Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Felicia Visconti, Laura Rossi, Federico Donfrancesco, Cara M. Fleseriu, Federica Mirra, Alfredo Pontecorvi, Andrea Giustina, Maria Fleseriu, Laura De Marinis, Antonio Bianchi
Summary: Glucose metabolism in patients treated with PAS-LAR is often worsened, and may be predicted by the baseline GH hypersecretion and the dose of PAS-LAR. Limited data suggests that combination treatment with PAS-LAR + Peg-V may improve glucose homeostasis in selected patients.
Article
Endocrinology & Metabolism
Shin Urai, Masaaki Yamamoto, Naoki Yamamoto, Masaki Suzuki, Hiroki Shichi, Keitaro Kanie, Yasunori Fujita, Hironori Bando, Hidenori Fukuoka, Michiko Takahashi, Genzo Iguchi, Yutaka Takahashi, Wataru Ogawa
Summary: This study aimed to explore newer parameters of the octreotide test for predicting the therapeutic effect of first-generation somatostatin receptor ligands (fg-SRLs). The results showed that the area GH suppression rate-time under the curve (AUC) and the time to nadir GH level may be more reliable parameters for predicting tumor shrinkage.
Review
Endocrinology & Metabolism
Monica R. Gadelha, Ana Carolina Gadelha, Leandro Kasuki
Summary: The treatment of acromegaly has advanced significantly in recent decades, but there are still patients who do not respond to current treatments, highlighting the need for improved treatment burden. Fortunately, there are new treatments in development that may enhance treatment efficacy and convenience.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Przemyslaw Witek, Marek Bolanowski, Katarzyna Szamotulska, Agnieszka Wojciechowska-Luzniak, Aleksandra Jawiarczyk-Przybylowska, Marcin Kaluzny
Summary: The study aimed to evaluate the glucose metabolism in acromegaly patients treated with pasireotide LAR, showing a decrease in GH levels but worsening of metabolic status with increased HbA1c levels, necessitating intensifying antihyperglycemic treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascalu, Tiberiu Tirca, Jaqueline Abdul-Razzak, Mihaela Jana Tuculina
Summary: Acromegaly-related sub/infertility is associated with suboptimal disease control, hyperprolactinemia, hypogonadotropic hypogonadism, and glucose profile anomalies. This review explores the impact of acromegaly on pregnancy outcomes and discusses management strategies. The level of disease control, family history of diabetes, and body mass index are important predictors of maternal complications. Pharmacotherapy has been shown to be safe and effective in improving pregnancy outcomes.
Article
Medicine, General & Internal
So Jeong Yoon, Okjoo Lee, Ji Hye Jung, Sang Hyun Shin, Jin Seok Heo, In Woong Han
Summary: This study evaluated the utility of selective prophylactic octreotide for preventing postoperative pancreatic fistula in high-risk patients. The results showed that octreotide did not have a protective effect against pancreatic fistula, and routine use is not recommended.
Review
Endocrinology & Metabolism
Giovanni Tulipano, Andrea Giustina
Summary: Autophagy is an important cellular process involved in degradation and recycling, regulated by various stimuli and having complex roles in tumor cells. Research on autophagy in the pituitary gland and pituitary tumors is still relatively limited, but gaining attention for its potential implications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Yuki Yoshioka, Takanobu Saheki, Natsuki Ban, Kurumi Urushihara, Jingya Lyu, Tao Dong, Ryou Ishikawa, Kyuichi Kadota, Reiji Haba, Naoko Inoshita, Koji Murao
Summary: In this case, a 21-year-old woman with recurrent Cushing's disease and acromegaly showed a significant response to treatment initiation with pasireotide-long-acting release (LAR), indicating the efficacy of pasireotide-LAR in controlling both conditions. It is rare for Cushing's disease to present with acromegaly, and pharmacotherapy for this combination has not been widely discussed.
Article
Multidisciplinary Sciences
Jie Zhao, Hong Fu, Jingjing Yu, Weiqi Hong, Xiaowen Tian, Jieyu Qi, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai, Wei Yan, Xiawei Wei, Zhenhua Shao
Summary: The study investigates the activation mechanism of somatostatin receptor 2 (SSTR2) by two drugs, octreotide and paltusotine, and reveals their subtype selectivity and signal bias properties. The findings may guide the development of therapeutic drugs against neuroendocrine tumors with specific pharmacological profiles.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Maria Fleseriu, Fabienne Langlois, Dawn Shao Ting Lim, Elena V. Varlamov, Shlomo Melmed
Summary: Acromegaly, caused by growth hormone-secreting pituitary adenomas, is usually benign but can be locally invasive and progressive. It leads to a wide range of comorbidities and the normalization of growth hormone and insulin-like growth factor 1 is the primary therapeutic goal. A multimodal approach with surgery, medical therapy, and radiation therapy is required for optimal outcomes.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Kevin C. J. Yuen, Susan L. Samson
Summary: Oral octreotide capsules (OOCs) are an effective treatment option for acromegaly, providing suppression of growth hormone and insulin-like growth factor 1 levels, maintaining disease control, and reducing symptoms. The safety profile of OOC therapy is comparable to injectable somatostatin receptor ligands (SRLs), and patients express a preference for oral administration.
ENDOCRINE PRACTICE
(2022)
Article
Multidisciplinary Sciences
Joan Gil, Montserrat Marques-Pamies, Miguel Sampedro, Susan M. Webb, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Cristina Carrato, Antonio Pico, Araceli Garcia-Martinez, Luciana Martel-Duguech, Teresa Sardon, Andreu Simo-Servat, Betina Biagetti, Carles Villabona, Rosa Camara, Carmen Fajardo-Montanana, Cristina Alvarez-Escola, Cristina Lamas, Clara V. Alvarez, Ignacio Bernabeu, Monica Marazuela, Mireia Jorda, Manel Puig-Domingo
Summary: This study aimed to predict the response of acromegaly patients to somatostatin receptor ligands (SRL) using mathematical modeling and clinical information. Accuracy of patient stratification was significantly improved when the cohort was fragmented based on relevant clinical characteristics. The proposed stratification method based on tumor characteristics, sex, age, and multiple biomarkers achieved accuracies ranging from 71% to 95%. The use of data mining offers a promising approach for personalized medicine in acromegaly.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Marta Ragonese, Gianluca Di Bella, Federica Spagnolo, Loredana Grasso, Angela Alibrandi, Guiseppe Giuffrida, Mariacarla Moleti, Francesco Ferrau, Salvatore Cannavo
Summary: High NT-pro-BNP levels are associated with an increased risk of fatal or non-fatal CV events in acromegaly patients; a cut-off value of 91.55 pg/mL can predict the occurrence of CV events according to ROC analysis; surgically treated patients have a lower CV risk.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Endocrinology & Metabolism
W. Vena, A. Pizzocaro, G. Maida, M. Amer, A. Voza, A. Di Pasquale, F. Reggiani, M. Ciccarelli, C. Fedeli, D. Santi, E. Lavezzi, A. G. Lania, G. Mazziotti
Summary: Hypogonadism is common in male patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Low testosterone (T) levels are associated with unfavorable outcomes of COVID-19, and further prospective studies are needed to evaluate the long-term outcomes of hypogonadism related to COVID-19 and the clinical impact of T replacement during and after acute illness.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Oncology
Gherardo Mazziotti, Walter Vena, Rebecca Pedersini, Sara Piccini, Emanuela Morenghi, Deborah Cosentini, Paolo Zucali, Rosalba Torrisi, Silvio Sporeni, Edda L. Simoncini, Roberto Maroldi, Luca Balzarini, Andrea G. Lania, Alfredo Berruti
Summary: This study investigated the reliability of the WHO Fracture Risk Assessment Tool (FRAX) and bone mineral density (BMD) in identifying vertebral fractures in cancer survivors undergoing hormone-deprivation therapies (HDTs). The results showed that FRAX and BMD may be useful for predicting vertebral fractures in patients undergoing HDTs.
JOURNAL OF BONE ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Carlotta Palumbo, Alberto Dalla Volta, Stefania Zamboni, Gherardo Mazziotti, Manuel Zamparini, Luca Triggiani, Paolo Borghetti, Filippo Maffezzoni, Roberto Bresciani, Luca Rinaudo, Francesca Valcamonico, Davide Farina, Stefano Maria Magrini, Alessandro Antonelli, Claudio Simeone, Alfredo Berruti
Summary: Degarelix administration is associated with a significant decrease in bone mineral density and increase in bone turnover markers. ALMI is a promising predictor of bone loss in prostate cancer patients receiving androgen deprivation therapy, and changes in ALMI during therapy are associated with bone turnover derangement favoring bone quality alterations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
S. Cannavo, M. Cappa, D. Ferone, A. M. Isidori, S. Loche, M. Salerno, M. Maghnie
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
E. Biamonte, R. Levi, F. Carrone, W. Vena, A. Brunetti, M. Battaglia, F. Garoli, G. Savini, M. Riva, A. Ortolina, M. Tomei, G. Angelotti, M. E. Laino, V. Savevski, M. Mollura, M. Fornari, R. Barbieri, A. G. Lania, M. Grimaldi, L. S. Politi, G. Mazziotti
Summary: This study evaluated radiomics features on CT images of the lumbar spine to identify associations with fragility vertebral fractures. The results showed that specific radiomics features were significantly associated with the presence of fractures, regardless of bone mineral density status.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Giulia Carosi, Alessandro Brunetti, Alessandra Mangone, Roberto Baldelli, Alberto Tresoldi, Giulia Del Sindaco, Elisabetta Lavezzi, Elisa Sala, Roberta Mungari, Letizia Maria Fatti, Elena Galazzi, Emanuele Ferrante, Rita Indirli, Emilia Biamonte, Maura Arosio, Renato Cozzi, Andrea Lania, Gherardo Mazziotti, Giovanna Mantovani
Summary: This study is the largest cohort of patients with primary empty sella (PES) reported to date. The results show that 40% of PES patients have hypopituitarism, but hormonal deterioration is relatively low (3%). This suggests that patients need to be carefully evaluated at diagnosis, even if PES is incidentally discovered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
W. Vena, F. Carrone, A. Delbarba, O. Akpojiyovbi, L. C. Pezzaioli, P. Facondo, C. Cappelli, L. Leonardi, L. Balzarini, D. Farina, A. Pizzocaro, A. G. Lania, G. Mazziotti, A. Ferlin
Summary: This study evaluated the associations between body composition parameters, vertebral fractures, and trabecular bone score in adult males with Klinefelter syndrome. The results suggest that body composition may influence bone quality and the risk of vertebral fractures in individuals with Klinefelter syndrome.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
M. F. Birtolo, W. Vena, A. Pizzocaro, E. Lavezzi, A. Brunetti, S. Jaafar, N. Betella, A. C. Bossi, G. Mazziotti, A. G. Lania
Summary: This study investigated the relationship between serum testosterone levels and outcomes of COVID-19 in a large cohort of female patients. The results showed that high testosterone levels were associated with higher inflammatory markers and worse course of COVID-19, although this association disappeared after correcting for inflammatory parameters.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
L. Cianferotti, C. Cipriani, S. Corbetta, G. Corona, G. Defeudis, A. G. Lania, C. Messina, N. Napoli, G. Mazziotti
Summary: Endocrine diseases can lead to osteoporosis and fractures, but traditional bone density measurement methods may not accurately capture skeletal alterations caused by endocrine disorders. Therefore, it is important to use new techniques to assess bone quality for the diagnosis and prediction of skeletal fragility and fracture risk.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante, Arturo Chiti
Summary: This study investigated the potential role of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) and found that PSMA expression and 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG) uptake on PET/CT can serve as complementary biomarkers for TC outcome prediction.
Review
Nutrition & Dietetics
Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Laura Croce, Marco Malaguti, Alfredo Campenni, Mario Rotondi, Salvatore Cannavo, Silvana Hrelia
Summary: Autoimmune thyroid diseases are increasing rapidly worldwide due to environmental factors related to changed lifestyles. Unhealthy high-energy diets negatively affect autoimmunity, while the Mediterranean diet positively influences immune system function, gut microbiota composition, and redox homeostasis.
Article
Health Care Sciences & Services
Agata Zirilli, Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Silvana Hrelia, Luca Giovanella, Alfredo Campenni, Salvatore Cannavo, Angela Alibrandi
Summary: This study aimed to assess the differences in oxidative stress markers between omnivorous and semi-vegetarian dietary regimes. The findings indicate that semi-vegetarians have higher levels of antioxidant parameters (GPx and TRxR) and lower levels of AGE and AOPP markers compared to omnivorous individuals, particularly in females, different age groups, those with normal weight, and those not affected by Hashimoto's thyroiditis.
Article
Endocrinology & Metabolism
Maria Francesca Birtolo, Simone Antonini, Andrea G. Lania, Gherardo Mazziotti
Summary: Skeletal fragility and vertebral fractures are common complications of growth hormone hypersecretion in acromegalic subjects. The coexistence of spine arthropathy further negatively impacts the quality of life for these patients. Managing these complications can be challenging even after controlling the disease biochemically. This article provides an analysis of the pathophysiological links between vertebral fractures and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects of managing acromegalic osteo-arthropathy.
Article
Endocrinology & Metabolism
Gherardo Mazziotti, Rebecca Pedersini, Walter Vena, Deborah Cosentini, Flaminia Carrone, Stella Pigni, Edda L. Simoncini, Rosalba Torrisi, Alberto Zambelli, Davide Farina, Luca Balzarini, Andrea G. Lania, Alfredo Berruti
Summary: This prospective study aimed to investigate the real-life effectiveness of bone-active drugs on the risk of vertebral fractures induced by aromatase inhibitors (AIs) in breast cancer patients. The results suggest that in real-world clinical practice, denosumab and zoledronate can significantly reduce the risk of vertebral fractures in breast cancer patients using AIs.
CALCIFIED TISSUE INTERNATIONAL
(2022)