期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 38, 期 11, 页码 2952-2956出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.200838823
关键词
Immunoevasion; Murine CMV; NKG2D
类别
资金
- Croatian Ministry of Science [0621261-1263, 0621261-1268, 0621261-1271]
- HHMI Scholars grant
NKG2D is a potent activating receptor on NK cells and a co-stimulatory receptor on CD8(+) T cells. Through its ability to recognize a panel of ligands inducible by stress or infection, it plays an important role in the control of viral infections. The viruses have evolved robust mechanisms to counteract NKG2D-dependent immune response. The functions of these viral inhibitors are well characterized during the early days post-infection but less so during the chronic viral infection.
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