Review
Cell Biology
Zewde Ingram, Shriya Madan, Jenoy Merchant, Zakiya Carter, Zen Gordon, Gregory Carey, Tonya J. Webb
Summary: NKT cells have the potential to play a role in cancer therapy by directly and indirectly mediating anti-tumor immune responses, and manipulating their effector functions is crucial for cancer treatment.
Article
Multidisciplinary Sciences
Catarina F. Almeida, Dylan G. M. Smith, Tan-Yun Cheng, Chris M. Harpur, Elena Batleska, Catriona V. Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J. J. Reddiex, Shihan Li, Sidonia B. G. Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P. Uldrich, D. Branch Moody, Spencer J. Williams, Daniel G. Pellicci, Dale Godfrey
Summary: A study found that nonlipidic small molecules activate a polyclonal population of type II NKT cells in a CD1d-restricted manner in human donors, with the combination of PPBF and short-chain sphingomyelin enhancing CD1d tetramer staining.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Vipin Kumar, Marc Hertz, Albert Agro, Adam J. Byrne
Summary: Chronic tissue inflammation can lead to fibrosis, and the activation of natural killer T cells plays a key role in the development of fibrosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maren Rudolph, Yuting Wang, Theresa Simolka, Emilie Huc-Claustre, Lingyun Dai, Gijsbert Grotenbreg, Gurdyal Singh Besra, Anna Shevchenko, Andrej Shevchenko, Sebastian Zeissig
Summary: Researchers have developed a novel system to analyze CD1d-bound lipids in mammalian cells and have gained new insights into the spectrum of CD1d-associated lipids, with important functional implications for NKT cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mariana S. Cruz, Jose Pedro Loureiro, Maria J. Oliveira, Maria Fatima Macedo
Summary: Invariant natural killer T (iNKT) cells and macrophages play crucial roles in maintaining homeostasis and regulating the progression of various diseases. Their interplay is important in diseases such as infection, obesity, sterile inflammation, cancer, and autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Michael S. Lee, Tonya J. Webb
Summary: Cancer immunotherapy aims to harness the immune system's power to fight tumors while avoiding the side effects of traditional chemotherapy. iNKT cells, a type of innate immune cell, have gained recognition for their potential in cancer immunotherapy. They recognize lipid antigens presented on the MHC I-like molecule CD1d, representing a unique feature of tumor cells that can be exploited by iNKT cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Run Xiao, Anthony G. Mansour, Wei Huang, Quais N. Hassan, Ryan K. Wilkins, Suraj Komatineni, Rhiannon Bates, Seemaab Ali, Logan A. Chrislip, Nicholas J. Queen, Shoubao Ma, Jianhua Yu, Matthew R. Lordo, Bethany L. Mundy-Bosse, Michael A. Caligiuri, Lei Cao
Summary: Restoring CD1d gene expression in adipocytes leads to T cell expansion and inflammation in adipose tissue, which is associated with dysregulation of adipocyte functional genes and upregulation of apoptotic pathway proteins.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Oncology
Hashem Bayatipoor, Saber Mehdizadeh, Roghayeh Jafarpour, Zeinab Shojaei, Salar Pashangzadeh, Morteza Motallebnezhad
Summary: Natural killer T (NKT) cells are a specific subset of T cells that play a crucial role in anti-tumor immune responses. Different subtypes of NKT cells have varying functions, with some promoting tumor rejection and inhibiting metastasis, while others have an inhibitory and regulatory function. NKT-based immunotherapy has shown promise in cancer treatment, and various approaches, such as manipulating NKT cells through dendritic cells or injection of specific molecules, have been explored.
Article
Cell Biology
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi
Summary: This study found that iNKT cell subsets exhibit differences in various peripheral organs and have unique distributions, especially for iNKT1 cells. The research also revealed the important role of Klf2 in regulating the migration and differentiation of iNKT cells.
Article
Immunology
Hyun Jung Park, Sung Won Lee, Yun Hoo Park, Tae-Cheol Kim, Luc Van Kaer, Seokmann Hong
Summary: Regulatory T cells (Treg) are important for maintaining self-tolerance and preventing immunological diseases. A small population of Treg cells expressing NK1.1 receptors has been found, which exhibit functional characteristics of both NK cells and Treg cells. These NK1.1(+) Treg cells may play a unique regulatory role in inflammatory immune responses such as infection and autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michio Shimamura, Shin-ichi Kamijo, Petr Illarionov
Summary: Helicobacter pylori extracts cholesterol from the host and converts it to its glycosides. It has been found that iNKT cells can recognize the cholesteryl glycosides produced by H. pylori and activate immune responses through a Mincle-dependent pathway. These findings provide insights into the immune mechanisms against H. pylori infection.
Article
Medicine, Research & Experimental
Tina Senff, Christopher Menne, Christine Cosmovici, Lia Laura Lewis-Ximenez, Jasneet Aneja, Ruth Broering, Arthur Y. Kim, Astrid M. Westendorf, Ulf Dittmer, Norbert Scherbaum, Georg M. Lauer, Joerg Timm
Summary: The activation of iNKT cells is closely related to the pathogenesis of hepatitis C virus infection and may be involved in liver damage.
Article
Oncology
Ayaka Hara, Ryo Koyama-Nasu, Mariko Takami, Takahide Toyoda, Takahiro Aoki, Fumie Ihara, Masayoshi Kobayashi, Seiichiro Hirono, Tomoo Matsutani, Toshinori Nakayama, Yasuo Iwadate, Shinichiro Motohashi
Summary: CD1d expression represents a novel target for NKT cell-based immunotherapy for glioblastoma patients, inducing cytotoxicity of CD1d-positive glioblastoma cells by activating iNKT cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Fathihah Basri, Sundo Jung, Se Hoon Park, Se-Ho Park
Summary: In the study of collagen-induced arthritis, it was discovered that the tolerogenicity of pM Phi is conferred by iNKT cells during pM Phi development, rather than by interactions of pM Phi with iNKT cells during antigen presentation to cognate T cells.
Article
Oncology
Bindu Varghese, Lydia Lynch, Lianne E. Vriend, Dobrin Draganov, Justice M. Clark, Haydn T. Kissick, Sharlin Varghese, Martin G. Sanda, Glenn Dranoff, M. Simo Arredouani, Steven P. Balk, Mark A. Exley
Summary: By adding α GC to a tumor cell vaccine, the therapeutic effect against prostate cancer can be enhanced. In a therapeutic model, mice treated with the combination vaccine showed prolonged survival and tumor inhibition. Mechanistic studies revealed that GM-CSF and iNKT cells in the vaccine played a crucial role in anti-tumor immune responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Leo Bertrand, Agnes Lehuen
MOLECULAR METABOLISM
(2019)
Article
Pharmacology & Pharmacy
Li-Long Pan, Wenjie Liang, Zhengnan Ren, Chunqing Li, Yong Chen, Wenying Niu, Xin Fang, Yanyan Liu, Ming Zhang, Julien Diana, Birgitta Agerberth, Jia Sun
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Amine Toubal, Badr Kiaf, Lucie Beaudoin, Lucie Cagninacci, Moez Rhimi, Blandine Fruchet, Jennifer da Silva, Alexandra J. Corbett, Yannick Simoni, Olivier Lantz, Jamie Rossjohn, James McCluskey, Philippe Lesnik, Emmanuelle Maguin, Agnes Lehuen
NATURE COMMUNICATIONS
(2020)
Review
Immunology
Wenjie Liang, Julien Diana
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
William Guesdon, Tiffany Pezier, Sandrine Menard, Alessandra Nicolosi, Yves Le Vern, Anne Silvestre, Julien Diana, Fabrice Laurent, Sonia Lacroix-Lamande
Article
Gastroenterology & Hepatology
Matthieu Rouland, Lucie Beaudoin, Ophelie Rouxel, Leo Bertrand, Lucie Cagninacci, Azadeh Saffarian, Thierry Pedron, Dalale Gueddouri, Sandra Guilmeau, Anne-Francoise Burnol, Latif Rachdi, Asmaa Tazi, Juliette Mouries, Maria Rescigno, Nathalie Vergnolle, Philippe Sansonetti, Ute Christine Rogner, Agnes Lehuen
Summary: Our study found in autoimmune T1D models a consistent decrease in IL-17A, IL-22, and IL-23A in gut mucosa, along with impaired intestinal epithelial cell function and compromised gut integrity. This was accompanied by dysbiosis, including progressive loss of SFB. Anti-inflammatory treatment restored gut mucosa and immune cell function, reducing diabetes incidence.
Article
Biochemistry & Molecular Biology
Amine Toubal, Agnes Lehuen
Summary: MAIT cells are innate-like T cells enriched in mucosal sites and tissues such as adipose tissue and liver, playing a crucial role in immunity against microbial pathogens. Recent research suggests that they may also be involved in metabolic diseases and chronic inflammation, highlighting their importance in disease pathogenesis.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Heloise Flament, Matthieu Rouland, Lucie Beaudoin, Amine Toubal, Leo Bertrand, Samuel Lebourgeois, Camille Rousseau, Pauline Soulard, Zouriatou Gouda, Lucie Cagninacci, Antoine C. Monteiro, Margarita Hurtado-Nedelec, Sandrine Luce, Karine Bailly, Muriel Andrieu, Benjamin Saintpierre, Franck Letourneur, Youenn Jouan, Mustapha Si-Tahar, Thomas Baranek, Christophe Paget, Christian Boitard, Anais Vallet-Pichard, Jean-Francois Gautier, Nadine Ajzenberg, Benjamin Terrier, Frederic Pene, Jade Ghosn, Xavier Lescure, Yazdan Yazdanpanah, Benoit Visseaux, Diane Descamps, Jean-Francois Timsit, Renato C. Monteiro, Agnes Lehuen
Summary: Severe cases of COVID-19 are characterized by immune system dysfunction, particularly a significant reduction and high activation of mucosal-associated invariant T (MAIT) cells. These cells play a crucial role in disease severity and mortality, correlating with the activation of inflammatory cytokines and cytotoxic phenotype.
Review
Immunology
Isabelle Nel, Leo Bertrand, Amine Toubal, Agnes Lehuen
Summary: Mucosal Associated Invariant T (MAIT) cells play an important role in protecting and maintaining mucosal barriers, but may also be involved in immune and inflammatory pathologies affecting these organs.
MUCOSAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Isabelle Nel, Lucie Beaudoin, Zouriatou Gouda, Camille Rousseau, Pauline Soulard, Matthieu Rouland, Leo Bertrand, Christian Boitard, Etienne Larger, Agnes Lehuen
Summary: Alterations in MAIT cell frequency, phenotype, and function were more pronounced in adults with long-term type 1 diabetes compared to those with recent-onset diabetes. There were correlations between MAIT cell variables and clinical characteristics. Additionally, the presence of another autoimmune disease in women with long-term type 1 diabetes exacerbated MAIT cell alterations.
Editorial Material
Immunology
Leo Bertrand, Amine Toubal, Agnes Lehuen
Editorial Material
Medicine, Research & Experimental
Wenjie Liang, Julien Diana
Summary: The study identified a novel antimicrobial peptide from human oral actinomyces, actinomycesin, which showed efficacy and safety against various bacterial strains. This discovery highlights the potential of human oral bacteria as a source of antimicrobial agents in the fight against multidrug-resistant bacteria.
EMBO MOLECULAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Wenjie Liang, Emmanuelle Enee, Cedric Andre-Vallee, Marika Falcone, Jia Sun, Julien Diana
Summary: This study identified a defective colonic expression of the CRAMP antimicrobial peptide as the cause of dysbiosis in newborn NOD mice, leading to pathological immune imprinting and the subsequent development of autoimmune diabetes in adulthood. Increasing colonic CRAMP expression can restore colonic homeostasis and prevent autoimmune diabetes.
Article
Endocrinology & Metabolism
Dalale Gueddouri, Michele Cauzac, Veronique Fauveau, Fadila Benhamed, Wafa Charifi, Lucie Beaudoin, Matthieu Rouland, Florian Sicherre, Agnes Lehuen, Catherine Postic, Gaelle Boudry, Anne-Francoise Burnol, Sandra Guilmeau
Summary: This study demonstrates that acute insulin resistance and hyperglycemia induced by an insulin receptor antagonist in mice can lead to increased gut permeability without systemic inflammatory response. Additionally, this treatment results in gut dysbiosis and defects in gut barrier function, but discontinuation of the treatment can restore gut microbial balance and intestinal barrier integrity promptly.
MOLECULAR METABOLISM
(2022)
Review
Immunology
Amine Toubal, Isabelle Nel, Sophie Lotersztajn, Agnes Lehuen
NATURE REVIEWS IMMUNOLOGY
(2019)