Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Pharmacology & Pharmacy
Sulin Zheng, Min Qiu, Jason H. Y. Wu, Xiong-fei Pan, Xiong Liu, Lichang Sun, Hailan Zhu, Jiandi Wu, Yuli Huang
Summary: This study found that high LC n-3 PUFA concentrations, measured through dietary intake or circulating biomarkers, are associated with a lower risk of developing HF.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
James H. J. O'Keefe, Evan L. O'Keefe, Carl J. Lavie
Summary: Impressive scientific evidence supports the use of omega-3 in the treatment and prevention of heart failure. The GISSI-HF trial showed that omega-3 can reduce the rate of death or hospitalization for cardiovascular reasons, as well as overall mortality, in patients with heart failure. This benefit was consistent across different subgroups.
JACC-HEART FAILURE
(2022)
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Biochemistry & Molecular Biology
Claudia Sanfilippo, Angela Patti
Summary: The biocatalytic epoxidation of ethanolamides of omega-3 fatty acids EPA and DHA was investigated in the presence of a peroxygenase-containing preparation from oat flour. Good regio- and steroselectivity were observed, and acetone as cosolvent improved the concentration of starting substrates and selectivity in the epoxidation of DHA-EA. This method offers a valuable strategy for obtaining oxyfunctionalized derivatives of fatty acids due to the easy availability of the enzymatic preparation.
BIOORGANIC CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Flavia M. S. De Branco, Ana Elisa M. Rinaldi, Jaqueline L. Pereira, Hamilton Roschel, Catarina M. Azeredo, Erick P. De Oliveira
Summary: This study evaluated the association between plasma omega-3 (6)-3 fatty acids and appendicular muscle mass index (AMMI) in adults, taking into account protein intake. The results showed a positive correlation between plasma omega-3 (6)-3 fatty acids and AMMI in individuals with low protein intake, indicating potential benefits of omega-3 (6)-3 fatty acid supplementation for muscle mass when protein intake is inadequate.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Qi Sun, Ning Gao, Weiliang Xia
Summary: This study found a negative correlation between omega-3 and omega-6 levels and the risk of cholelithiasis. Individuals with low serum omega-3/6 levels should be aware of the risk of cholelithiasis.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Myroslav Sprynskyy, Fernanda Monedeiro, Maciej Monedeiro-Milanowski, Zuzanna Nowak, Aneta Krakowska-Sieprawska, Pawel Pomastowski, Renata Gadzala-Kopciuch, Boguslaw Buszewski
Summary: This study aimed to isolate EPA and DHA from diatom biomass using different extraction methods and analyze the extracts. Reflux extraction yielded the highest content of omega-3 fatty acids, while the extracts obtained from SFE had lower toxicity and could be directly used for product development.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Respiratory System
Patrick Levy, Matthew T. Naughton, Renaud Tamisier, Martin R. Cowie, T. Douglas Bradley
Summary: Heart failure and sleep disordered breathing often coexist and can lead to myocardial damage and worse prognosis in patients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Edith L. Posada-Martinez, Zachary L. Cox, Mariana M. Cano-Nieto, Nikein D. Ibarra-Marquez, Julieta Moreno-Villagomez, Pedro Gudino-Bravo, Jose A. Arias-Godinez, Salvador Lopez-Gil, Magdalena Madero, Veena S. Rao, Alexandre Mebazaa, Daniel Burkhoff, Martin R. Cowie, Marat Fudim, Kevin Damman, Barry A. Borlaug, Jeffrey M. Testani, Juan B. Ivey-Miranda
Summary: In this study, we compared changes in inferior vena cava diameter (IVCD) with venous pressure during ultrafiltration in patients with cardiac dysfunction. The results showed that IVCD tracked changes in volume status and hemoconcentration better than venous pressure, suggesting that IVCD is a more accurate indicator for monitoring the management of heart failure patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Alex Bottle, Roger Newson, Puji Faitna, Benedict Hayhoe, Martin R. Cowie
Summary: This study aimed to explore risk prediction models for heart failure based on general practitioners' electronic health records and compare the data from two different cohorts. The results showed that the survival rates were similar in different years, but the later population was older, frailer, and had more comorbidities. The study also found consistent predictors including age, sex, blood pressure, body mass index, GP visits before diagnosis, and some comorbidities.
Article
Cardiac & Cardiovascular Systems
Ewa A. Jankowska, Peter P. Liu, Martin R. Cowie, Max Groenhart, Kelly D. Cobey, Jonathan Howlett, Michel Komajda, Lars H. Lund, Jose Antonio Magana Serrano, Ricardo Mourilhe-Rocha, Giuseppe M. C. Rosano, Clara Saldarriaga, Pedro V. Schwartzmann, Faiez Zannad, Jian Zhang, Yuhui Zhang, Andrew J. S. Coats
Summary: As part of the REWOLUTION HF programme, two international surveys were conducted to assess the educational needs of healthcare professionals (HCPs) and patients' perspectives on the care of heart failure (HF). The surveys revealed that most HCPs prioritize rapid initiation of guideline-mandated medications and discuss treatment goals with patients. There was good agreement between HCPs and patients on key treatment goals, although HCPs placed greater emphasis on reducing hospitalizations. Patients expressed a desire for more information about HF and its consequences, prognosis, and treatments.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Arvind Singhal, Jillian P. Riley, Martin R. Cowie
Summary: Prior to the Covid-19 pandemic, heart failure (HF) disease management programmes were predominantly in-person, but the pandemic necessitated a shift to teleconsultations. Telemedicine consultations were found to be more convenient for patients, saved them time, and were generally acceptable to clinicians. However, it also brought changes to workflows, consultation dynamics, and clinical assessment methods.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Philip Moons, Tone M. Norekval, Elena Arbelo, Britt Borregaard, Barbara Casadei, Bernard Cosyns, Martin R. Cowie, Donna Fitzsimons, Alan G. Fraser, Tiny Jaarsma, Paulus Kirchhof, Josepa Mauri, Richard Mindham, Julie Sanders, Francois Schiele, Aleksandra Torbica, Ann Dorthe Zwisler
Summary: Patient-reported outcomes (PROs) play a crucial role in understanding patients' perspectives on their health and medical conditions. Their use can lead to improvements in healthcare quality and informed clinical decisions. This article provides an overview of PROs for cardiovascular populations, including disease-specific and domain-specific measures, as well as international standards and guidelines for their selection. Collaboration and evaluation of PROs are needed to guide decision-making in regulatory contexts and to monitor care quality and resource allocation. New sources, such as wearable devices and electronic health records, offer opportunities for collecting PROs.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Martin R. Cowie, Gerasimos S. Filippatos, Piotr Ponikowski, Luigi Tavazzi, Jakob Schoepe, Stefan Wagenpfeil, Michel Komajda, Michael Boehm
Summary: This study evaluated the associations between baseline resting heart rate and systolic blood pressure with outcomes and treatment patterns in heart failure patients. The results showed that high resting heart rate and low systolic blood pressure were associated with worse cardiovascular outcomes, but were not the only reasons for suboptimal treatment in patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Vasileios Kouranos, Rajdeep S. Khattar, Joseph Okafor, Raheel Ahmed, Alessia Azzu, John Arun Baksi, Kshama Wechalekar, Martin R. Cowie, Athol Umfrey Wells, Thomas F. Luscher, Rakesh Sharma
Summary: This study describes the baseline characteristics of a sizable and deeply phenotyped contemporary cohort of cardiac sarcoidosis (CS) patients and investigates the predictors of poor outcomes. The study found that CS is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Serum brain natriuretic peptide levels, left ventricular ejection fraction, and myocardial inflammation were identified as independent predictors of outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Liesl Zuhlke, Jennifer Franke, Martin R. Cowie
Article
Medicine, Research & Experimental
David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbe, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum, Christian Baer
Summary: This study found that the combination of clinical information, circulating miRNAs, and decision tree learning allows the identification of specific risk subphenotypes in patients with HFrEF and CSA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Thomas Woodcock, Dionne Matthew, Raffaele Palladino, Mable Nakubulwa, Trish Winn, Hugh Bethell, Stephen Hiles, Susan Moggan, Jackie Dowell, Paul Sullivan, Derek Bell, Martin R. Cowie
Summary: This study evaluates the impact of a care bundle intervention on improving care for patients with acute heart failure. The intervention includes testing NT-proBNP, transthoracic Doppler echocardiography, and specialist evaluation. The study finds that this intervention is associated with reduced emergency readmissions and improved in-hospital mortality for acute heart failure patients.
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin R. Cowie, Praveen Thokala, Zenichi Ihara, Philip B. Adamson, Christiane Angermann
Summary: Based on the most recent data, this paper updates the cost-effectiveness analysis of CardioMEMS compared to usual care for patients with persistent New York Heart Association class III symptoms and at least one heart failure hospitalization within 12 months. The results suggest that CardioMEMS is likely to be cost-effective in the United Kingdom.
Article
Cardiac & Cardiovascular Systems
Ryan Walkley, A. Joy Allen, Martin R. Cowie, Ross Maconachie, Lisa Anderson
Summary: When relying on clinical assessment alone, an estimated 22% of acute heart failure (AHF) patients are missed. Therefore, clinical guidelines recommend the use of NT-proBNP for AHF diagnosis. However, there has been poor uptake of NT-proBNP testing due to concerns over low specificity. This study proposes the use of age-specific thresholds to improve the specificity of NT-proBNP testing.
Meeting Abstract
Respiratory System
C. Fisser, A. Ebert, L. Gall, J. Bureck, J. Priefert, S. Fredersdorf, F. Zeman, D. Linz, H. Woehrle, R. Tamisier, H. Teschler, M. Cowie, M. Arzt