Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Hwan Kim, Sang Hyun Choi, Dong Wook Kim, Seung Soo Lee, Young-Suk Lim, So Yeon Kim, Hyoung Jung Kim, Jin Hee Kim, Jae Ho Byun
Summary: This study compared the clinical and MRI characteristics of cHCC-CCA patients with and without HCC risk factors. Despite significant differences in MRI features, post-surgical prognosis did not vary between the two groups. LI-RADS category and pathologic tumor type were independently correlated with post-surgical prognosis in patients with cHCC-CCA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Yanling Chen, Qing Lu, Weibin Zhang, Jiaying Cao, Yi Dong, Wenping Wang
Summary: A predictive nomogram based on clinical and ultrasound findings was established to distinguish combined hepatocellular-cholangiocarcinoma (CHC) from other subtypes of primary liver cancers (PLCs). The nomogram showed promising performance and clinical usefulness in differentiating CHC from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Julien Calderaro, Luca Di Tommaso, Pascale Maille, Aurelie Beaufrere, Cong Trung Nguyen, Lara Heij, Viviane Gnemmi, Rondell P. Graham, Frederic Charlotte, Suzanne Chartier, Dominique Wendum, Mukul Vij, Daniela Allende, Alba Diaz, Carla Fuster, Benjamin Riviere, Astrid Herrero, Jeremy Augustin, Katja Evert, Diego Francesco Calvisi, Wei Qiang Leow, Howard Ho Wai Leung, Jan Bednarsch, Emmanuel Boleslawski, Mohamed Rela, Anthony Wing-Hung Chan, Alejandro Forner, Maria Reig, Anais Pujals, Loetitia Favre, Manon Allaire, Olivier Scatton, Arnaud Uguen, Eric Trepo, Lukas Otero Sanchez, Denis Chatelain, Myriam Remmelink, Camille Boulagnon-Rombi, Celine Bazille, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Jakob Nikolas Kather, Annette S. H. Gouw, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Ruther, Soren A. Weidemann, Rami Rhaiem, Jean-Charles Nault, Alexis Laurent, Giuliana Amaddeo, Helene Regnault, Eleonora de Martin, Christine Sempoux, Pooja Navale, Jayendra Shinde, Ketan Bacchuwar, Maria Westerhoff, Regina Cheuk-Lam Lo, Mylene Sebbagh, Catherine Guettier, Marie Lequoy, Mina Komuta, Marianne Ziol, Valerie Paradis, Jeanne Shen, Stefano Caruso
Summary: Nestin protein is a valuable biomarker for diagnosis and prognosis assessment in cHCC-CCA. It can distinguish cHCC-CCA from HCC and has high prognostic value. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy.
JOURNAL OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Youyin Tang, Lingyan Wang, Fei Teng, Tao Zhang, Yunuo Zhao, Zheyu Chen
Summary: cHCC-CC patients had intermediate prognosis between HCC and ICC, with lymph node infiltration and postoperative TACE being independent risk factors associated with prognosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Wang, Gui-Qi Zhu, Chang-Wu Zhou, Na Li, Chun Yang, Meng-Su Zeng
Summary: This study aimed to investigate the role of clinicopathological factors and MR imaging factors in risk stratification of combined hepatocellular cholangiocarcinoma (cHCC-CCA) patients. The study found that different prognostic factors had varying effects on the recurrence of low-risk and high-risk patients, and based on these factors, patients could be stratified into different risk groups.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Yi Wang, Li Ma, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to investigate the correlation between MRI features and biomarkers, as well as prognostic factors for RFS and OS in cHCC-CCA patients. Results showed that cHCC-CCA imaging features were not correlated with AFP or CA19-9 levels. Age, CA19-9 > 37 U/ml, arterial phase peritumoral enhancement, and delayed enhancement were identified as independent predictors of poor RFS. Arterial phase peripheral enhancement was found to be an independent predictor of poor OS.
EUROPEAN RADIOLOGY
(2022)
Article
Cell Biology
Diane Dayoung Park, Gege Xu, Simon S. Park, Nathan E. Haigh, Chatchai Phoomak, Sopit Wongkham, Emanual Maverakis, Carlito B. Lebrilla
Summary: Research has found that secreted proteins in cholangiocarcinoma (CCA) cells are mainly fucosylated and fucosialylated glycoforms. By analyzing the glycan and protein profiles, it was discovered that combining the genes encoding fucosyltransferases and sialyltransferases with secretory protein-coding gene expression, particularly thrombospondin-1, had favorable prognostic effects and could provide improved risk assessment and indicate stages of disease progression in CCA patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Yu-Wen Zhou, Qing-Fang Li, Yue-Yun Chen, Kai Wang, Dan Pu, Xiao-Rong Chen, Chun-Hong Li, Li Jiang, Yan Wang, Qiu Li, Yu Yang, Hong-Feng Gou, Feng Bi, Ji-Yan Liu, Ye Chen, Meng Qiu
Summary: The study aimed to comprehensively understand combined hepatocellular and cholangiocarcinoma (CHC) and develop a prognostic nomogram. Data from the SEER database were analyzed, and propensity-score matching was used to compare CHC with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). A nomogram model was established to predict cancer-specific survival (CSS), and its performance was validated using a multicenter cohort. Results showed that CHC had better survival than HCC but was comparable to ICC. The novel nomogram, based on tumor size, M stage, chemotherapy, surgery, and radiotherapy, exhibited good discrimination power and clinical potential.
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Xin Lu, Yi Wang, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to distinguish MR features based on different proportions of the HCC component and investigate whether the proportion of HCC component could predict the prognosis of cHCC-CCA patients. The results showed that cHCC-CCAs with an HCC component >70% had a better overall survival prognosis compared to those with an HCC component <=70%.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolo Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri
Summary: Cholangiocarcinoma and combined hepatocellular cholangiocarcinoma are aggressive primary malignancies with liver resection as the main treatment modality. Locoregional therapies can provide local tumor control and increase chances of survival.
Article
Oncology
Xiaoyuan Chen, Yiwei Lu, Xiaoli Shi, Xuejiao Chen, Dawei Rong, Guoyong Han, Long Zhang, Chuangye Ni, Jie Zhao, Yun Gao, Xuehao Wang
Summary: This study found that the incidence of CHC remained stable between 2004 and 2018, with CHC displaying intermediate clinicopathological features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. By establishing a competing risk nomogram, it was discovered that race, tumor size, vascular invasion, extrahepatic invasion, distant metastasis, grade, surgery, and Metavir stage were independent predictors of cancer-specific survival.
JOURNAL OF ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jongjin Yoon, Jeong A. Hwang, Sunyoung Lee, Ji E. Lee, Sang Y. Ha, Young N. Park
Summary: The study compared clinicopathologic and imaging characteristics of cHCC-CCAs in high-risk patients with or without cirrhosis. Tumor size and LI-RADS categories differed significantly between the two groups, with LR-M category being a worse prognosis predictor.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Jitao Wang, Zhi Li, Yong Liao, Jinlong Li, Hui Dong, Hao Peng, Wenjing Xu, Zhe Fan, Fengxiao Gao, Chengyu Liu, Dengxiang Liu, Yewei Zhang
Summary: Combined hepatocellular carcinoma and cholangiocarcinoma (CHC) is a rare subtype of primary liver cancer. This study identified pathological grade, TNM stage, and surgery as independent prognostic factors for patients with CHC and developed a nomogram-based model to predict their overall survival.
FRONTIERS IN ONCOLOGY
(2021)