期刊
EUROPEAN JOURNAL OF HISTOCHEMISTRY
卷 62, 期 3, 页码 253-256出版社
PAGEPRESS PUBL
DOI: 10.4081/ejh.2018.2969
关键词
Ozone; stem cells; adipogenesis; microscopy
类别
资金
- University of Verona
- Doctoral Program Nanoscience and Advanced Technologies of the University of Verona
Ozone is a strong oxidant, highly unstable atmospheric gas. Its medical use at low concentrations has been progressively increasing as an alternative/adjuvant treatment for several diseases. In this study, we investigated the effects of mild ozonisation on human adipose-derived adult stem (hADAS) cells i.e., mesenchymal stem cells occurring in the stromal-vascular fraction of the fat tissue and involved in the tissue regeneration processes. hADAS cells were induced to differentiate into the adipoblastic lineage, and the effect of low ozone concentrations on the adipogenic process was studied by combining histochemical, morphometric and ultrastructural analyses. Our results demonstrate that ozone treatment promotes lipid accumulation in hADAS cells without inducing deleterious effects, thus paving the way to future studies aimed at elucidating the effect of mild ozonisation on adipose tissue for tissue regeneration and engineering.
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