Bianca Blom, Dimitrios N. Vatakis, Christel H. Uittenbogaart
Summary: HIV-1 infection leads to upregulation of S1P receptor 1 (S1PR1) in the human thymus, potentially increasing the number and speed of thymocyte egress. This may have implications for immune function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yadi Tang, Thomas Ploetz, Markus H. Graeler, Ewa Gurgul-Convey
Summary: This study reveals that the regulation of SPL may be crucially involved in the susceptibility of pancreatic beta-cells to lipotoxicity, as SPL plays an important role in modulating the damage process of pancreatic beta-cells induced by FFAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Article
Ophthalmology
Marcela S. Vera, M. Victoria Simon, Facundo H. Prado Spalm, Victoria B. Ayala-Pena, O. Lorena German, Luis E. Politi, Florencia X. Santiago Valtierra, Nora P. Rotstein
Summary: This study demonstrated that Ceramide-1-phosphate (C1P) can promote the migration of Muller glial cells by activating cPLA2, PI3K, and ERK/MAPK pathways. In addition, CerK-mediated C1P synthesis contributes to glial cell migration, suggesting a novel role of C1P in controlling glial motility.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Cell Biology
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo
Summary: Psoriasis is a chronic skin condition that lacks a complete cure. Recent studies have identified sphingolipid metabolites as significant contributors to psoriasis, particularly ceramide and sphingosine-1-phosphate (S1P). The modulation of S1P and its receptor has shown potential in improving psoriasis inflammation.
Article
Medicine, Research & Experimental
Daniela Judith Romero, Lucila Gisele Pescio, Bruno Jaime Santacreu, Jazmin Maria Mosca, Norma Beatriz Sterin-Speziale, Nicolas Octavio Favale
Summary: Epithelial renal cells can adopt different cellular phenotypes through epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). Sphingosine-1-phosphate (S1P) plays a crucial role in cell migration and differentiation, and its functions vary depending on the stage of cell differentiation and activation of S1P receptor 2 (S1PR2). Activation of S1PR2 promotes migration in fully differentiated cells but inhibits migration in non-differentiated cells. These findings provide new insights into the modulation of renal epithelial cell plasticity and have implications for research in various diseases.
Article
Virology
Rachel S. Resop, Alberto Bosque
Summary: Inhibition of SPHK can reduce HIV-1 transmission between CD4 T cells and decrease susceptibility to infection, which may serve as a basis for developing strategies to prevent HIV-1 infection.
JOURNAL OF VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Shenghui Chu, Rui Sun, Xuemei Gu, Liang Chen, Min Liu, HaiXun Guo, Songwen Ju, Vatsalya Vatsalya, Wenke Feng, Craig J. McClain, Zhongbin Deng
Summary: Chronic alcohol consumption leads to intestinal inflammation, which plays a crucial role in the pathogenesis of ALD. Modulating gut Th17 cells can reduce liver damage. S1P signaling is essential for the development of ALD mediated by Th17 cells.
Article
Biochemistry & Molecular Biology
Janik Riese, Alina Gromann, Felix Luehrs, Annabel Kleinwort, Tobias Schulze
Summary: This study found that under inflammatory conditions, S1P-mediated signaling controls the migration of peritoneal B cells, and deficiency of S1P(4) affects the trafficking of activated peritoneal B cells to secondary lymphoid organs and their positioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xuehui Fan, Lili Liu, Yue Shi, Fanghan Guo, Xiao He, Xiuli Zhao, Di Zhong, Guozhong Li
Summary: Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite found in various cells and body fluids, with five receptors, S1P1-S1P5, exhibiting tissue selectivity. Among these receptors, S1P3 plays a crucial role in processes related to inflammation, cell migration, tumor invasion and metastasis, and other pathophysiological processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kumar Saurabh, Magdaleena Naemi Mbadhi, Kevin K. Prifti, Kaci T. Martin, Antonina Frolova
Summary: Abnormal uterine contractility is a common mechanism for obstetric complications, affecting millions of women annually. The activation of sphingolipid metabolism, specifically sphingosine 1-phosphate (S1P), during human labor may modify the myometrial proinflammatory phenotype. By activating S1P receptor 3 (S1PR3) and downstream ERK1/2 pathways, S1P induces a proinflammatory gene signature and upregulates expression of known inflammatory markers of labor.
Article
Biochemistry & Molecular Biology
Rachel S. Knipe, Jillian J. Spinney, Elizabeth A. Abe, Clemens K. Probst, Alicia Franklin, Amanda Logue, Francesca Giacona, Matt Drummond, Jason Griffith, Patricia L. Brazee, Lida P. Hariri, Sydney B. Montesi, Katherine E. Black, Timothy Hla, Andrew Kuo, Andreane Cartier, Eric Engelbrecht, Christina Christoffersen, Barry S. Shea, Andrew M. Tager, Benjamin D. Medoff
Summary: Idiopathic pulmonary fibrosis is a chronic disease that causes respiratory failure. This study reveals the importance of vascular permeability in lung repair and fibrosis following injury, and the potential role of lipid mediator S1P in regulating this process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)