Article
Oncology
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K. Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M. Conroy, Patricia A. Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R. Teras, Alpa V. Patel, Fergus J. Couch, Janet E. Olson, Elinor J. Sawyer, Rebecca Roylance, Stig E. Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guenel, Therese Truong, Renske Keeman, Marjanka K. Schmidt, Anna H. Wu, Chiu-Chen Tseng, Angela Cox, Simon S. Cross, Irene L. Andrulis, John L. Hopper, Melissa C. Southey, Pei-Ei Wu, Chen-Yang Shen, Peter A. Fasching, Arif B. Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E. Jones, Anthony J. Swerdlow, Reiner Hoppe, Yon-Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M. Hartikainen, Javier Benitez, Anna Gonzalez-Neira, Christopher A. Haiman, Thilo Doerk, Natalia V. Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N. Kristensen, Rob A. E. M. Tollenaar, Bernadette A. M. Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V. Lacey, Maria Elena Martinez, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Keun-Young Yoo, Daehee Kang
Summary: The study focused on gene-environment interactions related to estrogen exposure or metabolism in Korean women, finding two interactions that were not replicated in a larger European and Asian population. This highlights the specificity of breast cancer risk in Koreans.
Review
Pharmacology & Pharmacy
Yuhei Nishimura, Kenji Kurosawa
Summary: This mini-review discusses the interaction between genetic and environmental factors in developmental disorders (DDs) using genome-wide and candidate gene-based approaches. It focuses on zebrafish and mouse models and introduces novel methods for analyzing G x E associated with DDs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Marc G. Weisskopf, Michael Leung
Summary: This study aimed to evaluate the impact of recall bias on the identification of gene-environment interactions when the independence assumption is violated. The results showed that even if gene-environment independence is violated, it is still possible to identify gene-environment interactions by knowing the strength and direction of gene-environment dependence.
Article
Biochemical Research Methods
Xiaoyan Wang, Hongduo Liu, Shuangge Ma
Summary: Gene-environment interactions are important for complex diseases. A recently developed quasi-likelihood + penalization approach is extended to linear, logistic, and Poisson regressions, and implemented in the user-friendly R package GEInfo.
Article
Psychology, Multidisciplinary
Michelle Jin Yee Neoh, Peipei Setoh, Andrea Bizzego, Moses Tandiono, Jia Nee Foo, Albert Lee, Marc H. Bornstein, Gianluca Esposito
Summary: This study investigated how the oxytocin receptor gene (OXTR) genotypes and childcare experience interacted to regulate face categorization in adults. The results showed a significant interaction of genetic group and childcare experience, suggesting an indirect pathway through which genes and experiences interact to shape mature social sensitivity to faces in human adults.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Nutrition & Dietetics
Rasha Shraim, Conor MacDonnchadha, Lauren Vrbanic, Ross McManus, Lina Zgaga
Summary: Vitamin D is crucial for good health and its production is influenced by environmental and personal factors, including genetics. Understanding gene-environment interactions (GxE) is important for determining vitamin D status. This review aimed to examine the methods used in GxE studies on vitamin D and report on the effect estimates. The review included 7 studies and provided recommendations for future GxE research in vitamin D.
Review
Environmental Sciences
Dylan J. Wallis, Lisa Truong, Jane La Du, Robyn L. Tanguay, David M. Reif
Summary: Exposure to endocrine-disrupting chemicals (EDCs) can lead to a variety of disorders by disrupting the complex endocrine signaling pathways that regulate development, physiology, and behavior across the body. The mechanisms of endocrine disruption, such as gene regulation and DNA/protein binding, are linked to differences in individual susceptibility within diverse populations. Research is needed to further understand how gene-environment interactions across these pathways may contribute to differences in susceptibility to EDCs, with a focus on the intricate thyroid pathway.
Article
Biochemical Research Methods
Yan Liu, Yuzhao Gao, Ruiling Fang, Hongyan Cao, Jian Sa, Jianrong Wang, Hongqi Liu, Tong Wang, Yuehua Cui
Summary: Genes interact to fulfill tasks; linear and nonlinear interactions can differ; developing statistical methods to capture underlying mechanisms is crucial.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Genetics & Heredity
Richard H. Finnell, Carlo Donato Caiaffa, Sung-Eun Kim, Yunping Lei, John Steele, Xuanye Cao, Gabriel Tukeman, Ying Linda Lin, Robert M. Cabrera, Bogdan J. Wlodarczyk
Summary: Structural congenital malformations are the leading cause of infant mortality in the United States, with close to 3% of newborns presenting with birth defects. Neural tube defects (NTDs) are among the most prevalent human birth defects, with spinal bifida and encephalocele as major classifications.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Paul T. Williams
Summary: Heritability of IL-6 concentrations is quantile-dependent, showing larger genetic effects in diseases and conditions that elevate IL-6 concentrations compared to unaffected controls.
Article
Genetics & Heredity
Masao Ueki, Gen Tamiya
Summary: The proposed genetic prediction modeling approach extends previous methods to include gene-environment interaction effects, demonstrating superior performance compared to other modeling approaches through simulation studies and real data analysis. The model's ability to simultaneously consider multiple environmental variables and automatically remove irrelevant predictors makes it a valuable tool for GWAS studies.
G3-GENES GENOMES GENETICS
(2021)
Article
Genetics & Heredity
Masao Ueki, Gen Tamiya
Summary: The proposed genetic prediction modeling approach considers both gene effects and gene-environment interaction effects, demonstrating superior performance in simulation studies and practical utility in Alzheimer's Disease genetic data analysis.
G3-GENES GENOMES GENETICS
(2021)
Article
Environmental Sciences
Preethi Thunga, Lisa Truong, Yvonne Rericha, Jane La Du, Mackenzie Morshead, Robyn L. Tanguay, David M. Reif
Summary: Individuals within genetically diverse populations show varying susceptibilities to chemical exposures, and understanding gene-environment interactions is crucial. This study used zebrafish as a model organism to assess the variation in larval behavior and gene expression in different environments, revealing significant GxE effects.
Article
Plant Sciences
Jian-Fang Zuo, Ying Chen, Chao Ge, Jin-Yang Liu, Yuan-Ming Zhang
Summary: This study investigated the effects of environment on seed oil content and fatty acid compositions in soybean through genome-wide association studies. Several oil metabolism genes and gene-by-environment interactions were identified. Co-expression network analysis revealed that these genes, along with drought response genes, may play a significant role in regulating seed oil-related traits. This study provides important insights into the genetic basis and molecular mechanisms underlying seed oil-related traits in soybean, which can aid in soybean breeding.
FRONTIERS IN PLANT SCIENCE
(2022)
