Article
Biochemistry & Molecular Biology
Laia Yanez-Bisbe, Anna Garcia-Elias, Marta Tajes, Isaac Almendros, Antonio Rodriguez-Sinovas, Javier Inserte, Marisol Ruiz-Meana, Ramon Farre, Nuria Farre, Begona Benito
Summary: This study found that elderly female mice are more vulnerable to developing HFrEF compared to young animals, and exhibit impaired reverse remodeling with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Doa'a G. F. Al-U'datt, Carole C. Tranchant, Muhammad Alu'datt, Sara Abusara, Ahmed Al-Dwairi, Mohammad AlQudah, Othman Al-shboul, Roddy Hiram, Yasemin Altuntas, Saied Jaradat, Karem H. Alzoubi
Summary: This study aimed to investigate the effects of cystamine on isoproterenol-induced cardiac fibrosis and dysfunction. The results showed that cystamine administration could reduce cardiac fibrosis, decrease profibrotic marker expression, and protect cardiac function.
Article
Cardiac & Cardiovascular Systems
Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N. Simon, Simona Mafrici, Ritu Arya, Esther Rosello-Lleti, Surawee Chuaiphichai, Damian Tyler, Craig A. Lygate, Keith M. Channon, Barbara Casadei
Summary: Myocardial BH4 was found to prevent and reverse left ventricular diastolic and systolic dysfunction associated with diabetes by increasing insulin-independent myocardial glucose uptake and utilization. This mechanism highlights the potential for GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi
Summary: HRV indices are associated with worse systolic function in men and improvement in left atrial size in women. Higher HRV is associated with a higher risk of new-onset HF in men.
Article
Medicine, Research & Experimental
Ke Feng, Yuxin Liu, Jia Sun, Chunlai Zhao, Yajun Duan, Wenjia Wang, Kaijing Yan, Xijun Yan, He Sun, Yunhui Hu, Jihong Han
Summary: The study showed that Compound DanShen Dripping Pill (CDDP) can protect mice against heart failure-induced injuries and restore cardiac function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
YaJuan Ni, Jing Zhang, Wenjing Zhu, Yixuan Duan, HongYuan Bai, Chunhong Luan
Summary: The study found that Echinacoside (ECH) can inhibit cardiomyocyte pyroptosis and improve heart function by suppressing the NADPH/ROS/ER stress pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jia-Bao Huang, Zhi-Ru Chen, Shu-Long Yang, Fen-Fang Hong
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by severe joint damage and disability. Nitric oxide (NO) and nitric oxide synthases (NOS) play a significant role in the pathogenesis of RA by inducing inflammation and oxidative stress. Targeting NOS/NO signaling pathways may be an effective approach for managing RA, and there are several drugs currently in clinical trials that show promise in treating RA by modulating NOS/NO activity.
Article
Pharmacology & Pharmacy
Ying Shi, Lili Zhao, Jing Wang, Shan Liu, Yifei Zhang, Qin Qin
Summary: In this study, the researchers found that inhibiting the NLRP3 inflammasome with MCC950 improved cardiac dysfunction induced by ISO, including cardiac fibrosis, hypertrophy, and inflammation. Furthermore, MCC950 also attenuated ISO-induced oxidative stress and cell senescence.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinfu Qian, Shiqi Liang, Qinyan Wang, Jiachen Xu, Weijian Huang, Gaojun Wu, Guang Liang
Summary: Heart failure (HF) is a major cause of illness and death worldwide. Toll-like receptor-2 (TLR2) plays a role in the inflammatory response during cardiac remodeling induced by isoproterenol (ISO). TLR2 knockdown reduces inflammation and remodeling in ISO-treated cells through the MAPKs/NF-κB signaling pathway. TLR2 may be a potential target for alleviating chronic adrenergic stimulation-associated HF.
Article
Medicine, Research & Experimental
Faeze Keihanian, Mohsen Moohebati, Amin Saeidinia, Seyed Ahmad Mohajeri, Saeid Madaeni
Summary: This study evaluated the effects of ten herbals on chronic heart failure (CHF) treatment and found that Allium sativum, Peganum harmala, and Berberis vulgaris showed significant improvement in cardiac function without toxic effects on renal and liver tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Haijuan Sun, Jingjing Bai, Yuting Sun, Dong Zhen, Danni Fu, Yu Wang, Chengxi Wei
Summary: Our study found that Oxymatrine improved the survival of isoproterenol-induced heart failure mice. It achieved this by inhibiting the expression of inflammatory cytokines TNF-a and IL-6, reducing TLR4 levels, and decreasing the phosphorylation levels of NF-xB, p65, JNK, and p38. Animal experiments showed that Oxymatrine alleviated isoproterenol-induced cardiac injury, necrosis, interstitial edema, and fibrosis, while inhibiting the expression of TLR4/NF-xB and MAPK pathway-related proteins.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Peschanski, Najah Harouki, Matthieu Soulie, Marianne Lachaux, Lionel Nicol, Isabelle Remy-Jouet, Jean-Paul Henry, Anais Dumesnil, Sylvanie Renet, Francoise Fougerousse, Ebba Brakenhielm, Antoine Ouvrard-Pascaud, Christian Thuillez, Vincent Richard, Jerome Roussel, Paul Mulder
Summary: Early transient heart rate reduction induced by the I-f current inhibitor S38844 can prevent the aggravation of cardiovascular dysfunction and development of pulmonary congestion in ADHF, as shown in a rat model. These protective effects persist beyond the transient treatment period.
Article
Biochemistry & Molecular Biology
Anna Drohomirecka, Joanna Was, Natalia Wiligorska, Tomasz M. Rywik, Krzysztof Komuda, Dorota Sokolowska, Anna Lutynska, Tomasz Zielinski
Summary: Methylated arginine metabolites can disrupt nitric oxide synthesis, leading to endothelium dysfunction and inadequate vasodilation. This study aimed to investigate the dynamics of arginine derivatives during physical exercise in heart failure patients and assess its impact on patient outcomes.
Article
Biotechnology & Applied Microbiology
Ji Wu, Yang Fu, Ying-xing Wu, Zu-xiang Wu, Zhen-hua Wang, Ping Li
Summary: The study showed that Lycorine can improve isoproterenol-induced cardiac dysfunction and histopathological injury, potentially through inhibiting inflammation, fibrosis, oxidative stress, and apoptosis.
Review
Biochemistry & Molecular Biology
Gabriele Serreli, Monica Deiana
Summary: Nitric oxide (NO) is released in various organs and tissues and has important functions in organisms. There are three isoforms of the enzyme that produce NO, namely eNOS, iNOS, and nNOS. The expression and activity of these isoforms depend on different intracellular signaling pathways. Recent studies have focused on natural compounds like polyphenols, which can be obtained through diet, for their ability to modulate NOS isoforms' pathways. In this review, we aim to provide scientific evidence on the activity of dietary polyphenols in regulating NOS isoform expression and functionality.
Article
Cardiac & Cardiovascular Systems
Katarina Hadova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Zuzana Kmecova, Peter Krenek, Jan Klimas
Summary: Despite disrupted repolarization in diabetic hearts, some studies suggest a reduced tendency for ventricular arrhythmias, indicating a compensatory mechanism. This study found that mRNA and protein expression of HCN2 decreased exclusively in the ventricles of diabetic rats, with stable microRNA levels and decreased mRNA levels of potassium channels involved in repolarization. This suggests that HCN channels may play a role in ventricular electric remodeling and altered arrhythmogenic profile in diabetic hearts.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Allan Bohm, Lubos Urban, Lubomira Tothova, Ljuba Bacharova, Peter Musil, Jan Kyselovic, Peter Michalek, Tomas Uher, Branislav Bezak, Peter Olejnik, Robert Hatala
Summary: This study investigated oxidative stress biomarkers in patients undergoing PVI for paroxysmal AF, finding that lower concentration of AGEs was associated with optimal long-term PVI outcome. Patients with lower AGEs concentration had lower AF burden after PVI, suggesting potential value in predicting PVI response.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Physiology
Jan Kyselovic, Nikola Chomanicova, Adriana Adamickova, Simona Valaskova, Barbara Salingova, Andrea Gazova
Summary: Experimental data on the bioavailability of different Mg-salts in the human body is inconsistent. This study aimed to assess the bioavailability and accessibility of magnesium in different Mg-salt compounds using an in vitro model. Results showed that varying Mg-salts had different absorption rates and cell viabilities, with increasing Mg concentration leading to decreased cell count and viability.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Physiology
Magdalena Kovarova, Zuzana Zilinska, Jan Pales, Zuzana Kuzmova, Andrea Gazova, Juraj Smaha, Martin Kuzma, Peter Jackuliak, Viera Stvrtinova, Jan Kyselovic, Juraj Payer
Summary: CKD patients, particularly those with ESRD undergoing dialysis, often experience cardiac structural changes more prominently than functional changes. ABI may not be suitable for assessing cardiovascular risk in this patient population, while echocardiography proves to be an effective tool in evaluating cardiac structure and function.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Igor Straka, Michal Minar, Milan Grofik, Matej Skorvanek, Veronika Bolekova, Andrea Gazova, Jan Kyselovic, Peter Valkovic
Summary: The use of pillbox organizers with alarms has been shown to effectively improve adherence to pharmacotherapy in patients with Parkinson's disease. This study demonstrated that after only four weeks of using the pillbox organizer, patients experienced improved quality of life, motor involvement, and motor and non-motor fluctuations.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Zdenko Cervenak, Filip Cervenak, Adriana Adamickova, Barbara Salingova, Andrea Gazova, Jan Kyselovic
Summary: The study aimed to identify a set of suitable reference genes in normal and failing left ventricle tissues, in order to increase the reliability of future RT-qPCR-based studies. Using a two-step approach, the expression of 15 commonly used housekeeping genes was analyzed, and IPO8 and POLR2A were identified as the most stably expressed genes. The study also provided guidelines for the selection of reference genes in studies comparing gene expression in these types of tissues.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Infectious Diseases
Juraj Smaha, Martin Kuzma, Kristina Brazdilova, Samuel Nachtmann, Martin Jankovsky, Katarina Pastirova, Andrea Gazova, Peter Jackuliak, Zdenko Killinger, Jan Kyselovic, Tomas Koller, Neil Binkley, Juraj Payer
Summary: This study aimed to evaluate the mortality rate in COVID-19 patients with severe vitamin D deficiency. The results showed that patients with serum 25(OH) D levels <12 ng/ml had higher mortality, viral load, and Charlson comorbidity index. Lower 25(OH) D levels at the time of admission were independently associated with mortality, suggesting that severe vitamin D deficiency may contribute to poor outcomes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Izabela Jarabicova, Csaba Horvath, Eva Velasova, Lenka Bies Pivackova, Jana Veteskova, Jan Klimas, Peter Krenek, Adriana Adameova
Summary: This study investigated the role of cell loss due to necroptosis and its connection with pyroptosis in organ damage caused by pulmonary arterial hypertension (PAH). The findings suggest that the upregulation of pThr(231)/Ser(232)-RIP3 may contribute to the pathophysiology of PAH and that plasma RIP3 could serve as a potential diagnostic and prognostic marker of cardiac injury in these conditions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Dermatology
Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin
Summary: Infrared light therapy has positive effects on relieving musculoskeletal pain through several mechanisms, including increasing nitric oxide availability and reducing inflammation.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Letter
Clinical Neurology
Simona Stankova, Zuzana Kosutzka, Igor Straka, Andrea Gazova, Michal Minar
ACTA NEUROLOGICA BELGICA
(2023)
Article
Pharmacology & Pharmacy
Katarina Hadova, Jana Kmecova, Katarina Ochodnicka-Mackovicova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Peter Vavrinec, Tatiana Stankovicova, Peter Krenek, Jan Klimas
Summary: Simultaneous administration of clarithromycin and furosemide in rats can cause drug-induced LQTS and TdP, which may be related to ion channel reprogramming in the hearts of rats.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Biochemistry & Molecular Biology
Adriana Adamickova, Nikola Chomanicova, Andrea Gazova, Juraj Mad'aric, Zdenko Cervenak, Simona Valaskova, Matus Adamicka, Jan Kyselovic
Summary: Stem cell transplantation is an important tool in tissue engineering and regenerative medicine. This study investigates the effect of atorvastatin on bone-marrow-derived mesenchymal stem cells (BM-MSCs) in vitro. The results show that atorvastatin does not decrease the cell viability of BM-MSCs and has various effects on gene expression and signaling pathways. These findings suggest that atorvastatin can improve the therapeutic efficacy of BM-MSC treatment by upregulating angiogenesis-related genes and modulating the PI3K/AKT/mTOR pathway.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Ivo Gasparovic, Panagiotis Artemiou, Andrej Domonkos, Branislav Bezak, Andrea Gazova, Jan Kyselovic, Michal Hulman
Summary: This study compares the real-world outcomes between patients who underwent off-pump surgery and a hybrid procedure with percutaneous revascularisation at a later stage. The results show that both strategies have comparable long-term mortality.
MEDICINA-LITHUANIA
(2023)