Article
Cardiac & Cardiovascular Systems
Keisuke Fukuda, Seiji Hasegawa, Tomonori Kawamura, Naoto Waratani, Kumiko Hirata, Akihiro Higashimori, Yoshiaki Yokoi
Summary: This study evaluated the impact of MitraClip therapy on cardiac sympathetic nerve activity in patients with mitral regurgitation. Results showed that MitraClip therapy improved CSN activity, particularly in terms of washout rate, in patients with 3+ or 4+ MR after 6 months.
Article
Medicine, General & Internal
Hiroaki Fujita, Keitaro Ogaki, Tomohiko Shiina, Hiroki Onuma, Hirotaka Sakuramoto, Katsuya Satoh, Keisuke Suzuki
Summary: CJD with a V180I mutation is the most common form of genetic CJD in Japan. This case report highlights the importance of considering CJD in patients presenting with parkinsonism and cardiac sympathetic nerve denervation, even without a family history of CJD. The reduced uptake of cardiac MIBG scintigraphy in these patients cannot confirm a diagnosis of PD, and further evaluation for genetic CJD should be pursued.
Article
Cardiac & Cardiovascular Systems
Satomi Imanari, Yasuhiro Tomita, Satoshi Kasagi, Fusae Kawana, Yuka Kimura, Sugao Ishiwata, Koji Narui, Takatoshi Kasai
Summary: The study found a modest correlation between AHI determined by the ASV device AutoSet CS (ASC) and that calculated by polysomnography (PSG) in patients with HF and SDB. However, the ASC device tended to overestimate AHI and showed moderate agreement with PSG results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Sang-Won Yoo, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim
Summary: This study aimed to explore subtypes of early Parkinson's disease (PD) patients with cardiac sympathetic denervation and their characteristics. The results showed an association between cardiac denervation subtypes and presynaptic dopamine transporter densities in PD patients. The study also observed an association between cardiac catecholamine capacity and cognition in PD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alberto A. Zambon, Federica Trucco, Aidan Laverty, Mollie Riley, Deborah Ridout, Adnan Y. Manzur, Francois Abel, Francesco Muntoni
Summary: This study aimed to investigate the prevalence and features of sleep disordered breathing (SDB) in pediatric patients with Duchenne muscular dystrophy (DMD) and explore the relationship between lung function and sleep abnormalities. The results showed a correlation between forced vital capacity (FVC) and the presence of nocturnal hypoventilation (NH). Additionally, some patients exhibited NH despite having FVC > 50%. These findings have important implications for the clinical management of SDB.
Article
Clinical Neurology
Leonie Kolb, Michael Arzt, Stefan Stadler, Katharina Heider, Lars S. Maier, Maximilian Malfertheiner
Summary: Early ASV usage predicts late ASV usage. In addition, low slow wave sleep before ASV initiation and subjective benefit from ASV may contribute to higher late ASV usage.
SLEEP AND BREATHING
(2021)
Article
Health Care Sciences & Services
Philipp S. Lange, Christian Wenning, Nemanja Avramovic, Patrick Leitz, Robert Larbig, Gerrit Frommeyer, Michael Schaefers, Lars Eckardt
Summary: The study demonstrated that PVI leads to novel defects in cardiac sympathetic innervation, potentially influencing the maintenance of sinus rhythm. Differences in cardiac sympathetic innervation remodeling following PVI, as identified through SPECT analysis, may help predict AF recurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Chemistry, Medicinal
Derk O. Verschure, Kenichi Nakajima, Hein J. Verberne
Summary: Cardiac sympathetic upregulation plays an important role in chronic heart failure. Cardiac I-123-mIBG scintigraphy is a feasible technique for evaluating cardiac sympathetic innervation and has been extensively studied in ischemic and non-ischemic CHF. It has the potential to evaluate prognosis and optimize patient selection for implantable devices such as ICD and CRT.
Review
Pediatrics
Ambika G. Chidambaram, Sanjay Jhawar, Craig M. McDonald, Kiran Nandalike
Summary: Sleep disordered breathing (SDB) is more prevalent in children with neuromuscular diseases (NMD) compared to the general population. It can manifest as various sleep-related problems, depending on the severity of neuromuscular weakness. In-lab diagnostic polysomnography (PSG) remains the gold standard for diagnosis, but poses challenges. Untreated SDB can lead to significant morbidity and mortality.
Article
Clinical Neurology
Thomas J. Dye, Sumalee Hantragool, Christopher Carosella, Guixia Huang, Md M. Hossain, Narong Simakajornboon
Summary: This study retrospectively reviewed the sleep disordered breathing in children receiving VNS therapy, and found that OSA and hypoventilation were relatively common in this population. Management mainly involves positive airway pressure therapy and upper airway surgeries.
Article
Neurosciences
Joachim Brumberg, Anastasia Kuzkina, Constantin Lapa, Sona Mammadova, Andreas Buck, Jens Volkmann, Claudia Sommer, Ioannis U. Isaias, Kathrin Doppler
Summary: Pathological aggregates of alpha-synuclein can be detected in peripheral dermal nerve fibers of patients with idiopathic Parkinson's disease and multiple system atrophy, indicating overlapping pathophysiological mechanisms between the two diseases and suggesting that alpha-synuclein may contribute to cardiac sympathetic neurons impairment in patients with synucleinopathies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Jackie Chiang, Lena Xiao, Elisa Nigro, Aaron St-Laurent, Lauren Weinstock, Eugenia Law, Joanna Janevski, Sarah Kuyntjes, Nisha Cithiravel, Tuyen Tran, Nikolaus E. Wolter, Hernan Gonorazky, Reshma Amin
Summary: This study retrospectively investigated sleep disordered breathing in infants with spinal muscular atrophy (SMA) who received gene replacement therapy. The results showed improvement in sleep disordered breathing after treatment. However, the clinical significance of abnormal polysomnogram parameters for children without sleep disordered breathing or neuromuscular weakness remains unclear.
Article
Medicine, General & Internal
Leonardo Bencivenga, Klara Komici, Stefania Paolillo, Carmela Nappi, Paola Gargiulo, Roberta Assante, Giuseppina Gambino, Fabio Santillo, Grazia Daniela Femminella, Grazia Maria Corbi, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone-Filardi, Giuseppe Rengo
Summary: The study found a weak association between cardiac sympathetic innervation and risk scores for predicting mortality in patients with heart failure. Therefore, it is recommended to integrate tools indicative of both arrhythmic and general mortality risks when evaluating patients eligible for device implantation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Becky X. Lou, Harly Greenberg, Maksim Korotun
Summary: Sleep-disordered breathing, including obstructive sleep apnea and central sleep apnea, affects millions worldwide with significant morbidity and mortality. While PAP therapy has been the gold standard, difficulties with adherence exist. Emerging technologies like hypoglossal nerve stimulator and phrenic nerve stimulator offer new options for improving treatment outcomes.
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Leonardo Bencivenga, Klara Komici, Grazia Daniela Femminella, Stefania Paolillo, Paola Gargiulo, Roberto Formisano, Roberta Assante, Carmela Nappi, Brunella Puzone, Immacolata Sepe, Antonio Cittadini, Dino Franco Vitale, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone Filardi, Giuseppe Rengo
Summary: In this study, the impact of the number of comorbidities on cardiac adrenergic innervation in patients with systolic heart failure was evaluated. It was found that highly comorbid patients had reduced late heart to mediastinum ratio. However, multiple regression analysis showed that the number of comorbidities was not associated with mIBG parameters of cardiac denervation, which were correlated with age, body mass index and left ventricular ejection fraction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)