Review
Biochemistry & Molecular Biology
William H. Walker, Paul S. Cooke
Summary: Steroid hormones can diffuse through cell membranes and bind with intracellular receptors to regulate physiological processes. Mouse models have been used to study the regulation of testis and reproductive tract processes by androgens, estrogens, and glucocorticoids. These models have provided important insights into the molecular mechanisms of steroid hormone regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Alev Selek, Zehra Seda Unal Halbutogullari, Cigdem Inci Aydemir, Berrin Cetinarslan, Zeynep Canturk, Ilhan Tarkun, Gulay Erman, Cansu Subasi, Karaoz Erdal
Summary: This study investigates the potential of using an aromatase inhibitor as a substitute for testosterone in treating prolactinomas. The findings reveal that the aromatase inhibitor can inhibit cell proliferation and induce apoptosis in prolactinoma cells, as well as reduce prolactin and estrogen levels.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Environmental Sciences
Bethsaida Cardona, Ruthann A. Rudel
Summary: The study identified hundreds of chemicals that increase the synthesis of estrogen and progesterone, some of which may have carcinogenic or reproductive/developmental toxicity. While some of these chemicals showed effects consistent with this mechanism in vivo studies, many chemicals lacked sufficient in vivo data to evaluate their effects accurately.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Chemistry, Medicinal
Nicholas A. Young, Jeffrey Hampton, Juhi Sharma, Kyle Jablonski, Courtney DeVries, Anna Bratasz, Lai-Chu Wu, Maryam Lustberg, Raquel Reinbolt, Wael N. Jarjour
Summary: Aromatase inhibitors block estrogen production and improve survival in hormone-receptor-positive breast cancer patients, but can also induce joint inflammation (AIIA). A study using a novel animal model found that AIIA is characterized by enhanced NF kappa B activation and inflammation in the joints and surrounding tissue. The findings suggest that AIIA pathogenesis may not be mediated by estrogen deficiency, as previously hypothesized.
Article
Biochemistry & Molecular Biology
Diana Kata, Ilona Grof, Zsofia Hoyk, Eszter Ducza, Maria A. Deli, Istvan Zupko, Imre Foldesi
Summary: In this study, a complex fluorescent immunocytochemical analysis revealed the colocalization of aromatase with the nuclear stain in GFAP-positive astrocytes in cell cultures and adult rat brain, suggesting a unique mechanism in astrocytes that may regulate certain CNS functions via estradiol production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Laura Moutard, Caroline Goudin, Catherine Jaeger, Celine Duparc, Estelle Louiset, Tony Pereira, Francois Fraissinet, Marion Delessard, Justine Saulnier, Aurelie Rives-Feraille, Christelle Delalande, Herve Lefebvre, Nathalie Rives, Ludovic Dumont, Christine Rondanino
Summary: This study investigates steroidogenesis and steroid signaling in organotypic cultures of prepubertal testicular tissues. The results show that there is a failure in the development of adult Leydig cells and altered steroid production and signaling in tissue cultures. Further improvements are needed before the organotypic culture system can be translated into clinics for childhood cancer survivors.
Article
Neurosciences
Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H. Colledge, Erik Hrabovszky, Ulrich Boehm
Summary: Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain, with a network of aromatase neurons identified in the hypothalamus and amygdala. By birth, this network becomes sexually dimorphic, with aromatase neurons in the arcuate nucleus converting testosterone to estrogen to regulate kisspeptin neuron activity. The study highlights a novel mechanism whereby aromatase neurons regulate the activity of distinct neuronal populations expressing estrogen receptors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Lilan Xin, Jian Min, Hebing Hu, Yuanyuan Li, Chuanqian Du, Baohua Xie, Yan Cheng, Xiaofei Deng, Xiangping Deng, Kang Shen, Jian Huang, Chun -Chi Chen, Rey-Ting Guo, Chune Dong, Hai -Bing Zhou
Summary: In this study, a novel class of dual-targeting selective estrogen receptor degraders (SERDs) based on a three-dimensional oxabicycloheptene sulfonamide (OBHSA) scaffold equipped with aromatase inhibitor (AI) activity were identified. These compounds showed excellent ERa degradation activity, ARO inhibitory activity, and antiproliferative activity against drug-resistant breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Jiewei Hu, Yuanyuan Huang, Fujia Gao, Wuxiang Sun, Huiyu Liu, Haoran Ma, Tao Yuan, Zixuan Liu, Lei Tang, Yuxuan Ma, Xin Zhang, Jing Bai, Ruimin Wang
Summary: Brain-derived estrogen is an endogenous neuroprotective agent that plays a critical role in maintaining healthy brain function in older individuals, possibly involving GPR30. The synthesis of estrogen is more active in the healthy aged brain, indicated by high levels of aromatase expression. Aromatase knockout in forebrain neurons impairs cognitive function in aged rats, and the expression of estrogen nuclear receptors shows opposite changes during aging.
NEUROBIOLOGY OF AGING
(2023)
Article
Food Science & Technology
Chia -Chien Hsieh, Chi-Hao Wu, Shih-Han Peng, Chia-Hsin Chang
Summary: This study aims to explore the chemopreventive mechanisms of lunasin through inflammatory mediators and estrogen-related molecules in breast cancer cells. The results showed that lunasin inhibited breast cancer cell growth by regulating inflammatory, angiogenic, and estrogen-related molecules, suggesting that lunasin is a promising chemopreventive agent.
FOOD & NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Patricia H. A. Bezerra, Cristina Amaral, Cristina F. F. Almeida, Georgina Correia-da-Silva, Maria Regina Torqueti, Natercia Teixeira
Summary: The third-generation aromatase inhibitors (AIs) are commonly used for treating estrogen receptor-positive breast cancer. However, drug resistance limits their effectiveness. This study found that combining genistein with exemestane can enhance the anticancer properties and increase the antiproliferative effect and apoptosis.
Article
Oncology
Cristina Ferreira Almeida, Natercia Teixeira, Maria Joao Valente, Anne Marie Vinggaard, Georgina Correia-da-Silva, Cristina Amaral
Summary: Estrogen receptor-positive (ER+) breast cancer accounts for 70-85% of cases and combining CBD with aromatase inhibitors (AIs) may improve treatment effectiveness. CBD potentiates the anti-tumor effects of exemestane (Exe) by modulating cell death and specific targets such as ERa and AR. This study highlights the potential benefits of combining CBD with Exe and suggests new therapeutic approaches using cannabinoids.
Article
Biochemistry & Molecular Biology
Fangyan Meng, Xueyun Li, Jingjing Li, Yang Zhu, Ming Su, Bingru Zhang, Yiyan Wang, Ren-shan Ge
Summary: The study found that BPFL has detrimental effects on Leydig cell development in male rats during puberty. BPFL reduces testosterone levels and increases luteinizing hormone and follicle-stimulating hormone levels. Additionally, BPFL increases Leydig cell proliferation but inhibits maturation by blocking androgen receptor and activating estrogen receptor alpha.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Gorowska-Wojtowicz, Michal Duliban, Malgorzata Kotula-Balak, Barbara Bilinska
Summary: This study evaluates the effects of estradiol and its agonists and antagonists on gene expression in mouse testis explants and tumor Leydig cells. The results show that balanced estrogen level and proper GPER and PPAR signaling are crucial for maintaining testis homeostasis, and changes in TGF-beta and COX-2 expressions after estradiol treatment may be involved in testicular tumorigenesis.
Article
Biology
Jing Xu, Jing Bai, Fujia Gao, Chao Xu, Yuanyuan Huang, Danyang Li, Lu Wang, Ruimin Wang
Summary: The study explores the role of G-protein-coupled estrogen receptor 1 (GPER1) signaling in regulating the early inflammatory process after global cerebral ischemia. The findings suggest that GPER1 signaling reduces pro-inflammatory signals and enhances anti-inflammatory signals in the brain. Brain-derived estrogen is found to mediate the anti-inflammatory effects of GPER1 signaling. Understanding the early-stage regulation of inflammation after global cerebral ischemia could lead to improved therapies for brain protection and outcomes.