期刊
EUROPEAN JOURNAL OF HUMAN GENETICS
卷 16, 期 5, 页码 626-634出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ejhg.5201999
关键词
delinquency; crime; violence; MAOA; genotype; antisocial behavior
资金
- NICHD NIH HHS [R03 HD042490, R24 HD050924, P01 HD031921, R03 HD042490-02, R03 HD053385, P01 HD031921-050005, P01-HD31921, R03 HD053385-01] Funding Source: Medline
Genetic studies of delinquent and criminal behavior are rare in spite of the wide recognition that individuals may differ in their propensity for delinquency and criminality. Using 2524 participants in Add Health in the United States, the present study demonstrates a link between the rare 2 repeat of the 30-bp VNTR in the MAOA gene and much higher levels of self- reported serious and violent delinquency. The evidence is based on a statistical association analysis and a functional analysis of MAOA promoter activity using two human brain- derived cell lines: neuroblastoma SH- SY5Y and human glioblastoma 1242-MG. The association analysis shows that men with a 2R report a level of serious delinquency and violent delinquency in adolescence and young adulthood that were about twice ( CI: ( 0.21, 3.24), P = 0.025; and CI: ( 0.37, 2.5), P = 0.008 for serious and violent delinquency, respectively) as high as those for participants with the other variants. The results for women are similar, but weaker. In the functional analysis, the 2 repeat exhibits much lower levels of promoter activity than the 3 or 4 repeat.
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