期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 39, 期 8, 页码 2100-2105出版社
WILEY
DOI: 10.1002/eji.200939550
关键词
CD4(+) T cells; Innate imprinting; Protective immunity
类别
资金
- Novartis Vaccines and Diagnostics
The goal of vaccination is to induce long-lasting protective immune memory. Although most vaccines induce good memory responses, the type of memory induced by different vaccines may be considerably different. in addition, memory responses to the same vaccine may be influenced by age, environmental and genetic factors. Results emerging from detailed and integrated profiling of immune-responses to natural infection or vaccination suggest that the type and duration of immune memory are largely determined by the magnitude and complexity of innate immune signals that imprint the acquired immune primary responses. Here we summarize results obtained from analyzing human immune memory responses to different types of vaccines. We will also discuss how extending clinical investigation to events occurring early after vaccination can help identify early predictive markers of protective memory and thus contribute to faster development of better and safer vaccines.
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