期刊
EUROPEAN JOURNAL OF ENDOCRINOLOGY
卷 160, 期 2, 页码 121-133出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/EJE-08-0756
关键词
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资金
- Helsinki University Central Hospital Research Fund
- Research Grant Council, Hong Kong [HKU 7514/05M, HKU 7647/06M]
Glycodelin is an endocrine-regulated glycoprotein that has significant effects on immune cells. apoptosis, reproduction, cell adhesion, differentiation and cancer. In reproduction, glycodelin contributes to capacitation and immunoprotection of spermatozoa, and it modulates sperm-oocyte binding, acrosome reaction and implantation. In endocrine-related cancer, the differentiation inducing effects of glycodelin are accompanied by growth restriction of malignant cells, decreased expression of oncogenes, increased expression of tumour suppressor genes and morphological reversion of the malignant phenotype. This review features these properties and clinical connections, highlighting the role of glycosylation in biological actions.
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