Article
Endocrinology & Metabolism
Fang Zhong, Liying Guan, Haiyan Lin, Meng Zhao, Yiming Qin, Qihang Li, Zhongshang Yuan, Guang Yang, Ling Gao, Jiajun Zhao
Summary: Elevated red blood cell count is independently associated with a high risk of NAFLD incidence and progression. This indicates that red blood cell count may be a convenient NAFLD risk indicator.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Agata Michalak, Malgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Tomasz Lach, Halina Cichoz-Lach
Summary: This study investigated the blood markers in patients with alcohol-related liver cirrhosis and metabolic-associated fatty liver disease. The results showed that RDW and its derivatives may serve as valuable diagnostic markers and are associated with liver function deterioration in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hunain Aslam, Fouzia Oza, Khalid Ahmed, Jonathan Kopel, Mark M. M. Aloysius, Aman Ali, Dushyant Singh Dahiya, Muhammad Aziz, Abhilash Perisetti, Hemant Goyal
Summary: Liver disease is a major public health concern, and researchers are searching for a low-cost, easily accessible, non-invasive marker to monitor and predict liver disorders. The red blood cell distribution width (RDW) has been found to be associated with various inflammatory conditions, suggesting its potential use as a marker for disease progression and prognosis. Multiple factors affect red blood cell production, and dysfunctions in these processes can lead to an increase in RDW. Chronic inflammation also contributes to increased oxidative stress, dysregulation, and reduced erythropoiesis, further increasing RDW. This literature review explores the pathophysiology behind the increase in RDW and its potential correlation with various chronic liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ji Taek Hong, Min-Jung Lee, Sang Jun Yoon, Seok Pyo Shin, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Gi Soo Youn, Min Jea Shin, Young Lim Ham, Ki Tae Suk, Bong-Soo Kim
Summary: This study showed that in patients with nonalcoholic steatohepatitis, KRG effectively improved liver enzymes and fatigue score by modulating gut-microbiota, while the placebo group had less improvement.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Medical Laboratory Technology
Ya Xi, Yongying Bai
Summary: This study indicates that RDW, PDW, and RPR can be used as novel indicators for differentiating HLH, and are easily detectable and cost-effective. PDW and RPR serve as useful indices for monitoring the treatment effects on HLH.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Endocrinology & Metabolism
Guowei Zhou, Yueqin Ai, Song Guo, Quan Chen, Xiao Feng, Kun Xu, Gaoyuan Wang, Chaoqun Ma
Summary: This study investigated the association between red blood cell distribution width (RDW) and thyroid function in the US population. The results showed a J-shaped curve association between RDW and thyroid-stimulating hormone (TSH), a negative association between RDW and free triiodothyronine (fT3), and a higher likelihood of subclinical hypothyroidism with elevated RDW. Overall, RDW may serve as a significant clinical marker for subclinical hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Biomedical
Kun Du, Shibo Li, Chengpan Li, Ping Li, Chunguang Miao, Tianzhi Luo, Bensheng Qiu, Weiping Ding
Summary: This study develops a biomimetic liver lobule chip and establishes a more accurate on-chip NAFLD model, demonstrating for the first time the changes in lipid zonation in a liver lobule with the progression of NAFLD on a microfluidic chip. The application of the induced NAFLD model has shown promise in the prevention and reversibility of drug treatments, providing a platform for understanding NAFLD progression and identifying potential drug therapies.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Francesco Petrella, Monica Casiraghi, Davide Radice, Andrea Cara, Gabriele Maffeis, Elena Prisciandaro, Stefania Rizzo, Lorenzo Spaggiari
Summary: The ratio of hemoglobin to red cell distribution width (HRR) is an effective prognostic factor in various types of cancer, including resected-lung-adenocarcinoma patients. Pre-operative HRR has been shown to be a significant predictor of disease-free survival in this patient population, along with the level of pathologic node involvement.
Review
Gastroenterology & Hepatology
Richie Manikat, Mindie H. Nguyen
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is associated with metabolic syndrome and often presents with comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD is also linked to non-liver comorbidities including cardiovascular disease, chronic kidney disease, and sleep apnea. Managing these comorbidities is crucial for improving liver-related and overall health outcomes in patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Muge Ustaoglu, Gulali Aktas, Ufuk Avcioglu, Berk Bas, Bugra Kaan Bahceci
Summary: The study found that levels of AST, ALT, CRP, RDW, and PDW were significantly higher in ALD patients compared to the control group, with RDW significantly correlated with AST and CRP, and PDW significantly correlated with AST, ALT, and CRP. RDW and PDW demonstrate considerable sensitivity and specificity in determining ALD.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Virology
Zhong-hua Wang, Bing-qi Fu, Ying-wen Lin, Xue-biao Wei, Heng Geng, Wei-xin Guo, Hui-qing Yuan, You-wan Liao, Tie-he Qin, Fei Li, Shou-hong Wang
Summary: This study found that the red blood cell distribution width (RDW) is a good factor for identifying the severity of COVID-19, with an RDW cutoff of 11.5% being optimal for determining critical illness in COVID-19 infections.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, General & Internal
Biagio Di Lorenzo, Maria Carmina Pau, Elisabetta Zinellu, Arduino A. A. Mangoni, Panagiotis Paliogiannis, Pietro Pirina, Alessandro G. G. Fois, Ciriaco Carru, Angelo Zinellu
Summary: Although polysomnography is the gold standard method to diagnose OSAS, there is a search for simpler and cheaper biomarkers. This study reviewed the potential diagnostic role of RDW, a routine hematological parameter, in OSAS. The results suggest that RDW could be a promising biomarker for OSAS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Andrew Xanthopoulos, Grigorios Giamouzis, Apostolos Dimos, Evangelia Skoularigki, Randall C. Starling, John Skoularigis, Filippos Triposkiadis
Summary: This study discusses the role and predictive value of red blood cell distribution width (RDW) in heart failure, explores the possible mechanisms of RDW increase, and its prognostic role in heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Lijuan Xi, Fang Fang, Jiajie Zhou, Peirong Xu, Yan Zhang, Pingting Zhu, Jiayuan Tu, Qiannan Sun
Summary: This study found an inverse association between HRR and depression in older adults, suggesting that HRR could be an independent risk factor for depression. HRR has the potential to facilitate early detection and prevention of clinical deterioration or relapses in depression, and could serve as a viable treatment target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Immunology
Wenhui Zhang, Ren Lang
Summary: NAFLD and NASH are significant contributors to liver disease worldwide. Macrophages play a crucial role in the pathogenesis of NAFLD and NASH, and their metabolic characteristics influence their activation state and functionality. Targeting macrophage metabolism could be a promising therapeutic approach for the management of NAFLD/NASH.
FRONTIERS IN IMMUNOLOGY
(2023)