Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
K. G. Yang, W. Y. W. Lee, A. L. H. Hung, V. W. Y. Hung, M. F. Tang, T. F. Leung, A. P. S. Kong, J. C. Y. Cheng, T. P. Lam
Summary: Girls with adolescent idiopathic scoliosis (AIS) show decreased cortical bone density and bone strength during peak height velocity (PHV), along with elevated bone turnover markers (BTMs). This aligns with previous research indicating that low bone mineral density (BMD) is a prognostic factor for curve progression in AIS during PHV.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ian H. de Boer, Jye-Yu C. Backlund, Valerie Arends, Rose Gubitosi-Klug, Amisha Wallia, Naina Sinha Gregory, Annette Barnie, Andrew J. Burghardt, John M. Lachin, Barbara H. Braffett, Ann Schwartz
Summary: Poor glycemic control is associated with reduced bone formation in T1D patients, while reduced kidney function is associated with increased bone resorption and formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Christian Meier, Richard Eastell, Dominique D. Pierroz, Nancy E. Lane, Nasser Al-Daghri, Atsushi Suzuki, Nicola Napoli, Ambrish Mithal, Marlene Chakhtoura, Ghada El-Hajj Fuleihan, Serge Ferrari
Summary: This review provides a summary of current data on biochemical markers in relation to bone fragility and fracture risk in diabetes. The results show that although bone resorption and bone formation markers are not effective predictors of fracture risk in diabetes, osteoporosis drugs have similar effects on bone turnover markers in both diabetics and nondiabetics, resulting in reduced fracture risk. Other biochemical markers related to bone and glucose metabolism, such as sclerostin, glycated hemoglobin A(1c), and inflammatory markers, as well as hormones like insulin-like growth factor-1 and calciotropic hormones, are also associated with bone mineral density and fracture risk in diabetes. HbA(1c) levels appear to be the most reliable estimate of fracture risk, while bone turnover markers can be used to monitor the effects of antiosteoporosis therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Review
Nutrition & Dietetics
Khemayanto Hidayat, Jing-Si Chen, Tian-Ci Wang, Yu-Jie Liu, Yu-Jie Shi, Hong-Wen Su, Biao Liu, Li-Qiang Qin
Summary: This meta-analysis study suggests that milk supplementation can have a positive impact on hip and lumbar spine bone density, as well as reducing bone turnover markers and parathyroid hormone concentrations, potentially preventing bone loss.
ADVANCES IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Julie Abildgaard, Thorkil Ploug, Anette Tonnes Pedersen, Pia Eiken, Bente Klarlund Pedersen, Jens Juul Holst, Bolette Hartmann, Birgitte Lindegaard
Summary: Despite higher fasting levels, postmenopausal women exhibit comparable postprandial suppression of bone turnover markers to premenopausal women. None of the postprandial gut hormone increases predict postprandial bone turnover suppression.
Article
Dentistry, Oral Surgery & Medicine
Seok Woo Hong, Jeong-Hyun Kang
Summary: The development and progression of TMJ OA may be associated with bone metabolism and condylar quality according to this study. Significant correlations between various bone metabolism markers and the stages of TMJ OA were observed in young and post-menopausal females.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Geriatrics & Gerontology
Sarah J. Wherry, Christine M. Swanson, Wendy M. Kohrt
Summary: Exercise is recommended for cardiometabolic benefits and bone health, but may lead to bone loss in certain conditions. Disruption in calcium homeostasis during exercise could diminish skeletal benefits and factors such as age, sex, and exercise intensity may influence the magnitude of this disruption.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Nicola Hepp, Anja Lisbeth Frederiksen, Morten Duno, Niklas Rye Jorgensen, Jens-Erik Beck Jensen
Summary: HPP is a rare disease affecting bone mineralization, with adults having an increased occurrence of low-energy fractures and reduced physical performance compared to healthy controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Ran Li, Xiaoyi Zhu, Mengxi Zhang, Guannan Zong, Keqin Zhang
Summary: The study aimed to investigate the serum periostin levels in Chinese postmenopausal women with different bone mass and its correlations with traditional bone turnover markers and bone mineral densities at different sites. The results showed no significant difference in serum periostin levels among the groups of women with normal bone mass, osteopenia, and osteoporosis. Additionally, the study found that serum P1NP and OC levels may be better predictors of osteoporosis in Chinese postmenopausal women than serum periostin.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Environmental Sciences
Wieslaw Kanadys, Agnieszka Baranska, Agata Blaszczuk, Malgorzata Polz-Dacewicz, Bartlomiej Drop, Maria Malm, Krzysztof Kanecki
Summary: This systematic review and meta-analysis study suggests that intake of soy isoflavones may lead to an increase in bone formation markers and a decrease in bone resorption markers. However, these trends were not statistically significant. Further extensive multi-center research is needed to confirm the potential beneficial effects of soy isoflavones on bone health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)