Article
Multidisciplinary Sciences
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd'herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Summary: Solid tumor cells have altered metabolism that can protect them from cytotoxic lymphocytes, but metformin can increase tumor cell sensitivity to cytotoxic lymphocytes. Research shows that metformin induces expression of NKG2DL and ICAM-1, promoting binding between lymphocytes and tumor cells, and reducing the growth of human hematological tumor cells.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ying Liu, Pengbiao Xu, Sophie Rivara, Chong Liu, Jonathan Ricci, Xuefeng Ren, James H. Hurley, Andrea Ablasser
Summary: The adaptor protein complex 1 (AP-1) controls the termination of STING-dependent immune activation by sorting phosphorylated STING into transport vesicles for degradation.
Article
Cell Biology
Zhijie Chen, Yingqian Zhong, Jiehong Chen, Shuxin Sun, Wenfeng Liu, Yu Han, Xincheng Liu, Cui Guo, Depei Li, Wanming Hu, Peiyu Zhang, Zhuopeng Chen, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu, Wei Yin, Ke Sai
Summary: This study demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in GSCs. In addition, cAMP induced negative feedback to antagonize the differentiation process by activating beta-catenin pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Julia Katharina Scholz, Andre Kraus, Dominik Lueder, Kathrin Skoczynski, Mario Schiffer, Steffen Grampp, Johannes Schoedel, Bjoern Buchholz
Summary: Autosomal dominant polycystic kidney disease is caused by mutations in the PKD1 gene, resulting in the loss of Polycystin-1 and leading to the formation of renal cysts. The role of cAMP in cyst initiation is not well understood. Deletion of Polycystin-1 in collecting duct cells leads to a switch from tubule to cyst formation, accompanied by increased cAMP. Pharmacological elevation of cAMP in Polycystin-1-competent cells resembles the phenotype of Polycystin-1-deficient cells, including impaired plasticity and mis-orientation of tubule cells.
Article
Multidisciplinary Sciences
Derek J. Prince, Deendayal Patel, Scott C. Kachlany
Summary: LtxA is a protein secreted by oral bacterium that targets and kills activated white blood cells. Its interaction with T-cells leads to cell death through increased intracellular calcium, activation of caspases, and involvement of the Fas death receptor. LtxA can kill malignant lymphocytes through apoptotic and necrotic forms of cell death, involving Panx1 channels and P2X(7)Rs.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ayoze Gonzalez-Santana, Judith Estevez-Herrera, Elizabeth P. Seward, Ricardo Borges, Jose David Machado
Summary: Glucagon-like-peptide-1 receptor agonists are commonly used for treating type 2 diabetes and obesity, with benefits focused on the pancreas and hypothalamus. However, the role of GLP-1R in adrenal medulla secretions is less understood. Experiments show that Exendin-4 enhances catecholamine synthesis and release through cAMP production, while also regulating the quantum size of exocytotic events.
Article
Oncology
Erika Tissino, Eliana Pivetta, Alessandra Capuano, Guido Capasso, Riccardo Bomben, Chiara Caldana, Francesca Maria Rossi, Federico Pozzo, Dania Benedetti, Renzo Boldorini, Gianluca Gaidano, Davide Rossi, Alberto Zamo, Tanja Nicole Hartmann, Roberto Doliana, Alfonso Colombatti, Valter Gattei, Paola Spessotto, Antonella Zucchetto
Summary: The study demonstrates that EMILIN-1 is widely present in CLL-involved tissues with diverse expression patterns, and its interaction with VLA-4 promotes adhesion of CLL cells and provides pro-survival signals, contributing to the maintenance of the neoplastic clone in CLL.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Ziying Huang, Qianqian Li, Mengxun Li, Changchun Li
Summary: By studying the role of lincRNA in skeletal muscle development in different breeds of pigs, multiple lincRNAs that may cause differences in skeletal muscle development between the two breeds were identified, and their possible regulatory roles were explored. The findings of this study may provide a valuable reference for further research on the role of lincRNA in skeletal muscle development.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Gillian Forbes, Zhi-Hui Chen, Koryu Kin, Pauline Schaap
Summary: Cell differentiation in Dictyostelia was studied using RNA-seq and lacZ expression validation to investigate the spatio-temporal expression pattern of cell-type specific genes. The study revealed common modes of regulation for spore and cup genes, and specific regulation for stalk-expressed genes. Additionally, the presence of a stem-cell like soma population in slugs was indicated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D'Mello, Christina Finn, P. M. Abdul-Muneer
Summary: ICAM-1 plays a significant role in traumatic brain injury, mediating neuroinflammation and cell death. Deletion or blocking of ICAM-1 helps attenuate neuroinflammation and improve functional outcomes.
Article
Medicine, Research & Experimental
Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M. Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis
Summary: The secreted protein DEL-1 plays a critical role in regulating inflammatory cell recruitment and protecting against inflammatory arthritis. DEL-1 functions both locally in the joints and systemically in lymph nodes to inhibit Tfh responses, making it a promising therapeutic target for inflammatory arthritis treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yoshihiko Kuchitsu, Kojiro Mukai, Rei Uematsu, Yuki Takaada, Ayumi Shinojima, Ruri Shindo, Tsumugi Shoji, Shiori Hamano, Emari Ogawa, Ryota Sato, Kensuke Miyake, Akihisa Kato, Yasushi Kawaguchi, Masahiko Nishitani-Isa, Kazushi Izawa, Ryuta Nishikomori, Takahiro Yasumi, Takehiro Suzuki, Naoshi Dohmae, Takefumi Uemura, Glen N. N. Barber, Hiroyuki Arai, Satoshi Waguri, Tomohiko Taguchi
Summary: Stimulator of interferon genes (STING) is crucial for the immune response against DNA pathogens, and its degradation is mediated by endosomal sorting complexes required for transport (ESCRT) proteins. STING-positive vesicles derived from recycling endosomes are encapsulated into lysosomes after STING ubiquitination. This study provides insights into the regulation of STING and prevents hyperactivation of the immune response.
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Anita Sapoznikov, Stav Kozlovski, Nehora Levi, Sara W. Feigelson, Ofer Regev, Natalia Davidzohn, Shifra Ben-Dor, Rebecca Haffner-Krausz, Ester Feldmesser, Noa Wigoda, Ekaterina Petrovich-Kopitman, Moshe Biton, Ronen Alon
Summary: Lymphocyte priming in lymph nodes was believed to require stable immune synapses between T cells and antigen-presenting dendritic cells. The role of ICAM-1 in these synapses was investigated in vivo and it was found that although ICAM-1 is involved in stable conjugates between DCs and CD8 blasts, these conjugates are not essential for proliferation and differentiation of CD8 lymphocytes. The results suggest that firm immune synapses are dispensable for TCR-triggered lymphocyte proliferation and differentiation into effector lymphocytes.
Article
Multidisciplinary Sciences
Grace Aprilia Helena, Teruhiko Watanabe, Yusuke Kato, Nobuaki Shiraki, Shoen Kume
Summary: By adjusting the thawing protocol and medium composition, we successfully improved the attachment of PHH cells on the collagen matrix. Removing BSA and exposing the cells to cAMP activators such as IBMX and Forskolin enhanced PHH attachment. Activation of EPAC2 increased PHH attachment and induced bile canaliculi formation in iPS-derived hepatocytes.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Chengqiang Wang, Gen Liu, Guojun Dou, Yi Yang, Lu Chen, Hui Ma, Zhuyun Jiang, Haoyue Ma, Chenglong Li, Li Li, Mingdong Jiang, Qianwei Lu, Pan Li, Hongyi Qi
Summary: The study demonstrates that Z-LIG selectively inhibits the viability of human AML cells, suppresses proliferation and colony formation, and restores Nur77 and NOR-1 expression in AML cells, thereby promoting apoptosis and differentiation.
