Article
Pharmacology & Pharmacy
Changlin Zhen, Xunxun Wu, Jing Zhang, Dan Liu, Guoli Li, Yongbo Yan, Xiuzhen He, Jiawei Miao, Hongxia Song, Yifan Yan, Yonghui Zhang
Summary: The study found that Ganoderma lucidum polysaccharides (GLPs) can alleviate cardiac hypertrophy and fibrosis by inhibiting the expression of key genes, and attenuate pressure overload-induced pathological cardiac hypertrophy by activating PPAR?. This study provides important theoretical support for the potential use of GLPs in treating pathological myocardial hypertrophy and heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Cardiac & Cardiovascular Systems
Lin Yuan, Shichen Bu, Meng Du, Yilong Wang, Chenhui Ju, Dandan Huang, Wenjing Xu, Xin Tan, Minglu Liang, Shan Deng, Liu Yang, Kai Huang
Summary: This study investigated the role of RNF207 in the development of pathological cardiac hypertrophy and dysfunction. The results showed that RNF207 exacerbated cardiac hypertrophy and fibrosis, while RNF207 knockdown alleviated these conditions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cell Biology
Peilei Lu, Fan Ding, Yang Kevin Xiang, Liying Hao, Meimi Zhao
Summary: This article discusses the roles of various ncRNAs, including miRNAs, lncRNAs, and circRNAs, in modulating cardiac hypertrophy and heart failure in cardiovascular diseases.
Article
Medicine, Research & Experimental
Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang
Summary: OSMR deficiency exacerbates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signaling, suggesting that OSMR may be a potential target for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y. Al-Halees, Maie AlShahid, Kate S. Collison, Stephen Westaby, Futwan Al-Mohanna
Summary: Current management of heart failure focuses on symptom progression and left ventricular dysfunction. This study investigated transcriptome changes in a chronic progressive heart failure model and identified potential genes involved in the progression of heart failure for future targeted therapies.
Article
Cardiac & Cardiovascular Systems
Jiayi Liu, Wei Li, Ke-Qiong Deng, Song Tian, Hui Liu, Hongjie Shi, Qian Fang, Zhen Liu, Ze Chen, Tian Tian, Shanyu Gan, Fengjiao Hu, Manli Hu, Xu Cheng, Yan-Xiao Ji, Peng Zhang, Zhi-Gang She, Xiao-Jing Zhang, Shaoze Chen, Jingjing Cai, Hongliang Li
Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
CIRCULATION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Maria Ercu, Stephan Walter, Enno Klussmann
Summary: Hypertension with brachydactyly (HTNB) is a rare autosomal dominant form of hypertension characterized by a significant rise in blood pressure. HTNB is caused by gain-of-function mutations in the PDE3A gene, resulting in hyperactive mutant enzymes. Despite decades of hypertension, HTNB is not associated with cardiac damage commonly seen in other hypertensive conditions. The cardioprotective effect of HTNB involves local changes in cAMP signaling and inhibition of Ca2+ reuptake. Understanding the molecular mechanisms underlying HTNB could lead to improved strategies for treating essential hypertension and preventing hypertension-induced cardiac damage.
Article
Chemistry, Medicinal
G. Ian Gallicano, Jiayu Fu, Samiksha Mahapatra, Michael V. R. Sharma, Conor Dillon, Claire Deng, Maliha Zahid
Summary: Research has shown that miRNA106a can target genes that cause hypertrophy and heart failure, reversing the disease. By using a cardiac targeting peptide reversibly linked to miRNA106a, delivery specific to cardiomyocytes has been demonstrated.
Article
Cell Biology
Sai Aung Phyo, Keita Uchida, Christina Yingxian Chen, Matthew A. Caporizzo, Kenneth Bedi, Joanna Griffin, Kenneth Margulies, Benjamin L. Prosser
Summary: This study investigates the transcriptional, autoregulatory, and post-translational mechanisms that contribute to microtubule network remodeling in different stages of heart disease using heart failure patient samples and murine models. The study reveals the operability of autoregulation across tubulin isoforms in the heart and the rapid induction of microtubule detyrosination after hypertrophic stimulus. It provides insights into the rapid rewriting of the tubulin code and the tunable autoregulation of tubulin during pathological progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Zhao, Xiaoli Jiang, Jinhua Liu, Ping Ye, Lang Jiang, Manhua Chen, Jiahong Xia
Summary: The study found that DUSP26 inhibits cardiac hypertrophy and protects the heart from pressure overload-induced hypertrophy by modulating the transforming growth factor-beta activated kinase 1-p38/c-Jun N-terminal kinase signaling pathway. Therefore, DUSP26 may serve as a therapeutic target for the treatment of cardiac hypertrophy and heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Atsushi Sanbe, Yui Inomata, Naoko Matsushita, Yohei Sawa, Chizuru Hino, Hinano Yamazaki, Kei Takanohashi, Natsuko Takahashi, Rieko Higashio, Hideki Tsumura, Toshinori Aoyagi, Masamichi Hirose
Summary: This study investigated the functional role of HDAC6 in cardiac disease progression using transgenic mouse models. The findings indicate that HDAC6 activity can regulate levels of acetylated tubulin and cortactin, which play critical roles in cardiac diseases such as pressure-overload hypertrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Peripheral Vascular Disease
Ferda Demir, Kyoji Urayama, Anais Audebrand, Ayca Toprak-Semiz, Marja Steenman, Hitoshi Kurose, Canan G. Nebigil
Summary: This study reveals that pressure overload-mediated PKR2 signaling in cardiomyocytes contributes to cardiac hypertrophy through autocrine signaling, and vascular rarefaction via cardiac cytokine-mediated cardiomyocyte-endothelial cell communications. Our results may contribute to the development of potential therapeutic targets for heart failure.
Article
Biology
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark Keller, Sanjeet G. Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elzbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M. Seldin, Nadia A. Rosenthal, Gary A. Churchill, Alan Attie, Benjamin Parker, David E. James, Aldons J. Lusis
Summary: Mitochondrial variations can affect tissue-specific mitochondrial functions and contribute to heart hypertrophy. Common genetic variations in mitochondrial proteins were found to regulate cardiac functions in inbred mouse strains.
Review
Biochemistry & Molecular Biology
Shuo Li, Lina Wang, Shijin Sun, Qingyu Wu
Summary: Hepsin, a type II transmembrane serine protease highly expressed in the liver, activates prohepatocyte growth factor to regulate metabolism. It also functions in nonhepatic tissues to regulate various physiological processes. Hepsin deficiency results in metabolic abnormalities and increased risk of cancer.
Article
Genetics & Heredity
Faith Pangilinan, David Watkins, David Bernard, Yue Chen, Ningzheng Dong, Qingyu Wu, Hatice Ozel-Abaan, Manjit Kaur, Michele Caggana, Mark Morrissey, Marilyn L. Browne, James L. Mills, Carol Van Ryzin, Oleg Shchelochkov, Jennifer Sloan, Charles P. Venditti, Kyriakie Sarafoglou, David S. Rosenblatt, Denise M. Kay, Lawrence C. Brody
Summary: The p.E88del variant in the transcobalamin receptor, CD320, shows functional consequences and clinical significance in cell culture and genetic association studies, with homozygous newborns at low risk of requiring clinical intervention and minimal effects on cobalamin metabolism.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Biochemistry & Molecular Biology
Yue Chen, Xiabing Gu, Yikai Zhang, Xianrui Zhang, Ce Zhang, Meng Liu, Shijin Sun, Ningzheng Dong, Qingyu Wu
Summary: Vitamin B12 is absorbed and reabsorbed through receptor-mediated endocytosis, with CD320 playing a key role in cellular uptake. This study explores the distribution and cellular expression of CD320 in mouse kidneys and intestines, revealing its involvement in vitamin B12 absorption in the small intestine and reabsorption in the kidney. Furthermore, a specific amino acid motif in CD320 is identified as crucial for its apical membrane targeting in both renal and intestinal epithelial cells, and this targeting is mediated by a Rab11a-dependent mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Genetics & Heredity
Wenxing Zhan, Liping Chen, Hongfei Liu, Changkun Long, Jiankun Liu, Shuangjin Ding, Qingyu Wu, Shenghan Chen
Summary: PCSK6 expression is decreased in cardiac aging and it modulates cardiomyocyte senescence possibly via DDIT3-mediated endoplasmic reticulum stress.
Review
Biology
Xianrui Zhang, Xiabing Gu, Yikai Zhang, Ningzheng Dong, Qingyu Wu
Summary: ANP is a crucial hormone that plays a key role in regulating various physiological and pathological processes. Corin, a transmembrane protease, activates ANP and is associated with cardiovascular disease. Recent studies indicate that corin-mediated ANP production and signaling are important for maintaining cardiovascular homeostasis.
Article
Biology
Xianrui Zhang, Wenguo Li, Tiantian Zhou, Meng Liu, Qingyu Wu, Ningzheng Dong
Summary: Thermoregulation is crucial for endothermic animals. This study found that corin deficiency in mice affects adipose tissue function and thermoregulation, leading to hypothermia.
Review
Biochemistry & Molecular Biology
Qingyu Wu, Shenghan Chen
Summary: PCSK6 is a secreted serine protease expressed in various organs, playing important roles in embryonic development, cardiovascular functions, and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tiantian Zhou, Shengnan Zhang, Chunyu Du, Kun Wang, Xiabing Gu, Shijin Sun, Xianrui Zhang, Yayan Niu, Can Wang, Meng Liu, Ningzheng Dong, Qingyu Wu
Summary: This study demonstrates the importance of renal Corin function in enhancing natriuresis upon high salt intake and the inability of cardiac Corin function to compensate for it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yikai Zhang, Shijin Sun, Chunyu Du, Kaixuan Hu, Ce Zhang, Meng Liu, Qingyu Wu, Ningzheng Dong
Summary: This study investigated the cellular mechanisms regulating TMPRSS2 activity and cell surface expression. The researchers found that TMPRSS2 is activated via intracellular autocatalysis and N-glycosylation plays a key role in protein folding and cell surface expression. Additionally, TMPRSS2 can cleave the SARS-CoV-2 spike protein intracellularly.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Wen Wang, Bin Zuo, Yao Wang, Xinyu Li, Zhen Weng, Juping Zhai, Qingyu Wu, Yang He
Summary: This study investigated the levels of megakaryocyte- and platelet-derived microparticles (MKMPs and PMPs) in the plasma of patients with immune thrombocytopenia (ITP). The results showed that MKMP and PMP levels were significantly lower in ITP patients compared to healthy controls, and higher than in non-immune thrombocytopenia patients. Additionally, the levels of MKMPs and PMPs could be used as biomarkers for the diagnosis of ITP and prediction of response to thrombopoietin receptor agonist (TPO-RA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shijin Sun, Kaixuan Hu, Lina Wang, Meng Liu, Yikai Zhang, Ningzheng Dong, Qingyu Wu
Summary: In this study, the importance of N-glycosylation site positions in the SRCR domain of hepsin was examined. The presence of an N-glycan in a confined surface area within the SRCR domain was found to be essential for proper protein folding and activation of hepsin on the cell surface. These findings contribute to our understanding of the conservation and functionality of N-glycosylation sites in the SRCR domains of different proteins.
Review
Biochemistry & Molecular Biology
Qingyu Wu, Shuo Li, Xianrui Zhang, Ningzheng Dong
Summary: TTSPs play a crucial role in regulating adipose tissue phenotype, energy metabolism, and thermoregulation through various signaling mechanisms.
Article
Cardiac & Cardiovascular Systems
Yayan Niu, Tiantian Zhou, Shengnan Zhang, Wenguo Li, Kun Wang, Ningzheng Dong, Qingyu Wu
Summary: Corin deficiency impairs cardiac function and exacerbates heart failure development. Treatments with recombinant corin protein can reduce cardiac hypertrophy and fibrosis and improve cardiac function. This finding provides a new approach for treating heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biology
Xiabing Gu, Kun Wang, Wenguo Li, Meiling He, Tiantian Zhou, Meng Liu, Qingyu Wu, Ningzheng Dong
Summary: Sodium homeostasis is critical for body fluid balance, and the kidney plays a central role in regulating sodium reabsorption and excretion. In this study, Corin and ANP were found to be expressed in the mouse intestine, where sodium excretion also occurs. This reveals a new function of Corin in promoting sodium excretion in the intestinal tract.
Review
Biochemistry & Molecular Biology
Qingyu Wu
Summary: Endometrial decidualization is crucial for various uterine processes in pregnancy. Atrial natriuretic peptide (ANP) has been found to play a significant role in these processes. Deficiencies in ANP signaling can lead to complications such as preeclampsia. This review examines the impact of impaired ANP signaling on uterine biology and its potential implications for preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)