Article
Agriculture, Dairy & Animal Science
Neelam A. Topno, Veerbhan Kesarwani, Sandeep Kumar Kushwaha, Sarwar Azam, Mohammad Kadivella, Ravi Kumar Gandham, Subeer S. Majumdar
Summary: This study explores the variations in milk fat content among cattle breeds at the genetic and transcriptional level. The effect of breed on milk components and the presence of fixed SNP patterns in key genes were identified. Pyrosequencing validated the differences in fat QTLs between high- and low-milk-yielding breeds.
Article
Oncology
Fizzah Abid, Khushbukhat Khan, Yasmin Badshah, Naeem Mahmood Ashraf, Maria Shabbir, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Summary: This study investigated the relationship between PRKCG nsSNPs and structural and functional variations in PKC? in hepatocellular carcinoma. The results suggest that nsSNP rs386134171 may serve as a genetic marker for HCC diagnosis. This study provides a roadmap for future research on HCC.
CANCER CELL INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Somashekhar M. Punnuri, Addissu G. Ayele, Karen R. Harris-Shultz, Joseph E. Knoll, Alisa W. Coffin, Haile K. Tadesse, J. Scott Armstrong, Trahmad K. Wiggins, Hanxia Li, Scott Sattler, Jason G. Wallace
Summary: This study identified genomic regions associated with sorghum aphid resistance through field evaluation and reflectance data analysis. Several common markers were found to be associated with aphid count and plant damage, and loci for reflectance-based traits were identified on different chromosomes. Genes related to sorghum growth and flowering time were also identified. The markers identified in this study will facilitate marker-assisted breeding for sorghum aphid resistance.
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Fisheries
Liyuan Lv, Chenxin Hu, Hongqiang Xu, Jianfen Ren, Biao Wu, Yinghui Dong, Zhihua Lin
Summary: With the development of high-density integrated farming, the razor clam Sinonovacula constricta is facing pressure from environmental factors, especially ammonia nitrogen, which threatens the growth and survival of aquatic animals. To cultivate new strains with ammonia tolerance, the genetic basis underlying ammonia tolerance of S. constricta needs to be comprehensively dissected. In this study, a genome wide association study (GWAS) was performed to identify the single nucleotide polymorphisms (SNPs) and genes associated with ammonia tolerance. The results provide valuable markers for selective breeding of ammonia-tolerant strains in S. constricta.
Article
Agronomy
Hafiz Ghulam Muhu-Din Ahmed, Muhammad Nouman Iqbal, Muhammad Arslan Iqbal, Yawen Zeng, Aziz Ullah, Muhammad Iqbal, Humayun Raza, Muhammad Majid Yar, Nadeem Sarwar, Muhammad Imran, Saddam Hussain
Summary: GWAS was conducted in bread wheat using high-density Illumina 90K Infinium SNP array to determine genetic potential for water shortage tolerance. Significant SNPs associated with stomatal frequency, leaf venation and grain yield under water shortage conditions were identified, highlighting the importance of these traits for drought tolerance in wheat.
Article
Medicine, Research & Experimental
Ching-Lung Ko, Wei-Zhi Lin, Meng-Ting Lee, Yu-Tien Chang, Hung-Che Lin, Yi-Syuan Wu, Jun-Fu Lin, Ke-Ting Pan, Yu-Chuan Chang, Ko-Han Lee, Yi-Lun Lee, Tsung-Ting Hsieh, Jia-Hsin Huang, Chih-Hung Wang, Sung-Sen Yang, Hsiang-Cheng Chen, Chi-Ming Chu
Summary: This study explored the race-specific SNP susceptibility of AS in Taiwanese individuals and found an association between HLA-B27 and AS susceptibility SNPs. The study also found differences in AS SNPs between Taiwanese individuals and other races, and that Taiwanese individuals with HLA-B27 positivity had a higher proportion of minor alleles. Additionally, AS polygenic risk score models were developed and individuals with high polygenic risk had a fivefold increased risk of developing AS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Kafilat Abiodun Odesola, Odunayo Joseph Olawuyi, Rajneesh Paliwal, Olaniyi Ajewole Oyatomi, Michael T. T. Abberton
Summary: This study reveals the associations between sequencing-based diversity array technology (DArTseq) and phenotypic character as well as differing indices related to drought tolerance in 100 accessions of Bambara groundnut. The genome wide association study predicts drought tolerance in Bambara accessions and identifies quantitative trait loci (QTLs) that could be useful in marker-assisted selection in drought molecular breeding programs. The selected drought-tolerant accessions could be used for hybridization breeding.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agronomy
Leila Nayyeripasand, Ghasem Ali Garoosi, Asadollah Ahmadikhah
Summary: This study identified rice genomic regions associated with early stage salinity tolerance and candidate genes using genome-wide association study. The identified genes can be used for improving salinity tolerance in rice breeding programs and further study can help uncover the mechanisms of salinity tolerance at molecular level.
Article
Plant Sciences
Fenglei Sun, Jun Ma, Weijun Shi, Yanlong Yang
Summary: In this study, a genome-wide association study (GWAS) was conducted on 8 traits of 150 cotton germplasms using resequencing data. The results showed that 18 SNPs were significantly correlated with cotton yield traits under drought conditions, while 8 SNPs were significantly correlated with the traits related to yield. Transcriptome data analysis identified four highly expressed genes after drought stress. qRT-PCR confirmed that these genes had the same expression pattern in samples with extreme drought tolerance. This study provides a theoretical basis for genetic analysis and breeding improvement of cotton yield traits under drought stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Daowu Hu, Shoupu He, Gaofei Sun, Yinhua Jia, Yonghong Su, Xiaojing Ma, Washu Dev, Mian Faisal Nazir, Xiaoli Geng, Liru Wang, Zhaoe Pan, Baojun Chen, Hongge Li, Xiaoyang Wang, Baoyin Pang, Xiongming Du
Summary: In this study, a genome-wide association study was conducted on 213 Asian cotton accessions to identify SNPs and genes associated with leaf traits. Differences in leaf morphology and transcriptome between two varieties were analyzed, and two coding genes and two microRNAs were selected as candidate genes for leaf traits.
Article
Genetics & Heredity
Huiyu Wang, Xiaoyi Wang, Mingli Li, Hao Sun, Qiang Chen, Dawei Yan, Xinxing Dong, Yuchun Pan, Shaoxiong Lu
Summary: This study conducted a genome-wide association study using SLAF-seq technology to identify candidate genes and novel QTLs related to growth traits in pigs, revealing the genetic mechanisms underlying pig growth traits and providing a biological basis for improving pig growth and production performance.
Article
Biotechnology & Applied Microbiology
Lin Liu, Lu-Guang Jiang, Jin-Hong Luo, Ai-Ai Xia, Li-Qun Chen, Yan He
Summary: This study investigated the phenotypic diversity and genetic basis of root hair length in maize using a diverse association panel. Through GWAS analysis, candidate genes related to cellular signaling, polar growth, disease resistance, and metabolic pathways were identified, shedding light on the genetic mechanisms underlying root hair growth in maize.
Article
Multidisciplinary Sciences
Ishtiaque Ahammad, Tabassum Binte Jamal, Arittra Bhattacharjee, Zeshan Mahmud Chowdhury, Suparna Rahman, Md Rakibul Hassan, Mohammad Uzzal Hossain, Keshob Chandra Das, Chaman Ara Keya, Md Salimullah
Summary: GRIN2A is a gene encoding NMDA receptors in the central nervous system, playing a crucial role in synaptic transmission, plasticity, and excitotoxicity. Variants in this gene, particularly the I463S variant, are predicted to have deleterious effects on protein structure and function. Bioinformatics tools were used to assess the impact of these variants, providing valuable insights for future research on GRIN2A-related diseases.
Article
Genetics & Heredity
Zhuliang Yang, Leqin Zou, Tiantian Sun, Wenwen Xu, Linghu Zeng, Yinhai Jia, Jianping Jiang, Jixian Deng, Xiurong Yang
Summary: This study identified SNPs and INDELs associated with comb traits in Nandan-Yao chickens through GWAS, revealing a significant region on chromosome 6 and candidate genes such as FGFR2 and CYB5R2. These findings could accelerate genetic improvement of comb development through marker-assisted breeding.
FRONTIERS IN GENETICS
(2021)
Article
Peripheral Vascular Disease
Geng Wang, Laxmi Bhatta, Gunn-Helen Moen, Liang-Dar Hwang, John P. Kemp, Tom A. Bond, Bjorn Olav Asvold, Ben Brumpton, David M. Evans, Nicole M. Warrington
Summary: This study used a Mendelian randomization framework to examine the relationship between maternal blood pressure during pregnancy and offspring cardiometabolic disease. The results suggest that there is little evidence to support a causal relationship between maternal blood pressure and adverse cardiometabolic outcomes in offspring.
Article
Environmental Studies
David M. Evans, Peter Jackson, Monica Truninger, Joao A. Baptista
Summary: This paper discusses the importance of freshness in food systems and identifies four enactments of freshness through extensive fieldwork in the UK and Portugal. The analysis focuses on plastic food packaging and uses these enactments to consider questions about realities and relationships. The authors argue that freshness is a suitable focus for creating hybrid forums to debate future possibilities and suggest that attention to the multiple ontologies of qualities complements discussions of ontological politics.
ENVIRONMENT AND PLANNING A-ECONOMY AND SPACE
(2022)
Article
Genetics & Heredity
Laurence J. Howe, Michel G. Nivard, Tim T. Morris, Ailin F. Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Rafael Ahlskog, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M. Ratliff, Lawrence F. Bielak, Marianne Nygaard, Alexandros Giannelis, Emily A. Willoughby, Chandra A. Reynolds, Jared V. Balbona, Ole A. Andreassen, Helga Ask, Aris Baras, Christopher R. Bauer, Dorret I. Boomsma, Archie Campbell, Harry Campbell, Zhengming Chen, Paraskevi Christofidou, Elizabeth Corfield, Christina C. Dahm, Deepika R. Dokuru, Luke M. Evans, Eco J. C. de Geus, Sudheer Giddaluru, Scott D. Gordon, K. Paige Harden, W. David Hill, Amanda Hughes, Shona M. Kerr, Yongkang Kim, Hyeokmoon Kweon, Antti Latvala, Deborah A. Lawlor, Liming Li, Kuang Lin, Per Magnus, Patrik K. E. Magnusson, Travis T. Mallard, Pekka Martikainen, Melinda C. Mills, Pal Rasmus Njolstad, John D. Overton, Nancy L. Pedersen, David J. Porteous, Jeffrey Reid, Karri Silventoinen, Melissa C. Southey, Camilla Stoltenberg, Elliot M. Tucker-Drob, Margaret J. Wright, Hyeokmoon Kweon, John K. Hewitt, Matthew C. Keller, Michael C. Stallings, James J. Lee, Kaare Christensen, Sharon L. R. Kardia, Patricia A. Peyser, Jennifer A. Smith, James F. Wilson, John L. Hopper, Sara Hagg, Tim D. Spector, Jean-Baptiste Pingault, Robert Plomin, Alexandra Havdahl, Meike Bartels, Nicholas G. Martin, Sven Oskarsson, Anne E. Justice, Iona Y. Millwood, Kristian Hveem, Oyvind Naess, Cristen J. Willer, Bjorn Olav Asvold, Philipp D. Koellinger, Jaakko Kaprio, Sarah E. Medland, Robin G. Walters, Daniel J. Benjamin, Patrick Turley, David M. Evans, George Davey Smith, Caroline Hayward, Ben Brumpton, Gibran Hemani, Neil M. Davies
Summary: Estimates from genome-wide association studies (GWAS) can be influenced by inherited variation, population stratification, and indirect genetic effects. This study combines data from 178,086 siblings to generate population and within-family GWAS estimates for 25 phenotypes. The within-family estimates are smaller than population estimates for certain phenotypes and show differences in genetic correlations and Mendelian randomization analyses.
Article
Multidisciplinary Sciences
Veronika V. Odintsova, Matthew Suderman, Fiona A. Hagenbeek, Doretta Caramaschi, Jouke-Jan Hottenga, Rene Pool, Conor V. Dolan, Lannie Ligthart, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Eco J. C. de Geus, Jeffrey J. Beck, Erik A. Ehli, Gabriel Cuellar-Partida, David M. Evans, Sarah E. Medland, Caroline L. Relton, Dorret I. Boomsma, Jenny van Dongen
Summary: This study investigated the epigenetic mechanisms of handedness and found that CpG sites located near handedness-associated genetic variants were more strongly associated with left-handedness. However, no differentially methylated positions were identified. Longitudinal analyses demonstrated moderately stable associations across age but inconsistency across tissues.
SCIENTIFIC REPORTS
(2022)
Article
Geography
Damian Maye, Ben Coles, David Evans
Summary: The Anthropocene is a useful framework for understanding human-environment processes, particularly in relation to food and farming. Despite its importance, there is a lack of focus on the Anthropocene in recent developments in food geography. This article aims to address this by connecting and integrating social science scholarship on food geographies 'in,' 'of,' and 'for' the Anthropocene.
GEOGRAPHICAL JOURNAL
(2022)
Article
Behavioral Sciences
Gunn-Helen Moen, Michel Nivard, Laxmi Bhatta, Nicole M. Warrington, Cristen Willer, Bjorn Olav Asvold, Ben Brumpton, David M. Evans
Summary: This study introduces a new statistical model using the genomic SEM software to partition the genetic covariation between birthweight and cardiometabolic traits into maternally mediated and offspring mediated contributions. The results show some evidence for maternally mediated effects of systolic blood pressure on offspring birthweight and pleiotropy between birthweight and non-fasting glucose mediated through the offspring genome.
Article
Public, Environmental & Occupational Health
Geng Wang, Tom A. Bond, Nicole M. Warrington, David M. Evans
Summary: This study used a discordant twin study design to investigate the association between birth weight and later-life cardiometabolic risk factors. The results showed that there was no strong evidence of association between within-pair differences in birth weight and most cardiometabolic risk factors in MZ twins, except for nominal associations with C-reactive protein and insulin-like growth factor 1.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Christine Sommer, Kjersti G. Vangberg, Gunn-Helen Moen, David M. Evans, Sindre Lee-Odegard, Ingvild K. Blom-Hogestol, Line Sletner, Anne K. Jenum, Christian A. Drevon, Hanne L. Gulseth, Kare Birkeland
Summary: This study investigates the influence of glucose, insulin, body fat, BMI, food intake, and physical activity on serum sOb-R levels. The researchers found that BMI and insulin were causally linked to decreased sOb-R levels, while intensive exercise and food intake acutely increased sOb-R levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Genetics & Heredity
Zhixiu Li, Allan F. F. McRae, Geng Wang, Jonathan J. J. Ellis, Jessica Whyte, Tony J. J. Kenna, Matthew A. A. Brown, David M. M. Evans
Article
Medicine, General & Internal
Jian Zhao, Isobel D. Stewart, Denis Baird, Dan Mason, John Wright, Jie Zheng, Tom R. Gaunt, David M. Evans, Rachel M. Freathy, Claudia Langenberg, Nicole M. Warrington, Deborah A. Lawlor, Maria Carolina Borges
Summary: This study used two-sample Mendelian randomisation to explore the effect of maternal circulating amino acids on fetal growth. The results indicate that increased levels of maternal glutamine and serine are associated with higher birthweight, while increased levels of leucine and phenylalanine are associated with lower birthweight.
Article
Geography
Jonathan D. Beacham, David M. Evans
Summary: The adverse consequences of contemporary agri-food relations have resulted in calls for fundamental systemic change. This article revisits debates from two decades ago and argues that integrating consumption into agri-food scholarship is crucial in the current context. The article suggests that recent advances in consumption studies and shifts in food politics offer potential for renewing perspectives on production and consumption.
SOCIOLOGIA RURALIS
(2023)
Article
Public, Environmental & Occupational Health
Laurence J. Howe, Humaira Rasheed, Paul R. Jones, Dorret Boomsma, David M. Evans, Alexandros Giannelis, Caroline Hayward, John L. Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A. Lind, Nicholas G. Martin, Pekka Martikainen, Sarah E. Medland, Tim T. Morris, Michel G. Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A. Smith, Emily A. Willoughby, James F. Wilson, Bjorn Olav Asvold, Oyvind E. Naess, George Davey Smith, Jaakko Kaprio, Ben Brumpton, Neil M. Davies
Summary: Previous Mendelian randomization (MR) studies suggest that educational attainment has beneficial effects on adult health outcomes. However, these estimates may be biased due to population stratification, assortative mating, and indirect genetic effects. Using both population and within-sibship MR approaches, this study provides evidence that genetic liability to educational attainment is associated with decreased BMI, cigarette smoking, and SBP, and potentially with mortality.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Psychiatry
Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pal R. Njolstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafo, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Summary: Parental genes can influence offspring psychiatric outcomes indirectly through the environment they create. This study aimed to estimate the contribution of parental genetic nurture effects on childhood psychiatric symptoms using advanced statistical genetic methods. The results suggest that parental genetic nurture effects may play a role in explaining individual differences in childhood psychiatric symptoms, but further research with larger samples is needed.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Sociology
David M. Evans, Nicky Gregson
Summary: This article argues for a reorientation of the sociology of consumption towards a financial and monetary perspective. It highlights the neglect of the rise of financialised capitalism in the field and suggests that the current conditions of consumption make it untenable to ignore money. The article offers an explanation for the absence of money in the sociology of consumption, reinterprets previous studies through the lens of money and finance, and indicates future research priorities and pathways for a reorientated sociology of consumption.
SOCIOLOGY-THE JOURNAL OF THE BRITISH SOCIOLOGICAL ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Geng Wang, Nicole M. Warrington, David M. Evans
Summary: The study utilizes structural equation modeling (SEM) to estimate the maternal and fetal effects of classical HLA alleles on birthweight (BW). Results show that the model generates unbiased estimates, appropriate type I error rates, and sufficient power to detect allelic effects on BW. New allelic associations between BW and classical HLA alleles provide insights into the immunogenetics of fetal growth in utero.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)