Review
Biochemistry & Molecular Biology
Sabine Weber, Alexander L. Gerbes
Summary: Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which poses a major challenge for diagnosis in clinical practice and pharmacovigilance. Efforts have been made to establish diagnostic testing methods and biomarkers for safe diagnosis and differentiation from other liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Xiaoyun Li, Jieting Tang, Yimin Mao
Summary: The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Antibiotics are the leading cause of DILI in Western countries, while traditional Chinese medicine is the primary cause in Eastern countries. The incidence of hepatotoxicity induced by herbal and dietary supplements is increasing globally. Although several risk factors for DILI have been described, there are no confirmed risk factors for all-cause DILI.
LIVER INTERNATIONAL
(2022)
Article
Toxicology
Guillermo Quintas, Teresa Martinez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans, Jose Castell
Summary: DILI, an adverse toxic reaction associated with drug administration, is currently classified based on ALT and ALP values, but lacks accuracy. By integrating metabolomic information, a more accurate evaluation of DILI phenotypes can be achieved.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Dina Halegoua-DeMarzio, Victor Navarro, Jawad Ahmad, Bharathi Avula, Huiman Barnhart, A. Sidney Barritt, Herbert L. Bonkovsky, Robert J. Fontana, Marwan S. Ghabril, Jay H. Hoofnagle, Ikhlas A. Khan, David E. Kleiner, Elizabeth Phillips, Andrew Stolz, Raj Vuppalanchi
Summary: This case series study describes the clinical, histological, and HLA associations of turmeric-associated liver injury cases in the US Drug-Induced Liver Injury Network (DILIN). Ten cases of turmeric-associated liver injury were found, predominantly in women and with a strong linkage to HLA-B*35:01. Chemical analysis confirmed the presence of turmeric in all tested products. The study suggests an increasing trend of liver injury due to turmeric in the United States.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mirjana Stanic Benic, Lana Nezic, Vesna Vujic-Aleksic, Liliana Mititelu-Tartau
Summary: Many drugs can cause hepatotoxicity, and the treatment of drug-induced liver injury (DILI) is challenging. This study searched various databases to summarize the mechanisms, potential benefits, and adverse reactions of novel therapies for managing DILI. The evidence suggests that MgIG treatment may be effective in normalizing ALT levels, while bicyclol treatment may reduce ALT levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Anna Licata, Maria Giovanna Minissale, Simona Stankeviciute, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J. Andrade, Piero Luigi Almasio
Summary: N-acetylcysteine (NAC) is an effective therapeutic option for acetaminophen (APAP) overdose, improving hepatotoxicity and reducing mortality. The timing of treatment initiation, within 8 to 24 hours after APAP overdose, is crucial for preventing or minimizing liver damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Camille Houron, Marie Danielou, Olivier Mir, Bernard Fromenty, Gabriel Perlemuter, Cosmin Sebastian Voican
Summary: Multikinase inhibitors (MKI) have revolutionized cancer management, but there is a lack of data on MKI-related liver injury risk and clinical guidelines. Liver toxicity from MKI typically occurs one to two months after treatment initiation, with hepatocellular toxicity being more common. Early detection and monitoring of liver function are crucial for managing MKI-induced liver injury.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Vicenc Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
Summary: Chemotherapy-induced hepatotoxicity is a significant concern in cancer treatment, but curcumin has emerged as a potential strategy to mitigate this adverse effect. By targeting specific molecular mechanisms, curcumin exhibits anti-inflammatory, antioxidant, antifibrotic, and hypolipidemic properties that can help prevent and reduce chemotherapy-induced liver injury. Further clinical investigation is needed to demonstrate the efficacy of bioavailable curcumin formulations as hepatoprotective agents in cancer patients.
Article
Pharmacology & Pharmacy
Marja Driessen, Suzanne van der Plas-Duivesteijn, Anne S. Kienhuis, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water, Herman P. Spaink, Magnus Palmblad, Leo T. M. van der Ven, Jeroen L. A. Pennings
Summary: The zebrafish embryo is a promising model for studying hepatotoxicity and could potentially reduce the use of rodents in such assessments. Proteomics analysis identified a set of potential protein markers for detecting adverse liver responses.
Article
Toxicology
Fernando Bessone, Antonella Ferrari, Nelia Hernandez, Manuel Mendizabal, Ezequiel Ridruejo, Alina Zerega, Federico Tanno, Maria Virginia Reggiardo, Julio Vorobioff, Hugo Tanno, Marco Arrese, Vinicius Nunes, Martin Tagle, Inmaculada Medina-Caliz, Mercedes Robles-Diaz, Hao Niu, Ismael Alvarez-Alvarez, Camilla Stephens, M. Isabel Lucena, Raul J. Andrade
Summary: In this study, the demographics, clinical characteristics, biochemical features, and outcome of nitrofurantoin-induced liver injury were described. The majority of the cases were women with a mean age of 61 years. Hepatocellular damage was the most common pattern of liver injury, and about half of the patients were asymptomatic. Most patients recovered within six months, but a small number developed nitrofurantoin-induced autoimmune-like hepatitis.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mercedes Robles-Diaz, Lana Nezic, Vesna Vujic-Aleksic, Einar S. Bjornsson
Summary: UDCA may have some benefits in the treatment and prevention of DILI according to available data, but a well designed RCT is needed to draw a firm conclusion on its efficacy in DILI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Spectroscopy
Zhao Wang, Fan Zhang, Jianhua Xiong, Zhiqiang Mao, Zhihong Liu
Summary: This study developed a two-photon fluorescence probe for peroxynitrite, which can sensitively image ONOO- in mouse liver and demonstrate the potential application in DILI screening.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yi-Shin Huang, Ting-Tsung Chang, Cheng-Yuan Peng, Gin-Ho Lo, Chao-Wei Hsu, Chi-Tan Hu, Yi-Hsiang Huang
Summary: The study found that herbal and dietary supplements accounted for more than one-fifth of drug-induced liver injuries in Taiwan, and patients with HILI were more severe and had a higher mortality rate compared to those with CILI. Hepatitis B carriers, individuals with elevated baseline liver tests, and users of crude herbs may face a higher risk of HILI-related mortality. Prudent use of HDS is recommended for these high-risk individuals.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Toxicology
Samantha Korver, Joanne Bowen, Kara Pearson, Raymond J. Gonzalez, Neil French, Kevin Park, Rosalind Jenkins, Christopher Goldring
Summary: DILI is a common adverse effect in drug therapy, with CK18 identified as a potential new biomarker for diagnosing early-stage DILI and providing insights into the mechanism of hepatocellular injury. However, further research is needed to characterize CK18 in preclinical models of DILI, particularly in vivo rat models.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Plant Sciences
Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose, Mohd. Kashif Kidwai
Summary: Drug-induced liver injury is a challenging problem for hepatologists, and the quantification of medication hepatotoxicity is difficult. This review compares pharmaceutical drugs and herbal compounds in terms of their metabolic mechanisms and hepatoprotective effects, highlighting the lower adverse effects of herbal substances. Understanding the metabolic mechanisms of drugs is crucial for mitigating hepatotoxicity, and pre-clinical pharmacological research shows promise for the development of natural products as therapeutic agents.
Article
Medicine, General & Internal
Antonios Douros, Frederike Basedow, Ying Cui, Jenny Dimakos, Jochen Walker, Dirk Enders, Vicky Tagalakis
Summary: Among octogenarians with venous thromboembolism, DOACs showed comparable effectiveness and safety compared to VKAs in preventing recurrent venous thromboembolism, major bleeding, and all-cause mortality. These results support the use of DOACs in this high-risk group.
AMERICAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Peripheral Vascular Disease
Sverre E. Kjeldsen, Brent M. Egan, Krzysztof Narkiewicz, Reinhold Kreutz, Michel Burnier, Suzanne Oparil, Giuseppe Mancia
Article
Endocrinology & Metabolism
Jenny Dimakos, Ying Cui, Robert W. Platt, Christel Renoux, Kristian B. Filion, Antonios Douros
Summary: This population-based cohort study explored the potential association between concurrent use of sulfonylureas and beta-blockers and the risk of severe hypoglycemia. The results showed that concomitant use of sulfonylureas and beta-blockers increased the risk of severe hypoglycemia compared to sulfonylurea use alone, and the cardioselectivity of beta-blockers did not seem to play a major role in this regard.
Article
Endocrinology & Metabolism
Nehal Islam, Pauline Reynier, Antonios Douros, Oriana H. Y. Yu, Kristian B. Filion
Summary: By analyzing data from the Clinical Practice Research Datalink Aurum, it was found that sulphonylurea monotherapy is associated with an increased risk of ventricular arrhythmia compared to metformin monotherapy when initiating pharmacotherapy for type 2 diabetes. Therefore, the increased risk should be taken into consideration when prescribing sulphonylureas as an initial treatment for type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Immunology
Antonios Douros, Zharmaine Ante, Samy Suissa, Paul Brassard
Summary: The findings of a large population-based cohort study suggest that common vaccines do not have a protective effect on the risk of dementia, contradicting previous observational data.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Tianze Jiao, Robert W. Platt, Antonios Douros, Kristian B. Filion
Summary: Statistical approaches to adaptive treatment strategies can be used to simulate sequential decision-making in clinical practice. In this study, a statistical ATS approach was used to emulate a target trial of different blood pressure control plans. The results show that ATS can be used to simulate randomized controlled trials of complex treatment strategies in an observational setting.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Editorial Material
Peripheral Vascular Disease
Michel Burnier, Jana Brguljan, Engi Abd Elhady Algharably, Sverre E. Kjeldsen, Krzysztof Narkiewicz, Brent Egan, Suzanne Oparil, Reinhold Kreutz
Review
Pharmacology & Pharmacy
Christopher A. Gravel, Antonios Douros
Summary: Pharmacovigilance studies rely on disproportionality analysis to identify drug-event combinations with higher reporting than expected. The enhanced reporting serves as a proxy for signals, generating drug safety hypotheses for further investigation. The choice of comparator in pharmacovigilance studies is currently uncertain, as is its impact on reporting and other biases. This review examines commonly used comparators and their advantages and disadvantages, highlighting the challenges in deriving general recommendations for comparator selection in mining spontaneous reports for pharmacovigilance.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Christopher A. Gravel, Daniel Krewski, Donald R. Mattison, Franco Momoli, Antonios Douros
Summary: This study aimed to assess the risk of myotoxicity associated with the concomitant use of SGLT2 inhibitors and statins. The results showed that there was no increased risk of myotoxicity when using SGLT2 inhibitors and statins together.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jenny Dimakos, Ying Cui, Robert W. Platt, Christel Renoux, Kristian B. Filion, Antonios Douros
Summary: This population-based study aimed to investigate the interaction between dipeptidyl peptidase-4 inhibitors (DPP-4i) and sulfonylureas in relation to the risk of hypoglycemia. The study found that the pharmacologic heterogeneity of sulfonylureas (long- vs. short-acting) and DPP-4i (peptidomimetic vs. non-peptidomimetic) did not modify this interaction. Therefore, these factors do not affect the risk of hypoglycemia.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
News Item
Peripheral Vascular Disease
Rosa de Pinho, Fabiolucio Albini, Janos Nemcsik, Michael Doumas, Reinhold Kreutz
Letter
Cardiac & Cardiovascular Systems
Antonios Douros, Alice Schneider, Natalie Ebert, Anne-Katrin Fietz, Dorte Huscher, Martin K. Kuhlmann, Peter Martus, Nina Mielke, Markus van der Giet, Volker Wenning, Elke Schaeffner
JACC-HEART FAILURE
(2023)
Meeting Abstract
Transplantation
Cedric Villain, Natalie Ebert, Tim Bothe, Muhammad Barghouth, Anne-Katrin Fietz, Antonios Douros, Nina Mielke, Elke Schaeffner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Physiology
Ramzi Khalil, Josephine D. D. Bonnemaijer, Reinhold Kreutz, Herman P. Spaink, Pancras C. W. Hogendoorn, Hans J. Baelde
Summary: Transmembrane protein 14A (TMEM14A) is an important protein involved in maintaining the integrity of the glomerular filtration barrier. It suppresses Bax-mediated apoptosis and its expression is increased in proteinuric renal diseases.
PHYSIOLOGICAL REPORTS
(2023)
Review
Endocrinology & Metabolism
Samuel Igweokpala, Naheemot Olaoluwa Sule, Antonios Douros, Oriana H. Y. Yu, Kristian B. Filion
Summary: The use of incretin-based drugs is not associated with the risk of diabetic retinopathy among individuals with type 2 diabetes, according to the synthesis of available evidence from observational studies.
DIABETES OBESITY & METABOLISM
(2023)