Review
Oncology
Rita Saude-Conde, Gertjan Rasschaert, Giacomo Bregni, Alain Hendlisz, Francesco Sclafani
Summary: This article summarises the current knowledge about HER2 alterations in CRC and the potential of anti-HER2 therapies. Recent studies confirm the therapeutic potential of established and new anti-HER2 agents, as well as the utility of liquid biopsy and ctDNA analyses for HER2 detection. HER2 represents a valuable target for emerging anti-HER2 therapies.
CURRENT OPINION IN ONCOLOGY
(2022)
Review
Oncology
Tresa M. McGranahan, Alipi Bonm, Jennifer M. Specht, Vyshak Venur, Simon S. Lo
Summary: This paper reviews the treatment options for patients with HER2+ breast cancer brain metastasis and provides a simplified algorithm for when to consider delaying local treatments.
Article
Pharmacology & Pharmacy
H. Qian, Wenzhi Huang, Y. Zhang, Xiaofei Cheng, C. Zhong, F. Tian, Ziang Chu, T. Zhou
Summary: This study aimed to investigate the association of epidermal growth factor receptor and human epidermal growth factor receptor 2 with colorectal cancer prognosis under FOLFOX chemotherapy. The results indicated that the upregulation of serum epidermal growth factor receptor and human epidermal growth factor receptor 2 may be a risk factor for poor prognosis of colorectal cancer.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pathology
Claud M. Grigg, Chad Livasy, Jiaxian He, Aaron Hartman, Peter E. Clark, Jason Zhu, Derek Raghavan, Earle F. Burgess
Summary: The study evaluated the concordance of HER2 expression in primary urothelial carcinomas and distant metastatic lesions, finding low agreement of HER2-positive status between the two, with loss of HER2 overexpression in some cases. The presence of HER2 ITH impacted the concordance, potentially influencing patient selection for HER2 targeted therapies.
Review
Oncology
Laura A. Huppert, Ozge Gumusay, Dame Idossa, Hope S. Rugo
Summary: HR-positive/HER2-negative breast cancer is characterized by the presence of estrogen receptor and/or progesterone receptor and the absence of HER2 gene amplification. It accounts for a significant proportion of breast cancers and is treated with endocrine therapy. Combining endocrine therapy with cyclin-dependent kinase inhibitors has shown promising results in reducing recurrence and improving survival. Chemotherapy is used based on the stage and tumor biology. New therapies, such as novel endocrine agents and antibody-drug conjugates, are changing the treatment landscape.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Chi-Son Chang, Jung In Shim, Sun-Ju Byeon, Eun Jin Lee, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Chel Hun Choi
Summary: This study investigated the prognostic significance of HER3 expression in cervical cancer. Immunohistochemistry analysis revealed that HER3 protein expression was associated with poor survival in cervical cancer patients and could serve as an independent prognostic factor. This finding could provide insights for individualized management of cervical cancer patients.
Review
Oncology
Anastasia Alataki, Mitch Dowsett
Summary: Endocrine therapies are the main treatment for hormone-dependent breast cancer, but HER2 signaling contributes to resistance and affects treatment efficacy. HER2 overexpression plays a role in resistance to endocrine therapies in breast cancer patients, impacting their clinical outcomes.
ENDOCRINE-RELATED CANCER
(2022)
Article
Pharmacology & Pharmacy
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Summary: This study investigated the expression of phosphorylated Focal adhesion kinase (p-FAK) in colorectal cancer (CRC) and its association with prognosis. The results showed that high p-FAK expression was associated with poor prognosis and poor chemotherapeutic response in CRC. Therefore, the expression level of p-FAK can serve as an independent prognostic biomarker for CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jinhua Ding, Li Jiang, Zheng Xu, Yong Chen, Weizhu Wu, Jian Huang
Summary: This study investigated the prognostic value of the 8th edition AJCC prognostic staging system in Chinese patients with luminal B-like HER2-negative breast cancer. The results showed that the prognostic staging system could better evaluate the survival rates of breast cancer and contribute to personalized treatment approaches.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Elena Daveri, Ana M. Adamo, Eugenia Alfine, Wei Zhu, Patricia Oteiza
Summary: The study found that hexameric PAC can inhibit proliferation and promote apoptosis of colorectal cancer cells by reducing the activity of the EGFR signaling pathway. It affects EGFR localization, promotes EGFR internalization, and synergizes with EGFR-targeted drugs, demonstrating anti-CRC effects.
Article
Oncology
Jae Yeon Jang, Young Kyung Jeon, Sun Young Jeong, Sung Hee Lim, Young Suk Park, Ho Yeong Lim, Jee Yun Lee, Seung Tae Kim
Summary: This study evaluated the impact of HER2 overexpression on outcomes of standard chemotherapy in patients with metastatic colorectal cancer (mCRC). The results showed that HER2 expression did not affect tumor response and survival in mCRC patients after standard chemotherapy.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jin-Jin Zhang, Chang-Xiong Cao, Li-Lan Wan, Wen Zhang, Zhong-Jiang Liu, Jin-Li Wang, Qiang Guo, Hui Tang
Summary: The aim of this study was to investigate the mechanism by which FOXQ1 promotes the invasion and metastasis of CRC through the HB-EGF/EGFR pathway. The results showed that knockdown of FOXQ1 suppressed the expression of HB-EGF, leading to a decrease in the expression levels of EGFR and its downstream genes AKT, RAF, and KRAS. This study suggests that FOXQ1 promotes CRC invasion and metastasis via the HB-EGF/EGFR pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Analytical
Minghao Qiu, Yuqing Ren, Lumin Huang, Xueying Zhu, Tikai Liang, Meijin Li, Dianping Tang
Summary: A sensitive electrochemical immunoassay platform for quantitatively monitoring human epidermal growth factor receptor 2 (HER2) is developed using iron nitrogen-doped carbon (FeNC) nanozyme-modified screen-printed carbon electrode and chronoamperometry. The system demonstrates good amperometric response and can detect target HER2 as low as 4.5 pg/mL. FeNC nanozyme-based sensing strategy offers high specificity and long-term stability, providing a new opportunity for protein diagnostics.
Article
Oncology
Shujuan Ni, Xin Wang, Jinjia Chang, Hui Sun, Weiwei Weng, Xu Wang, Cong Tan, Meng Zhang, Lei Wang, Zhaohui Huang, Dan Huang, Midie Xu, Weiqi Sheng
Summary: This study evaluated the HER2 status in a large cohort of Chinese colorectal cancer patients and found a positive correlation between HER2 expression and female gender. However, there was no significant correlation between HER2 status and patient survival according to any evaluation criterion used. Furthermore, HER2 protein expression was significantly negatively correlated with RAS/BRAF mutations according to the HERACLES criteria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ivica Ratosa, Nika Dobnikar, Michele Bottosso, Maria Vittoria Dieci, William Jacot, Stephane Pouderoux, Domen Ribnikar, Lea Sinoquet, Valentina Guarneri, Tanja Znidaric, Amelie Darlix, Gaia Griguolo
Summary: Leptomeningeal metastases (LM) in patients with HER2+ breast cancer are rare but often fatal. This multicentric study retrospectively gathered data from 82 patients with advanced HER2+ breast cancer and LM. The study found that absence of neurological symptoms and receiving radiotherapy were associated with prolonged overall survival.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Food Science & Technology
Mahsa Khanyaghma, Saman Milanizadeh, Pargol Ghavam Mostafavi, Seyed Reza Mohebbi, Tooraj Valinassab, Pedram Azimzadeh, Sara Romani, Mohammad Reza Zali
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2016)
Article
Public, Environmental & Occupational Health
Z. Hasani, H. Asadzadeh Aghdaei, H. Balaii, M. Azimirad, E. S. Mirsamadi, H. Mirjalali, M. R. Zali
EPIDEMIOLOGY AND INFECTION
(2017)
Article
Gastroenterology & Hepatology
Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari, Mohammad Mehdi Feizabadi
Article
Infectious Diseases
Masoumeh Azimirad, Anahita Dezfulian, Masoud Alebouyeh, Rasoul Bahreiny Esfehani, Shabnam Shahrokh, Mohammad Reza Zali
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2017)
Editorial Material
Medicine, General & Internal
Mohamad Amin Pourhoseingholi, Sara Ashtari, Nastaran Hajizadeh, Mohammad Reza Zali
Article
Oncology
Nastaran Hajizadeh, Mohamad Amin Pourhoseingholi, Ahmad Reza Baghestani, Alireza Abadi, Mohammad Reza Zali
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2017)
Article
Pathology
Leili Shokoohizadeh, Ashraf Mohabati Mobarez, Masoud Alebouyeh, Mohammad Reza Zali, Reza Ranjbar
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2017)
Article
Pediatrics
Leila Ganji, Masoumeh Azimirad, Nastaran Farzi, Masoud Alebouyeh, Mohammad Hassan Shirazi, Seyed Saeed Eshraghi, Abbas Mirshafiey, Naser Ebrahimi Daryani, Mohammad Reza Zali
ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
(2017)
Article
Microbiology
Masoumeh Azimirad, Marcela Krutova, Otakar Nyc, Zahra Hasani, Leili Afrisham, Masoud Alebouyeh, Mohammad Reza Zali
Article
Gastroenterology & Hepatology
Nastaran Hajizadeh, Ahmad Reza Baghestani, Mohamad Amin Pourhoseingholi, Sara Ashtari, Zeinab Fazeli, Mohsen Vahedi, Mohammad Reza Zali
WORLD JOURNAL OF HEPATOLOGY
(2017)
Article
Genetics & Heredity
Touraj Mahmoudi, Hossein Nobakht, Reza Dabiri, Iradj Maleki, Pooneh Dehghan, Fariborz Mansour-Ghanaei, Faramarz Derakhshan, Mohammad Reza Zali
Article
Infectious Diseases
Maryam Karkhane, Mohamad Amin Pourhoseingholi, Zahra Kimiia, Seyed Mehdi Mortazavi, Mohammad Reza Akbariyan Torkabad, Seyed Karim Hossieni Aghdam, Abdolrazagh Marzban, Mohammad Reza Zali
ARCHIVES OF CLINICAL INFECTIOUS DISEASES
(2016)
Article
Pharmacology & Pharmacy
Maryam Karkhane, Mohamad Amin Pourhosiengholi, Mohammad Reza Akbariyan Torkabad, Zahra Kimiia, Seyed Mehdi Mortazavi, Seyed Karim Hossieni Aghdam, Abdolrazagh Marzban, Mohammad Reza Zali
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2016)
Article
Biotechnology & Applied Microbiology
Touraj Mahmoudi, Keivan A. Majidzadeh, Khatoon Karimi, Hamid Farahani, Reza Dabiri, Hossein Nobakht, Asadollah Asadi, Negar Karimi, Maral Arkani, Mohammad Reza Zali
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2016)
Article
Medicine, General & Internal
Masoud M. Malekzadeh, Homayoon Vahedi, Kimiya Gohari, Parinaz Mehdipour, Sadaf G. Sepanlou, Nasser Ebrahimi Daryani, Mohammad Reza Zali, Fariborz Mansour-Ghanaei, Alireza Safaripour, Rahim Aghazadeh, Hassan Vossoughinia, Hafez Fakheri, Mohammad H. Somi, Iradj Maleki, Vahid Hoseini, Mohammad Reza Ghadir, Hamed Daghaghzadeh, Payman Adibi, Hamid Tavakoli, Alireza Taghavi, Mohammad Javad Zahedi, Taghi Amiriani, Masoud Tabib, Zainab Alipour, Hossein Nobakht, Abbas Yazdanbod, Masoud Sadreddini, Alireza Bakhshipour, Ahmad Khosravi, Pejman Khosravi, Siavosh Nasseri-Moghaddam, Shahin Merat, Rasoul Sotoudehmanesh, Farhad Barazandeh, Peyman Arab, Nadieh Baniasadi, Seyyed Javad Pournaghi, Mahboubeh Parsaeian, Farshad Farzadfar, Reza Malekzadeh
ARCHIVES OF IRANIAN MEDICINE
(2016)