D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly

Context: A discrepancy between serum GH and IGF1 concentrations is frequent ill patients with acromegaly Here. we examined whether the exon 3-deleted (d3) GH receptor (GHR) variant., which has been linked to increased responsiveness to GH treatment in short children, influences the GH/IGF1 relationship in patients with acromegaly. Objective: To study the possible influence of the GHR genotype oil the GH/IGF1 relationship in untreated acromegalic patients. Design: GHR genotype analysis with retrospective clinical and biochemical data collection performed ill it single third-reference medical center. Patients and methods: Clinical data were obtained from the medical records of 105 acromegalic patients who had GH and IGF1. assays in the same laboratory and who were genotyped For the Full-length (fl) or d3-GHR alleles. Results: The distribution of GHR genotypes was 51%, fl/fl, 30%, fl/d3. and 19% d3/d3. Patients with d3/d3 genotype were younger than the patients in the other two groups (P<0.05). Baseline GH and [GF]. concentrations did not differ among the three groups. The linear correlation between GH and IGF1 concentrations was similar in the three genotypic groups. Conclusions: The exon 3 GHR genotype does not affect, the GH/IGF1 relationship in untreated acromegalic patients with high circulating GH and IGF1 levels.