Article
Endocrinology & Metabolism
Thiberiu Banica, Charlotte Verroken, Tim Reyns, Ahmed Mahmoud, Guy T'Sjoen, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
Summary: This study indicates that serum androgen levels start declining early in adult life, independently from changes in BMI and other lifestyle factors. The decline in androgen levels most likely arises from a primary decrease in testicular function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fang Huang, Yongchao Li, Yu Cui, Zewu Zhu, Jinbo Chen, Feng Zeng, Yang Li, Zhiyong Chen, Hequn Chen
Summary: The study aimed to evaluate the relationship between serum testosterone levels and kidney stone prevalence in males. The results showed a significant inverse association between serum testosterone levels and the prevalence of kidney stones in men over 40 years of age, but no correlation was seen in the 20-40 age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Andrology
Sky Graybill, Jennifer Hatfield, Maria Kravchenko, Darrick Beckman, Joshua Tate, Alexis Beauvais, Philip Clerc, Desarae Davila, Whitney Forbes, Jana Wardian, Matthew Kemm, Abegail Hubberd, Mark True
Summary: This study found that GLP-1 RA therapy improved weight and HbA1c without adverse effects on testosterone levels. Patients with lower baseline testosterone values or greater improvements in HbA1c may see additional benefits.
Article
Urology & Nephrology
Jun Ho Lee, Sung Won Lee
Summary: The study found that serum testosterone levels in middle-aged men vary monthly, with a nadir in May (4.4 ng/ml) and a peak in January (6.0 ng/ml). After adjusting for confounders, this monthly variation still exists, with testosterone levels showing a negative relationship with daylight duration and outdoor temperature.
JOURNAL OF UROLOGY
(2021)
Article
Biology
K. Barbara Sahlin, Indira Pla, Jessica de Siqueira Guedes, Krzysztof Pawlowski, Roger Appelqvist, Gyorgy Marko-Varga, Gilberto Barbosa Domont, Fabio Cesar Sousa Nogueira, Aleksander Giwercman, Aniel Sanchez, Johan Malm
Summary: Long term testosterone deficiency has negative effects on metabolism, muscle degradation, and metabolic diseases, while short-term testosterone changes seem to impact amino acid levels, with an association between tyrosine and phenylalanine levels and testosterone changes. The study suggests that fasting amino acid levels can be used to monitor early metabolic changes induced by testosterone fluctuations.
Review
Andrology
Alexander W. Pastuszak, Marc Gittelman, James P. Tursi, Jonathan S. Jaffe, David Schofield, Martin M. Miner
Summary: Endogenous diurnal testosterone variation decreases naturally with age. Men with testosterone deficiency lack diurnal testosterone variation and exhibit a flatter testosterone profile compared to men with normal testosterone levels. Some testosterone replacement options provide intraday testosterone level variations similar to normal circadian secretion, while others provide a flatter exposure profile reflective of depot release, and some exceed the frequency and physiological range of natural diurnal testosterone variation.
Article
Urology & Nephrology
Soum D. Lokeshwar, Premal Patel, Richard J. Fantus, Joshua Halpern, Cecilia Chang, Atil Y. Kargi, Ranjith Ramasamy
Summary: A study found that total testosterone (TT) levels have been declining among adolescent and young adult males over the past two decades. Higher body mass index (BMI) was associated with lower TT levels, a trend that remained significant even among men with normal BMI. Further studies are needed to verify these findings.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Endocrinology & Metabolism
J. A. Cauley, S. S. Ellenberg, A. V. Schwartz, K. E. Ensrud, T. M. Keaveny, P. J. Snyder
Summary: The study found that TBS is not clinically useful in monitoring the 1-year effect of testosterone treatment on bone structure in older hypogonadal men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Urology & Nephrology
Kajal Khodamoradi, Alexandra Dullea, Katherine Campbell, Christian Ramsoomair, Roei Golan, Ranjith Ramasamy
Summary: This study aimed to measure androgen receptor (AR) signaling levels in corpus cavernosal tissue of males with different serum testosterone (T) levels. The results showed no significant difference in VEGF expression above a serum T level of 200 ng/dl. Therefore, there may be a saturation level of approximately 200 ng/dl that fully saturates tissue androgen receptors and results in optimal male function.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Andrology
Robert Bozick
Summary: This study examines the relationship between men's testosterone levels and their sexual behaviors, finding that this relationship is contingent upon age, with positive correlation among younger men and negative correlation among older men.
Review
Gastroenterology & Hepatology
Nanfu Deng, Niharika Mallepally, Frederick B. Peng, Aleem Kanji, Marco Marcelli, Ruben Hernaez
Summary: Low serum testosterone is associated with increased morbidity and mortality in cirrhosis patients. Testosterone supplementation improved intermediate endpoints, but there was no conclusive data on clinical outcomes.
LIVER INTERNATIONAL
(2021)
Article
Andrology
Inari M. Ciccone, Elaine M. F. Costa, Juliana R. Pariz, Thiago A. Teixeira, Joel R. Drevet, Parviz Gharagozloo, Robert J. Aitken, Jorge Hallak
Summary: This cross-sectional study of 508 male patients found a positive correlation between serum vitamin D levels and semen quality, testosterone levels, and male reproductive potential. Specifically, higher levels of vitamin D3 were associated with better sperm concentration, motility, and morphology, as well as increased total testosterone levels.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Endocrinology & Metabolism
Taiba Zornitzki, Sagi Tshori, Galit Shefer, Shira Mingelgrin, Carmit Levy, Hilla Knobler
Summary: This study aimed to evaluate the association between the month of blood test performance and testosterone levels in a large cohort of males. The results showed that both total and bioavailable testosterone levels gradually decreased with age and BMI, and were lower in certain months. Factors such as diabetes and smoking were also found to affect testosterone levels. These findings provide strong evidence that seasonal variation needs to be considered in clinical practice.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Bu B. Yeap, Ali Ghasem-Zadeh, Kristy P. Robledo, David Jesudason, Jeffrey D. Zajac, Gary A. Wittert, Mathis Grossmann
Summary: In men aged 50 and above, testosterone treatment for 2 years increased volumetric bone density, primarily through effects on cortical bone. The effects on trabecular bone architecture were minor.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Paige L. Williams, Lidia Minguez-Alarcon, Susan A. Korrick, Mary M. Lee, Bora Plaku-Alakbarova, Jane S. Burns, Luidmila Smigulina, Yury Dikov, Ramy Abou Ghayda, Russ Hauser, Oleg Sergeyev
Summary: This study aimed to investigate the association between peripubertal blood lead levels (BLLs) and semen parameters and serum reproductive hormones among young Russian men. The findings suggest a possible link between higher peripubertal BLLs and lower ejaculate volume, but no associations were found between BLLs and reproductive hormones or other sperm parameters. Further research is warranted to explore this potential link and confirm the lack of associations among youth exposed to environmental BLLs.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Maliheh Nekouei Marvi Langari, Jaana Lindstrom, Pilvikki Absetz, Tiina Laatikainen, Jussi Pihlajamaki, Tanja Tilles-Tirkkonen, Hannele Turunen
Summary: This qualitative study explored the perspectives of Asian and Russian immigrants in Finland on healthy lifestyle and counseling. The study found that immigrants have limited knowledge on healthy lifestyle dimensions and that culture and community have an impact on healthy living. Additionally, the study identified shortcomings in health care for providing healthy lifestyle counseling and highlighted the influential individual factors for using counseling. Overall, the study emphasized the importance of developing a culturally tailored healthy lifestyle counseling program for immigrants to prevent chronic diseases.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Public, Environmental & Occupational Health
Hanna Tolonen, Jaakko Reinikainen, Zhi Zhou, Tommi Harkanen, Satu Mannisto, Pekka Jousilahti, Laura Paalanen, Annamari Lundqvist, Tiina Laatikainen
Summary: Non-communicable diseases share common modifiable risk factors and have both positive and unfavorable developments in Finland. While smoking, hypertension, and elevated total cholesterol are decreasing, obesity and diabetes are projected to increase. Regular monitoring and national goals are needed to tackle these issues.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Andrology
Laura Smidt Hansen, Laerke Priskorn, Stine A. Holmboe, Tina Kold Jensen, Ann Holm Hansen, Anna-Maria Andersson, Niels Jorgensen
Summary: This study found an association between testicular function and markers of metabolic and cardiovascular health in young men. Reproductive hormone levels and semen quality may serve as early biomarkers of cardiovascular health in healthy men.
Article
Public, Environmental & Occupational Health
Piia Lavikainen, Gunjan Chandra, Pekka Siirtola, Satu Tamminen, Anusha T. Ihalapathirana, Juha Roning, Tiina Laatikainen, Janne Martikainen
Summary: The purpose of this study was to identify patients with homogenous long-term HbA1c trajectories and predict trajectory membership using explainable machine learning methods and various predictors. The results showed that previous glucose levels, duration of type 2 diabetes, and use of antidiabetic medications were important predictors for long-term glycemic control.
CLINICAL EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, General & Internal
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study investigated the role of circulating AMH in men and found that low serum AMH is associated with severely impaired gonadal function. Vitamin D supplementation had no effect on serum AMH.
Article
Public, Environmental & Occupational Health
Matilde Laerkeholm Mueller, Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N. Upners, Margit B. Fischer, Casper P. Hagen, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Anna-Maria Andersson
Summary: The concentrations of potentially endocrine disrupting chemicals (EDCs) in the urine of infant boys were found to be associated with their serum reproductive hormone concentrations, suggesting that minipuberty is a critical developmental period highly sensitive to endocrine disruption.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Elvira V. Brauner, Cecilie S. Uldbjerg, Astrid L. Beck, Youn-Hee Lim, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Tina K. Jensen
Summary: This study investigated the relationship between maternal paraben concentrations in second trimester urine and birth size of the offspring, specifically looking at sex-specific associations. The findings revealed that higher maternal exposure to n-butylparaben was associated with lower birth size in female offspring, while no significant relationship was observed in male offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Endocrinology & Metabolism
Tuula Martiskainen, Marja-Leena Lamidi, Mika Venojaervi, Heikki Tikkanen, Tiina Laatikainen
Summary: This study evaluated the effectiveness of physical activity counseling in primary health care patients with Type 2 diabetes. The results showed that participants who attended counseling sessions more than three times had a significantly higher increase in physical activity. The study emphasizes the importance of an adequate amount and frequency of counseling sessions in lifestyle interventions.
BMC ENDOCRINE DISORDERS
(2023)
Article
Medicine, General & Internal
Onni Niemela, Aini Bloigu, Risto Bloigu, Mauri Aalto, Tiina Laatikainen
Summary: Recent studies have shown that ALT and GGT enzymes can be used as predictive biomarkers for both liver dysfunction and extrahepatic morbidity. Lifestyle factors such as alcohol use, smoking, adiposity, physical inactivity, and coffee consumption significantly influence the activities of ALT and GGT. Close links have been found between hepatic and extrahepatic morbidities, lifestyle risk factors, and liver enzyme abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Allergy
Tari Haahtela, Harri Alenius, Petri Auvinen, Nanna Fyhrquist, Leena von Hertzen, Pekka Jousilahti, Piia Karisola, Tiina Laatikainen, Jenni Lehtimaki, Laura Paalanen, Lasse Ruokolainen, Kimmo Saarinen, Erkka Valovirta, Tuula Vasankari, Tiina Vlasoff, Marina Erhola, Jean Bousquet, Erkki Vartiainen, Mika J. J. Makela
Summary: Contact with natural environments enriches the human microbiome, promotes immune balance, and protects against allergies and inflammatory disorders. The Karelia Allergy Study 2002-2022 showed that allergic conditions were more common on the Finnish side due to environmental and lifestyle changes. The Finnish Allergy Programme 2008-2018 and Nature Step to Health 2022-2032 have implemented measures to improve immune tolerance, nature contacts, and allergy health.
FRONTIERS IN ALLERGY
(2023)
Article
Endocrinology & Metabolism
Jyrki Mustonen, Paeivi Rautiainen, Marja-Leena Lamidi, Piia Lavikainen, Janne Martikainen, Tiina Laatikainen
Summary: A study of 642 adult type 1 diabetes patients using intermittently scanned continuous glucose monitoring (isCGM) found that isCGM can reduce the incidence of hypoglycemia and diabetic ketoacidosis. The study also found that isCGM can improve HbA1c levels.
ACTA DIABETOLOGICA
(2023)
Article
Public, Environmental & Occupational Health
Heini Wennman, Katja Borodulin, Pekka Jousilahti, Tiina Laatikainen, Tomi Maeki-Opas, Satu Maennistoe, Hanna Tolonen, Heli Valkeinen, Tommi Harkanen
Summary: Population-based projections in Finland indicate an increase in sitting time and a decrease in occupational physical activity among middle-aged and older adults. Leisure time appears to be a potential means to increase physical activity.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
